PMID- 25403892
OWN - NLM
STAT- MEDLINE
DCOM- 20150324
LR  - 20150113
IS  - 1521-4141 (Electronic)
IS  - 0014-2980 (Linking)
VI  - 45
IP  - 1
DP  - 2015 Jan
TI  - Dendritic cell specific targeting of MyD88 signalling pathways in vivo.
PG  - 32-9
LID - 10.1002/eji.201444747 [doi]
AB  - Dendritic cells (DCs) are key regulators of both innate and adaptive immunity. 
      During infection, DCs recognise pathogen-associated molecular patterns (PAMPs) 
      via pattern recognition receptors (PRRs) including the Toll-like receptor (TLR) 
      family. TLRs mainly signal via the adaptor protein MyD88. This signalling pathway 
      is required for immune protection during many infections, which are lethal in the 
      absence of MyD88. However, the cell type specific importance of this pathway 
      during both innate and adaptive immune responses against pathogens in vivo 
      remains ill-defined. We discuss recent findings from conditional KO or 
      gain-of-function mouse models targeting TLR/MyD88 signalling pathways in DCs and 
      other myeloid cells during infection. While the general assumption that 
      MyD88-dependent recognition by DCs is essential for inducing protective immunity 
      holds true in some instances, the results surprisingly indicate a much more 
      complex context-dependent requirement for this pathway in DCs and other myeloid 
      or lymphoid cell-types in vivo. Furthermore, we highlight the advantages of 
      Cre-mediated DC targeting approaches and their possible limitations. We also 
      present future perspectives on the development of new genetic mouse models to 
      target distinct DC subsets in vivo. Such models will serve to understand the 
      functional heterogeneity of DCs in vivo.
CI  - (c) 2014 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
FAU - Arnold-Schrauf, Catharina
AU  - Arnold-Schrauf C
AD  - Institute for Infection Immunology, TWINCORE, Center for Experimental and 
      Clinical Infection Research, a Joint Venture between the Medical School Hannover 
      (MHH) and the Helmholtz Center for Infection Research (HZI), Hannover, Germany.
FAU - Berod, Luciana
AU  - Berod L
FAU - Sparwasser, Tim
AU  - Sparwasser T
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20141216
PL  - Germany
TA  - Eur J Immunol
JT  - European journal of immunology
JID - 1273201
RN  - 0 (Myd88 protein, mouse)
RN  - 0 (Myeloid Differentiation Factor 88)
RN  - 0 (Toll-Like Receptors)
RN  - EC 2.7.7.- (Cre recombinase)
RN  - EC 2.7.7.- (Integrases)
SB  - IM
MH  - Adaptive Immunity
MH  - Animals
MH  - Candida albicans/immunology
MH  - Candidiasis/genetics/*immunology/microbiology
MH  - Dendritic Cells/*immunology/microbiology/parasitology
MH  - Gene Expression Regulation
MH  - Immunity, Innate
MH  - Integrases/genetics/metabolism
MH  - Mice
MH  - Mice, Transgenic
MH  - Myeloid Differentiation Factor 88/genetics/*immunology
MH  - Promoter Regions, Genetic
MH  - Signal Transduction/genetics/*immunology
MH  - Toll-Like Receptors/genetics/*immunology
MH  - Toxoplasma/immunology
MH  - Toxoplasmosis/genetics/*immunology/parasitology
OTO - NOTNLM
OT  - Cell type specific recombination
OT  - DC targeting
OT  - Infection
OT  - MyD88/TLR signalling
OT  - Transgenic mice
EDAT- 2014/11/19 06:00
MHDA- 2015/03/25 06:00
CRDT- 2014/11/19 06:00
PHST- 2014/08/18 00:00 [received]
PHST- 2014/11/09 00:00 [revised]
PHST- 2014/11/11 00:00 [accepted]
PHST- 2014/11/19 06:00 [entrez]
PHST- 2014/11/19 06:00 [pubmed]
PHST- 2015/03/25 06:00 [medline]
AID - 10.1002/eji.201444747 [doi]
PST - ppublish
SO  - Eur J Immunol. 2015 Jan;45(1):32-9. doi: 10.1002/eji.201444747. Epub 2014 Dec 16.