PMID- 25405235
OWN - NLM
STAT- MEDLINE
DCOM- 20151109
LR  - 20210130
IS  - 1537-744X (Electronic)
IS  - 2356-6140 (Print)
IS  - 1537-744X (Linking)
VI  - 2014
DP  - 2014
TI  - Association of interleukin-18 gene polymorphism with susceptibility to visceral 
      leishmaniasis in endemic area of Bihar, an Indian population.
PG  - 852104
LID - 10.1155/2014/852104 [doi]
LID - 852104
AB  - Interleukin-18 (IL-18) is a cytokine that mediates Th1 response by inducing 
      interferon-gamma (IFN-gamma) production in T cells and natural killer cells. Genetic 
      polymorphisms in the IL-18 gene have been found to be associated with its 
      expression in cancer, tuberculosis, HBV infection, and various other diseases. 
      Lower plasma level of IL-18 in visceral leishmaniasis (VL) patients might be 
      associated with polymorphisms in the regulating or coding region of the gene. 
      Three single nucleotide polymorphisms (SNPs), rs1946519 (-656 G/T) and rs187238 
      (-137 G/C) in the promoter region and rs549908 (+105 A/C) in the codon region, 
      were genotyped in 204 parasitological confirmed VL patients and 267 controls with 
      no past history of VL. For each locus, polymerase chain reaction (PCR) followed 
      by restriction digestion was performed. IL-18 expression in peripheral blood 
      mononuclear cells (PBMC) collected from VL patients and controls was measured by 
      quantitative real-time RT-PCR. Distribution of G allele at position -656 (P < 
      0.0001) and double haplotypes GGC/GGA (P = 0.05) were found to be significantly 
      associated with controls while genotypes TT (P < 0.0001) and single haplotypes 
      TGA (P = 0.0002), with cases. The inheritance of G allele at the position -656 
      might be considered as a protective allele for VL.
FAU - Kumar, Dinesh
AU  - Kumar D
AD  - Infectious Disease Research Laboratory, Department of Medicine, Institute of 
      Medical Sciences, Banaras Hindu University, Varanasi, Uttar Pradesh 221 005, 
      India.
FAU - Tiwary, Puja
AU  - Tiwary P
AD  - Infectious Disease Research Laboratory, Department of Medicine, Institute of 
      Medical Sciences, Banaras Hindu University, Varanasi, Uttar Pradesh 221 005, 
      India.
FAU - Chakravarty, Jaya
AU  - Chakravarty J
AD  - Infectious Disease Research Laboratory, Department of Medicine, Institute of 
      Medical Sciences, Banaras Hindu University, Varanasi, Uttar Pradesh 221 005, 
      India.
FAU - Sundar, Shyam
AU  - Sundar S
AUID- ORCID: 0000-0001-9988-582X
AD  - Infectious Disease Research Laboratory, Department of Medicine, Institute of 
      Medical Sciences, Banaras Hindu University, Varanasi, Uttar Pradesh 221 005, 
      India.
LA  - eng
GR  - P50 AI074321/AI/NIAID NIH HHS/United States
GR  - U19 AI074321/AI/NIAID NIH HHS/United States
GR  - 1P50AI074321/AI/NIAID NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20141022
PL  - United States
TA  - ScientificWorldJournal
JT  - TheScientificWorldJournal
JID - 101131163
RN  - 0 (Interleukin-18)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Alleles
MH  - Case-Control Studies
MH  - Child
MH  - *Endemic Diseases
MH  - Female
MH  - Gene Frequency
MH  - *Genetic Predisposition to Disease
MH  - Haplotypes
MH  - Humans
MH  - India/epidemiology
MH  - Interleukin-18/*genetics/immunology
MH  - Leishmania donovani/immunology
MH  - Leishmania infantum/immunology
MH  - Leishmaniasis, Visceral/*epidemiology/*genetics/immunology/parasitology
MH  - Leukocytes, Mononuclear/immunology/parasitology
MH  - Male
MH  - Open Reading Frames
MH  - *Polymorphism, Single Nucleotide
MH  - Promoter Regions, Genetic
PMC - PMC4227453
EDAT- 2014/11/19 06:00
MHDA- 2015/11/10 06:00
PMCR- 2014/10/22
CRDT- 2014/11/19 06:00
PHST- 2014/07/30 00:00 [received]
PHST- 2014/09/24 00:00 [revised]
PHST- 2014/09/25 00:00 [accepted]
PHST- 2014/11/19 06:00 [entrez]
PHST- 2014/11/19 06:00 [pubmed]
PHST- 2015/11/10 06:00 [medline]
PHST- 2014/10/22 00:00 [pmc-release]
AID - 10.1155/2014/852104 [doi]
PST - ppublish
SO  - ScientificWorldJournal. 2014;2014:852104. doi: 10.1155/2014/852104. Epub 2014 Oct 
      22.