PMID- 2540694
OWN - NLM
STAT- MEDLINE
DCOM- 19890531
LR  - 20161123
IS  - 0364-5134 (Print)
IS  - 0364-5134 (Linking)
VI  - 25
IP  - 4
DP  - 1989 Apr
TI  - Early cerebellar degeneration in twins with infantile neuroaxonal dystrophy.
PG  - 413-5
AB  - Dizygotic twin girls with typical infantile neuroaxonal dystrophy (INAD) were 
      studied at age 19 months with computed tomography and magnetic resonance imaging 
      (MRI). Both methods showed distinct atrophy confined to the cerebellum and MRI 
      revealed diffuse signal abnormality of the cerebellar parenchyma. This 
      neuro-imaging evidence for selective early involvement of the cerebellum is 
      consistent with both the typical presenting symptoms and the gross pathological 
      findings in the disorder. Neuroimaging may aid in differentiation of INAD from 
      other neurodegenerative disorders with onset in late infancy, providing impetus 
      for diagnostic biopsy and early genetic counseling.
FAU - Barlow, J K
AU  - Barlow JK
AD  - Department of Child Neurology, Massachusetts General Hospital, Boston 02114.
FAU - Sims, K B
AU  - Sims KB
FAU - Kolodny, E H
AU  - Kolodny EH
LA  - eng
PT  - Case Reports
PT  - Journal Article
PL  - United States
TA  - Ann Neurol
JT  - Annals of neurology
JID - 7707449
SB  - IM
MH  - Atrophy
MH  - Brain Diseases/diagnosis/diagnostic imaging/*pathology
MH  - Cerebellum/*pathology
MH  - *Diseases in Twins
MH  - Female
MH  - Humans
MH  - Infant
MH  - Magnetic Resonance Imaging
MH  - Peripheral Nervous System Diseases/diagnosis/diagnostic imaging/*pathology
MH  - Tomography, X-Ray Computed
MH  - Twins, Dizygotic
EDAT- 1989/04/01 00:00
MHDA- 1989/04/01 00:01
CRDT- 1989/04/01 00:00
PHST- 1989/04/01 00:00 [pubmed]
PHST- 1989/04/01 00:01 [medline]
PHST- 1989/04/01 00:00 [entrez]
AID - 10.1002/ana.410250416 [doi]
PST - ppublish
SO  - Ann Neurol. 1989 Apr;25(4):413-5. doi: 10.1002/ana.410250416.