PMID- 25406951
OWN - NLM
STAT- MEDLINE
DCOM- 20150629
LR  - 20240321
IS  - 1758-2652 (Electronic)
IS  - 1758-2652 (Linking)
VI  - 17
IP  - 1
DP  - 2014
TI  - Low adverse event rates following voluntary medical male circumcision in a high 
      HIV disease burden public sector prevention programme in South Africa.
PG  - 19275
LID - 10.7448/IAS.17.1.19275 [doi]
LID - 19275 [doi]
AB  - INTRODUCTION: The provision of voluntary medical male circumcision (VMMC) 
      services was piloted in three public sector facilities in a high HIV disease 
      burden, low circumcision rate province in South Africa to inform policy and 
      operational guidance for scale-up of the service for HIV prevention. We report on 
      adverse events (AEs) experienced by clients following the circumcision procedure. 
      METHODS: Prospective recruitment of HIV-negative males aged 12 and older 
      volunteering to be circumcised at three select public health facilities in 
      KwaZulu-Natal between November 2010 and May 2011. Volunteers underwent 
      standardized medical screening including a physical assessment prior to the 
      surgical procedure being performed. AEs were monitored at three time intervals 
      over a 21-day period post-operatively to determine safety outcomes in this pilot 
      demonstration programme. RESULTS: A total of 602 volunteers participated in this 
      study. The median age of the volunteers was 22 years (range 12-56). Most 
      participants (75.6%) returned for the 48-hour post-operative visit; 51.0% for day 
      seven visit and 26.1% for the 21st day visit. Participants aged 20-24 were most 
      likely to return. The AE rate was 0.2% intra-operatively. The frequency of 
      moderate AEs was 0.7, 0.3 and 0.6% at 2-, 7- and 21-day visits, respectively. The 
      frequency of severe AEs was 0.4, 0.3 and 0.6% at 2-, 7- and 21-day visits, 
      respectively. Swelling and wound infection were the most common AEs with mean 
      appearance duration of seven days. Clients aged between 35 and 56 years presented 
      with most AEs (3.0%). CONCLUSIONS: VMMC can be delivered safely at 
      resource-limited settings. The intensive three-visit post-operative review 
      practice may be unfeasible due to high attrition rates over time, particularly 
      amongst older men.
FAU - Phili, Rogerio
AU  - Phili R
AD  - Department of Public Health Medicine, University of KwaZulu-Natal, Durban, South 
      Africa; roger.phili@yahoo.com.
FAU - Abdool-Karim, Quarraisha
AU  - Abdool-Karim Q
AD  - Centre for the AIDS Programme of Research in South Africa (CAPRISA), Durban, 
      South Africa.
FAU - Ngesa, Oscar
AU  - Ngesa O
AD  - School of Mathematics, Statistics and Computer Science, University of 
      KwaZulu-Natal, Pietermarizburg, South Africa.
LA  - eng
GR  - D43TW000231-16S1/TW/FIC NIH HHS/United States
GR  - PEPFAR/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20141117
PL  - Switzerland
TA  - J Int AIDS Soc
JT  - Journal of the International AIDS Society
JID - 101478566
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Child
MH  - Circumcision, Male/*adverse effects
MH  - Delivery of Health Care/organization & administration
MH  - HIV Infections/*prevention & control
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Prospective Studies
MH  - Public Health Practice
MH  - South Africa
MH  - Young Adult
PMC - PMC4236629
OTO - NOTNLM
OT  - HIV prevention
OT  - adverse events
OT  - follow-up visit
OT  - medical male circumcision
EDAT- 2014/11/20 06:00
MHDA- 2015/06/30 06:00
PMCR- 2014/11/17
CRDT- 2014/11/20 06:00
PHST- 2014/05/13 00:00 [received]
PHST- 2014/09/09 00:00 [revised]
PHST- 2014/09/29 00:00 [accepted]
PHST- 2014/11/20 06:00 [entrez]
PHST- 2014/11/20 06:00 [pubmed]
PHST- 2015/06/30 06:00 [medline]
PHST- 2014/11/17 00:00 [pmc-release]
AID - 19275 [pii]
AID - 10.7448/IAS.17.1.19275 [doi]
PST - epublish
SO  - J Int AIDS Soc. 2014 Nov 17;17(1):19275. doi: 10.7448/IAS.17.1.19275. eCollection 
      2014.