PMID- 25407434
OWN - NLM
STAT- MEDLINE
DCOM- 20150720
LR  - 20181113
IS  - 1523-1747 (Electronic)
IS  - 0022-202X (Linking)
VI  - 135
IP  - 5
DP  - 2015 May
TI  - The role of human dendritic cells in HIV-1 infection.
PG  - 1225-1233
LID - S0022-202X(15)37260-2 [pii]
LID - 10.1038/jid.2014.490 [doi]
AB  - Dendritic cells (DCs) and their subsets have multifaceted roles in the early 
      stages of HIV-1 transmission and infection. DC studies have led to remarkable 
      discoveries, including identification of restriction factors, cellular structures 
      promoting viral transmission including the infectious synapse or the interplay of 
      the C-type lectins, Langerin on Langerhans cells (LCs), and dendritic 
      cell-specific intercellular adhesion molecule-3-grabbing non-integrin on other DC 
      subsets, limiting or facilitating HIV transmission to CD4(+) T cells, 
      respectively. LCs/DCs are also exposed to encountering HIV-1 and other sexually 
      transmitted infections (herpes simplex virus-2, bacteria, fungi), which reprogram 
      HIV-1 interaction with these cells. This review will summarize advances in the 
      role of DCs during HIV-1 infection and discuss their potential involvement in the 
      development of preventive strategies against HIV-1 and other sexually transmitted 
      infections.
FAU - Ahmed, Zahra
AU  - Ahmed Z
AD  - Department of Dermatology, Institute of Infection and Immunity, School of 
      Medicine, Cardiff University, University Hospital of Wales, Glamorgan House, 
      Heath Park, Cardiff, UK.
FAU - Kawamura, Tatsuyoshi
AU  - Kawamura T
AD  - Faculty of Medicine, Department of Dermatology, University of Yamanashi, 
      Yamanashi, Japan.
FAU - Shimada, Shinji
AU  - Shimada S
AD  - Faculty of Medicine, Department of Dermatology, University of Yamanashi, 
      Yamanashi, Japan.
FAU - Piguet, Vincent
AU  - Piguet V
AD  - Department of Dermatology, Institute of Infection and Immunity, School of 
      Medicine, Cardiff University, University Hospital of Wales, Glamorgan House, 
      Heath Park, Cardiff, UK. Electronic address: piguetv@cardiff.ac.uk.
LA  - eng
GR  - 506398/Wellcome Trust/United Kingdom
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20141119
PL  - United States
TA  - J Invest Dermatol
JT  - The Journal of investigative dermatology
JID - 0426720
RN  - 0 (Viral Vaccines)
SB  - IM
MH  - Cell Communication/physiology
MH  - Dendritic Cells/*physiology
MH  - HIV Infections/*physiopathology/prevention & control/transmission
MH  - *HIV-1
MH  - Humans
MH  - Langerhans Cells/physiology
MH  - Viral Vaccines/therapeutic use
EDAT- 2014/11/20 06:00
MHDA- 2015/07/21 06:00
CRDT- 2014/11/20 06:00
PHST- 2014/03/17 00:00 [received]
PHST- 2014/08/25 00:00 [revised]
PHST- 2014/09/27 00:00 [accepted]
PHST- 2014/11/20 06:00 [entrez]
PHST- 2014/11/20 06:00 [pubmed]
PHST- 2015/07/21 06:00 [medline]
AID - S0022-202X(15)37260-2 [pii]
AID - 10.1038/jid.2014.490 [doi]
PST - ppublish
SO  - J Invest Dermatol. 2015 May;135(5):1225-1233. doi: 10.1038/jid.2014.490. Epub 
      2014 Nov 19.