PMID- 25408911
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20141121
LR  - 20200930
IS  - 2049-9256 (Print)
IS  - 2049-9256 (Electronic)
IS  - 2049-9256 (Linking)
VI  - 1
IP  - 1
DP  - 2013
TI  - Neurotrophin levels at admission did not change significantly upon alcohol 
      deprivation and were positively correlated with the BMI and LDL levels.
PG  - 20
LID - 10.1186/2049-9256-1-20 [doi]
LID - 20
AB  - BACKGROUND: The neurotrophins brain-derived neurotrophic factor (BDNF) and 
      neurotrophic factor 3 (NT3) could play a role in addictive behavior. Interactions 
      between BDNF and dopamine transmission influence the alcohol intake. It has been 
      hypothesized that extensive alcohol consumption leads to diminished circulating 
      BDNF levels and impaired BDNF-mediated protective mechanisms. What is more, 
      alcohol dependency causes changes in lipid metabolism which in turn may influence 
      the neurotrophin system. METHODS: In this study, we tested the hypothesis that 
      alcohol withdrawal increases the serum levels of BDNF in alcoholic patients and 
      investigated correlations between serum BDNF and NT3 and alcohol in breath as 
      well as with the body-mass-index (BMI), lipoprotein profiles and lifestyle 
      factors in 110 male in-patients diagnosed with alcohol addiction on the first day 
      after admission and at discharge. RESULTS: The intoxication level (alcohol in 
      breath at admission) was significantly correlated with liver enzymes and BDNF 
      concentrations (R = .28; p = .004). Patients with positive breath-alcohol test at 
      admission had about 9 times higher NT3 levels and higher liver enzyme 
      concentration levels than nonintoxicated subjects. Alcohol intoxicated patients 
      with pathological aspartate aminase (ASAT) levels had even higher NT3 level 
      (F = 5.41; p = .022). The concentration of NT3 was positively associated with the 
      (BMI) (admission R = .36; p = .004; discharge R = .33; p = .001), and the obese 
      patients had 3 to 5 times higher NT3 concentration than the others. Low-density 
      lipoprotein (LDL) concentration levels were found to positively correlate with 
      NT3 concentration levels (admission R = .025; p = .015 discharge R = .24; 
      p = .23). CONCLUSION: Other than expected, the levels of NT3 and to a lesser 
      extent BDNF levels, were found to be significantly increased in acute alcohol 
      abuse. Alcohol deprivation did not significantly change the serum neurotrophin 
      levels at admission. NT3 levels were positively correlated with the BMI and LDL 
      levels. Because of expected difference between genders, we recommend 
      investigating these correlations further in patients of both genders.
FAU - Popa-Wagner, Aurel
AU  - Popa-Wagner A
AD  - Clinic for Psychiatry and Psychotheraphy, University of Medicine Rostock, 
      Rostock, Germany.
FAU - Furczyk, Karolina
AU  - Furczyk K
AD  - Clinic for Psychiatry and Psychotheraphy, University of Medicine Rostock, 
      Rostock, Germany.
FAU - Richter, Joerg
AU  - Richter J
AD  - Norway Centre for Child and Adolescent Mental Health Eastern and Southern Norway, 
      Oslo, 0405 Norway.
FAU - Irmisch, Gisela
AU  - Irmisch G
AD  - Clinic for Psychiatry and Psychotheraphy, University of Medicine Rostock, 
      Rostock, Germany.
FAU - Thome, Johannes
AU  - Thome J
AD  - Clinic for Psychiatry and Psychotheraphy, University of Medicine Rostock, 
      Rostock, Germany.
LA  - eng
PT  - Journal Article
DEP - 20131202
PL  - England
TA  - J Mol Psychiatry
JT  - Journal of molecular psychiatry
JID - 101622179
PMC - PMC4223886
OTO - NOTNLM
OT  - Alcoholism
OT  - Brain-derived neurotrophic factor
OT  - Detoxification
OT  - Lipoproteins
OT  - Neurotrophin-derived factor 3
EDAT- 2013/01/01 00:00
MHDA- 2013/01/01 00:01
PMCR- 2013/12/02
CRDT- 2014/11/20 06:00
PHST- 2012/11/11 00:00 [received]
PHST- 2013/11/05 00:00 [accepted]
PHST- 2014/11/20 06:00 [entrez]
PHST- 2013/01/01 00:00 [pubmed]
PHST- 2013/01/01 00:01 [medline]
PHST- 2013/12/02 00:00 [pmc-release]
AID - 18 [pii]
AID - 10.1186/2049-9256-1-20 [doi]
PST - epublish
SO  - J Mol Psychiatry. 2013 Dec 2;1(1):20. doi: 10.1186/2049-9256-1-20. eCollection 
      2013.