PMID- 2540937
OWN - NLM
STAT- MEDLINE
DCOM- 19890622
LR  - 20190828
IS  - 0271-3683 (Print)
IS  - 0271-3683 (Linking)
VI  - 8
IP  - 2
DP  - 1989 Feb
TI  - Prostaglandin F2 alpha isopropyl ester versus iloprost phenacyl ester in rabbit 
      and beagle eyes.
PG  - 131-8
AB  - One and 2 micrograms of prostaglandin F2 alpha isopropyl ester (PGF2 alpha -IE) 
      applied topically to the rabbit eye caused a biphasic response. The hypotensive 
      phase was dose-dependent with a maximum reduction in intraocular pressure (IOP) 
      of 9.4 +/- 1.7 mmHg at a dose of 2 micrograms. In beagles, 0.4 to 2 micrograms 
      topical PGF2 alpha-IE resulted in a sustained IOP reduction; 2 micrograms 
      produced the maximum reduction of 7-9 mmHg. No initial hypertensive response was 
      observed. Iloprost phenacyl ester (Iloprost-PE) caused a greater decrease in IOP 
      when dissolved in 0.5% hydroxypropyl methylcellulose (AT) than in saline. In 
      rabbits, doses of 0.1 to 1 microgram in AT caused a biphasic response with a 
      sustained IOP decrease fluctuating between 7 and 8 mmHg. In beagles 1 and 2 
      micrograms Iloprost-PE resulted in a mean IOP reduction of 5.8 +/- 0.4 mmHg and 
      5.8 +/- 0.5 mmHg (P less than 0.005), respectively; the decrease persisted for 5 
      hrs. No initial hypertensive response was observed. In beagles PGF2 alpha-IE 
      induced a strong miosis lasting more than 6 hours; Iloprost-PE had no effect on 
      pupil size. Both PG-esters induced a slight hyperemia in rabbit and beagle eyes. 
      In rabbits Iloprost-PE affects the blood-aqueous barrier more than PGF2 alpha-IE, 
      since higher protein concentrations are seen in the aqueous humor after 
      application of Iloprost-PE. Neither PG-ester had a noticeable effect on aqueous 
      protein in beagles. In rabbits, both PG-esters led to slightly increased aqueous 
      humor cyclic-AMP concentrations. In beagles aqueous humor cyclic-AMP was elevated 
      only after Iloprost-PE.(ABSTRACT TRUNCATED AT 250 WORDS)
FAU - Groeneboer, M C
AU  - Groeneboer MC
AD  - Netherlands Ophthalmic Research Institute, Department of Experimental 
      Ophthalmology, Amsterdam.
FAU - Hoyng, P F
AU  - Hoyng PF
FAU - Kuizenga, A
AU  - Kuizenga A
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PL  - England
TA  - Curr Eye Res
JT  - Current eye research
JID - 8104312
RN  - 122405-30-5 (iloprost phenacyl ester)
RN  - 3NXW29V3WO (Hypromellose Derivatives)
RN  - 53764-90-2 (prostaglandin F2 isopropyl ester)
RN  - 9004-67-5 (Methylcellulose)
RN  - B7IN85G1HY (Dinoprost)
RN  - DCR9Z582X0 (Epoprostenol)
RN  - E0399OZS9N (Cyclic AMP)
RN  - JED5K35YGL (Iloprost)
SB  - IM
MH  - Administration, Topical
MH  - Animals
MH  - Aqueous Humor/analysis
MH  - Cyclic AMP/analysis
MH  - Dinoprost/*analogs & derivatives/pharmacology
MH  - Dogs
MH  - Dose-Response Relationship, Drug
MH  - Epoprostenol/*pharmacology
MH  - Hyperemia
MH  - Hypromellose Derivatives
MH  - *Iloprost/*analogs & derivatives
MH  - Intraocular Pressure/*drug effects
MH  - Methylcellulose/analogs & derivatives/analysis
MH  - Pupil/drug effects
MH  - Rabbits
MH  - Time Factors
MH  - Tonometry, Ocular
EDAT- 1989/02/01 00:00
MHDA- 1989/02/01 00:01
CRDT- 1989/02/01 00:00
PHST- 1989/02/01 00:00 [pubmed]
PHST- 1989/02/01 00:01 [medline]
PHST- 1989/02/01 00:00 [entrez]
AID - 10.3109/02713688908995184 [doi]
PST - ppublish
SO  - Curr Eye Res. 1989 Feb;8(2):131-8. doi: 10.3109/02713688908995184.