PMID- 2541026
OWN - NLM
STAT- MEDLINE
DCOM- 19890620
LR  - 20191022
IS  - 0950-821X (Print)
IS  - 0950-821X (Linking)
VI  - 3
IP  - 2
DP  - 1989 Apr
TI  - The effect of a bolus injection of unfractionated or low molecular weight heparin 
      during aortobifemoral bypass grafting.
PG  - 121-6
AB  - Eighteen patients undergoing aortobifemoral graft surgery for severe aortoiliac 
      atherosclerotic disease received a bolus injection of 10,000 anti-Xa units of 
      either unfractionated heparin (UFH) or low molecular weight heparin (LMWH) into 
      the distal aorta as prophylaxis against thromboembolic complications related to 
      clamping. Heparin activity was measured by factor Xa inhibition and by 
      prolongation of the APTT. In both groups there was a delay before peak levels of 
      heparin were observed. In the LMWH group, this amounted to 30 min. In the UFH 
      group, APTT was prolonged by 46 s, 7 min after injection but only by 5 s at the 
      end of the operation. In contrast, in the LMWH group, the prolongation in APTT 7 
      min after injection was less (34 s) but more sustained since a 12.5 s 
      prolongation was still present at the end of the operation. During surgery, 
      heparin activity exceeded 0.7 U/ml in the LMWH group, compared to significantly 
      lower levels in the UFH group (less than or equal to 0.20 U/ml). By the end of 
      the operation no heparin activity was detectable in the UFH group. Protein C 
      antigen decreased after heparin injection and this fall was more pronounced in 
      the UFH group. The level of C1q (a subcomponent of the first component of the 
      complement system) was decreased in the UFH group (P less than 0.04), whereas in 
      the LMWH group C1q levels increased. Platelet aggregation with collagen was 
      inhibited to a significantly greater degree in the LMWH group than the UFH group 
      (54% compared with 23%) (P less than 0.01).(ABSTRACT TRUNCATED AT 250 WORDS)
FAU - Melissari, E
AU  - Melissari E
AD  - Thrombosis Research Unit, King's College School of Medicine & Dentistry, Denmark 
      Hill, London, U.K.
FAU - Stringer, M D
AU  - Stringer MD
FAU - Kakkar, V V
AU  - Kakkar VV
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PL  - England
TA  - Eur J Vasc Surg
JT  - European journal of vascular surgery
JID - 8709440
RN  - 0 (Complement C1)
RN  - 0 (Heparin, Low-Molecular-Weight)
RN  - 0 (Platelet Aggregation Inhibitors)
RN  - 0 (Protein C)
RN  - 80295-33-6 (Complement C1q)
RN  - 9005-49-6 (Heparin)
RN  - EC 3.- (Complement Activating Enzymes)
SB  - IM
MH  - Aged
MH  - Aorta, Abdominal/*surgery
MH  - *Blood Vessel Prosthesis
MH  - Complement Activating Enzymes
MH  - Complement C1
MH  - Complement C1q
MH  - Femoral Artery/*surgery
MH  - Heparin/*therapeutic use
MH  - Heparin, Low-Molecular-Weight/*therapeutic use
MH  - Humans
MH  - Intraoperative Complications/prevention & control
MH  - Middle Aged
MH  - Platelet Aggregation/drug effects
MH  - Platelet Aggregation Inhibitors/pharmacology
MH  - Protein C/antagonists & inhibitors
MH  - Thromboembolism/prevention & control
EDAT- 1989/04/01 00:00
MHDA- 1989/04/01 00:01
CRDT- 1989/04/01 00:00
PHST- 1989/04/01 00:00 [pubmed]
PHST- 1989/04/01 00:01 [medline]
PHST- 1989/04/01 00:00 [entrez]
AID - 10.1016/s0950-821x(89)80006-4 [doi]
PST - ppublish
SO  - Eur J Vasc Surg. 1989 Apr;3(2):121-6. doi: 10.1016/s0950-821x(89)80006-4.