PMID- 25411442 OWN - NLM STAT- MEDLINE DCOM- 20150901 LR - 20210217 IS - 1539-7262 (Electronic) IS - 0022-2275 (Print) IS - 0022-2275 (Linking) VI - 56 IP - 1 DP - 2015 Jan TI - Dietary DHA during development affects depression-like behaviors and biomarkers that emerge after puberty in adolescent rats. PG - 151-66 LID - 10.1194/jlr.M055558 [doi] AB - DHA is an important omega-3 PUFA that confers neurodevelopmental benefits. Sufficient omega-3 PUFA intake has been associated with improved mood-associated measures in adult humans and rodents, but it is unknown whether DHA specifically influences these benefits. Furthermore, the extent to which development and puberty interact with the maternal diet and the offspring diet to affect mood-related behaviors in adolescence is poorly understood. We sought to address these questions by 1) feeding pregnant rats with diets sufficient or deficient in DHA during gestation and lactation; 2) weaning their male offspring to diets that were sufficient or deficient in DHA; and 3) assessing depression-related behaviors (forced swim test), plasma biomarkers [brain-derived neurotrophic factor (BDNF), serotonin, and melatonin], and brain biomarkers (BDNF) in the offspring before and after puberty. No dietary effects were detected when the offspring were evaluated before puberty. In contrast, after puberty depressive-like behavior and its associated biomarkers were worse in DHA-deficient offspring compared with animals with sufficient levels of DHA. The findings reported here suggest that maintaining sufficient DHA levels throughout development (both pre- and postweaning) may increase resiliency to emotional stressors and decrease susceptibility to mood disorders that commonly arise during adolescence. CI - Copyright (c) 2015 by the American Society for Biochemistry and Molecular Biology, Inc. FAU - Weiser, Michael J AU - Weiser MJ AD - Human Nutrition and Health (HNH)-Biological Models, DSM Nutritional Products, Boulder, CO 80301. FAU - Wynalda, Kelly AU - Wynalda K AD - Human Nutrition and Health (HNH)-Biological Models, DSM Nutritional Products, Boulder, CO 80301. FAU - Salem, Norman Jr AU - Salem N Jr AD - Nutritional Lipids, DSM Nutritional Products, Columbia, MD 21045. FAU - Butt, Christopher M AU - Butt CM AD - Human Nutrition and Health (HNH)-Biological Models, DSM Nutritional Products, Boulder, CO 80301. LA - eng PT - Journal Article DEP - 20141119 PL - United States TA - J Lipid Res JT - Journal of lipid research JID - 0376606 RN - 0 (Biomarkers) RN - 0 (Brain-Derived Neurotrophic Factor) RN - 0 (Dietary Fats, Unsaturated) RN - 25167-62-8 (Docosahexaenoic Acids) RN - 333DO1RDJY (Serotonin) RN - 3XMK78S47O (Testosterone) RN - JL5DK93RCL (Melatonin) SB - IM MH - Animals MH - Behavior, Animal/*drug effects MH - Biomarkers/blood MH - Body Weight/drug effects MH - Brain/drug effects/growth & development/metabolism MH - Brain-Derived Neurotrophic Factor/blood/metabolism MH - Depression/blood/metabolism/*prevention & control MH - Dietary Fats, Unsaturated/*pharmacology MH - Dietary Supplements MH - Docosahexaenoic Acids/*pharmacology MH - Female MH - Growth and Development/*drug effects MH - Male MH - Melatonin/blood MH - Organ Size/drug effects MH - Pregnancy MH - Rats MH - Rats, Sprague-Dawley MH - Serotonin/blood MH - Testosterone/blood PMC - PMC4274063 OTO - NOTNLM OT - adolescence OT - brain lipids OT - diet and dietary lipids OT - nutrition OT - omega-3 fatty acids OT - pregnancy EDAT- 2014/11/21 06:00 MHDA- 2015/09/02 06:00 PMCR- 2016/01/01 CRDT- 2014/11/21 06:00 PHST- 2014/11/21 06:00 [entrez] PHST- 2014/11/21 06:00 [pubmed] PHST- 2015/09/02 06:00 [medline] PHST- 2016/01/01 00:00 [pmc-release] AID - S0022-2275(20)35648-0 [pii] AID - m055558 [pii] AID - 10.1194/jlr.M055558 [doi] PST - ppublish SO - J Lipid Res. 2015 Jan;56(1):151-66. doi: 10.1194/jlr.M055558. Epub 2014 Nov 19.