PMID- 25413265
OWN - NLM
STAT- MEDLINE
DCOM- 20150629
LR  - 20150415
IS  - 1421-9662 (Electronic)
IS  - 0001-5792 (Linking)
VI  - 133
IP  - 3
DP  - 2015
TI  - Equivalent outcome of autologous stem cell transplantation and reduced intensity 
      conditioning stem cell transplantation in acute myeloid leukemia patients with 
      t(8;21).
PG  - 266-76
LID - 10.1159/000366261 [doi]
AB  - We analyzed the outcome of stem cell transplantation (SCT) for 59 acute myeloid 
      leukemia (AML) patients with t(8;21). The 5-year overall and disease-free 
      survival (OS and DFS) were 70.2 and 68.4%, respectively. The 5-year cumulative 
      incidence of relapse (CIR) and nonrelapse mortality were 16.9 and 13.6%, 
      respectively. OS and DFS in the reduced-intensity conditioning (RIC)-SCT group 
      (70.4%) were not different from in the autologous SCT (ASCT) group (72.4 and 
      69.0%, respectively). Age was a factor affecting OS (p = 0.007) and DFS (p = 
      0.008) in the ASCT group, but not in the RIC-SCT group. In the ASCT group, lack 
      of the X chromosome (-X) and an age of >50 years were associated with inferior 
      survival; however, these differences disappeared in the RIC-SCT group. CIR was 
      significantly higher in patients with -X than in those without -X only in the 
      ASCT group (p = 0.038), i.e. not in the RIC-SCT group. ASCT and RIC-SCT are 
      equally effective for the intensification of postremission treatment of AML 
      patients with t(8;21). The subgroups with advanced age or -X should be 
      preferentially considered for RIC-SCT, rather than ASCT. Further investigations 
      with randomized prospective trials of a sizeable study population are warranted.
FAU - Eom, Ki-Seong
AU  - Eom KS
AD  - Division of Hematology, Department of Internal Medicine, Catholic Blood and 
      Marrow Transplantation Center, Seoul St. Mary's Hospital, Seoul, Republic of 
      Korea.
FAU - Kim, Hee-Je
AU  - Kim HJ
FAU - Cho, Byung-Sik
AU  - Cho BS
FAU - Lee, Sung Eun
AU  - Lee SE
FAU - Yahng, Seung-Ah
AU  - Yahng SA
FAU - Yoon, Jae-Ho
AU  - Yoon JH
FAU - Shin, Seung-Hwan
AU  - Shin SH
FAU - Jeon, Young-Woo
AU  - Jeon YW
FAU - Kim, Jung-Ho
AU  - Kim JH
FAU - Kim, Yoo-Jin
AU  - Kim YJ
FAU - Lee, Seok
AU  - Lee S
FAU - Min, Chang-Ki
AU  - Min CK
FAU - Cho, Seok-Goo
AU  - Cho SG
FAU - Kim, Dong-Wook
AU  - Kim DW
FAU - Lee, Jong-Wook
AU  - Lee JW
FAU - Min, Woo-Sung
AU  - Min WS
FAU - Park, Chong-Won
AU  - Park CW
LA  - eng
PT  - Clinical Trial
PT  - Journal Article
DEP - 20141120
PL  - Switzerland
TA  - Acta Haematol
JT  - Acta haematologica
JID - 0141053
SB  - IM
CIN - Acta Haematol. 2015;133(3):264-5. PMID: 25413185
MH  - Adolescent
MH  - Adult
MH  - Autografts
MH  - Chromosomes, Human, Pair 21/*genetics
MH  - Chromosomes, Human, Pair 8/*genetics
MH  - Disease-Free Survival
MH  - Female
MH  - Humans
MH  - Incidence
MH  - *Leukemia, Myeloid, Acute/genetics/mortality/therapy
MH  - Male
MH  - Middle Aged
MH  - Recurrence
MH  - *Stem Cell Transplantation
MH  - Survival Rate
MH  - *Translocation, Genetic
MH  - *Transplantation Conditioning
EDAT- 2014/11/22 06:00
MHDA- 2015/06/30 06:00
CRDT- 2014/11/22 06:00
PHST- 2014/05/21 00:00 [received]
PHST- 2014/07/31 00:00 [accepted]
PHST- 2014/11/22 06:00 [entrez]
PHST- 2014/11/22 06:00 [pubmed]
PHST- 2015/06/30 06:00 [medline]
AID - 000366261 [pii]
AID - 10.1159/000366261 [doi]
PST - ppublish
SO  - Acta Haematol. 2015;133(3):266-76. doi: 10.1159/000366261. Epub 2014 Nov 20.