PMID- 25414196
OWN - NLM
STAT- MEDLINE
DCOM- 20150302
LR  - 20141216
IS  - 1552-5783 (Electronic)
IS  - 0146-0404 (Linking)
VI  - 55
IP  - 12
DP  - 2014 Nov 20
TI  - Additive diagnostic role of imaging in glaucoma: optical coherence tomography and 
      retinal nerve fiber layer photography.
PG  - 8024-30
LID - 10.1167/iovs.14-15237 [doi]
AB  - PURPOSE: To investigate the additive diagnostic role of spectral-domain optical 
      coherence tomography (SD-OCT) and red-free retinal nerve fiber layer photography 
      (RNFLP) in making clinical glaucoma diagnosis. METHODS: Four diagnostic 
      combination sets, including the most recent image from each measurement of 196 
      glaucoma eyes (including the 44 preperimetric glaucoma eyes) and 101 healthy 
      eyes, were prepared: (1) stereo disc photography and Humphrey visual field (SH), 
      (2) SH and SD-OCT (SHO), (3) SH and RNFLP (SHR), and (4) SHR and SD-OCT (SHRO). 
      Each randomly sorted set was serially presented at 1-month intervals to five 
      glaucoma specialists who were asked to evaluate them in a subjective and 
      independent manner. The specialists' glaucoma-diagnostic performances based on 
      the sets were then compared. RESULTS: For each specialist, adding SD-OCT to SH or 
      SHR increased the glaucoma-diagnostic sensitivity but not to a level of 
      statistical significance. For one specialist, adding RNFLP to SH significantly 
      increased the sensitivity. Each specialist showed a high level of specificity 
      regardless of the diagnostic set. The overall sensitivity of all specialists' 
      assessments was significantly increased by adding RNFLP or the combination of 
      SD-OCT and RNFLP to SH (P < 0.001); however, adding SD-OCT to SH or SHR did not 
      significantly increase the sensitivity. A similar relationship was noted also for 
      the preperimetric glaucoma subgroup. CONCLUSIONS: In contrast to RNFLP, SD-OCT 
      did not significantly enhance the diagnostic accuracy of detecting glaucoma or 
      even of preperimetric glaucoma. Our results suggest that, at least for glaucoma 
      specialists, the additive diagnostic role of OCT is limited.
CI  - Copyright 2014 The Association for Research in Vision and Ophthalmology, Inc.
FAU - Kim, Ko Eun
AU  - Kim KE
AD  - Department of Ophthalmology, Seoul National University College of Medicine, 
      Seoul, Korea Department of Ophthalmology, Seoul National University Hospital, 
      Seoul, Korea.
FAU - Kim, Seok Hwan
AU  - Kim SH
AD  - Department of Ophthalmology, Seoul National University College of Medicine, 
      Seoul, Korea Department of Ophthalmology, Seoul National University Boramae 
      Hospital, Seoul, Korea.
FAU - Oh, Sohee
AU  - Oh S
AD  - Department of Biostatistics, Seoul National University Boramae Hospital, Seoul, 
      Korea.
FAU - Jeoung, Jin Wook
AU  - Jeoung JW
AD  - Department of Ophthalmology, Seoul National University College of Medicine, 
      Seoul, Korea Department of Ophthalmology, Seoul National University Hospital, 
      Seoul, Korea.
FAU - Suh, Min Hee
AU  - Suh MH
AD  - Department of Ophthalmology, Haeundae Paik Hospital, Inje University College of 
      Medicine, Busan, Korea.
FAU - Seo, Je Hyun
AU  - Seo JH
AD  - Department of Ophthalmology, Pusan National University Yangsan Hospital, Busan, 
      Korea.
FAU - Kim, Martha
AU  - Kim M
AD  - Department of Ophthalmology, Dongguk University Ilsan Hospital, Goyang, Korea.
FAU - Park, Ki Ho
AU  - Park KH
AD  - Department of Ophthalmology, Seoul National University College of Medicine, 
      Seoul, Korea Department of Ophthalmology, Seoul National University Hospital, 
      Seoul, Korea.
FAU - Kim, Dong Myung
AU  - Kim DM
AD  - Department of Ophthalmology, Seoul National University College of Medicine, 
      Seoul, Korea Department of Ophthalmology, Seoul National University Hospital, 
      Seoul, Korea.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20141120
PL  - United States
TA  - Invest Ophthalmol Vis Sci
JT  - Investigative ophthalmology & visual science
JID - 7703701
SB  - IM
MH  - Adult
MH  - Aged
MH  - Analysis of Variance
MH  - Case-Control Studies
MH  - Female
MH  - Glaucoma/*diagnosis
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Nerve Fibers/*pathology
MH  - Photography/*methods
MH  - Retinal Ganglion Cells/*pathology
MH  - Sensitivity and Specificity
MH  - Tomography, Optical Coherence/*methods
MH  - Visual Fields/physiology
OTO - NOTNLM
OT  - additive diagnostic role
OT  - glaucoma diagnosis
OT  - glaucoma specialist
OT  - retinal nerve fiber layer photography
OT  - spectral-domain optical coherence tomography
EDAT- 2014/11/22 06:00
MHDA- 2015/03/03 06:00
CRDT- 2014/11/22 06:00
PHST- 2014/11/22 06:00 [entrez]
PHST- 2014/11/22 06:00 [pubmed]
PHST- 2015/03/03 06:00 [medline]
AID - iovs.14-15237 [pii]
AID - 10.1167/iovs.14-15237 [doi]
PST - epublish
SO  - Invest Ophthalmol Vis Sci. 2014 Nov 20;55(12):8024-30. doi: 
      10.1167/iovs.14-15237.