PMID- 25414542
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20201001
IS  - 0883-1874 (Print)
IS  - 1557-7767 (Electronic)
IS  - 0883-1874 (Linking)
VI  - 22
IP  - 3
DP  - 2009
TI  - The Pro- and Anti-Inflammatory Cytokine Response to Exercise in Adolescent 
      Swimmers.
PG  - 95-100
AB  - OBJECTIVE: Whether or not individuals with allergy and asthma experience 
      different patterns of change in the balance of both pro- and anti-inflammatory 
      mediators with acute exercise is not known. We hypothesized that adolescent 
      swimmers with a clinical diagnosis of respiratory allergy would have an 
      exaggerated proinflammatory response to laboratory exercise relative to a 
      no-allergy comparison group. METHODS: Adolescent swimmers (17 with clinical 
      symptoms of respiratory allergy (CSRA) and 17 in comparison group) completed the 
      American Thoracic Society (ATS) exercise challenge on cycle ergometer. Blood was 
      collected at baseline and immediately post-exercise. All study tests were 
      conducted at the Institute for Clinical Translational Science at the University 
      of California, Irvine. Circulating cytokines, growth factors, and adhesion 
      molecules were measured using ELISAs including transforming growth factor-beta1 
      (TGF-beta1), tumor necrosis factor-alpha (TNF-alpha), interleukin-4 (IL-4), IL-6, IL-10, 
      P-selectin, and immunoglobulin E (IgE). RESULTS: There was a trend toward higher 
      resting levels of TNF-alpha in the CSRA group (P = 0.076). Exercise induced a 
      significant increase in P-selectin and TGF-beta1 in both groups. TNF-alpha increased 
      significantly (17%) in the comparison group (pre = 0.6, post = 0.7 pg/mL), but 
      not in the CSRA group. IL-6 increased significantly in the CSRA group (pre = 0.7, 
      post = 0.8 pg/mL), but not in the comparison group. Circulating levels of IL-4 
      and IL-10 were not altered immediately post-exercise in either group. 
      CONCLUSIONS: A short bout of intense exercise increased inflammatory growth 
      factors and adhesion molecules, namely TGF-beta1 and P-selectin, both of which are 
      known to be involved in allergic airway diseases. Differences in resting IL-6 and 
      TNF-alpha and exercise alterations in these cytokines may also contribute to allergic 
      disease in adolescent elite swimmers.
FAU - Wilson, Lori D
AU  - Wilson LD
AD  - Pediatric Exercise Research Center, University of California, Irvine, Orange, 
      California.
FAU - Zaldivar, Frank P
AU  - Zaldivar FP
AD  - Pediatric Exercise Research Center, University of California, Irvine, Orange, 
      California.
FAU - Schwindt, Christina D
AU  - Schwindt CD
AD  - Pediatric Exercise Research Center, University of California, Irvine, Orange, 
      California.
FAU - Cooper, Dan M
AU  - Cooper DM
AD  - Pediatric Exercise Research Center, University of California, Irvine, Orange, 
      California.
LA  - eng
GR  - M01 RR000827/RR/NCRR NIH HHS/United States
GR  - P01 HD048721/HD/NICHD NIH HHS/United States
GR  - R01 HL080947/HL/NHLBI NIH HHS/United States
GR  - T32 AR047752/AR/NIAMS NIH HHS/United States
PT  - Journal Article
PL  - United States
TA  - Pediatr Asthma Allergy Immunol
JT  - Pediatric asthma, allergy & immunology
JID - 8708372
PMC - PMC4235156
MID - NIHMS578438
EDAT- 2009/01/01 00:00
MHDA- 2009/01/01 00:01
PMCR- 2014/11/18
CRDT- 2014/11/22 06:00
PHST- 2014/11/22 06:00 [entrez]
PHST- 2009/01/01 00:00 [pubmed]
PHST- 2009/01/01 00:01 [medline]
PHST- 2014/11/18 00:00 [pmc-release]
AID - 10.1089/pai.2009.0013 [doi]
PST - ppublish
SO  - Pediatr Asthma Allergy Immunol. 2009;22(3):95-100. doi: 10.1089/pai.2009.0013.