PMID- 25414779
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20141121
LR  - 20200930
IS  - 1976-9148 (Print)
IS  - 2005-4483 (Electronic)
IS  - 1976-9148 (Linking)
VI  - 22
IP  - 5
DP  - 2014 Sep
TI  - Protective Effect of Arabinoxylan against Scopolamine-Induced Learning and Memory 
      Impairment.
PG  - 467-73
LID - 10.4062/biomolther.2014.063 [doi]
AB  - The purpose of this study is to investigate the memory enhancing effect and 
      underlying molecular mechanism of arabinoxylan (AX), a major component of dietary 
      fiber in wheat against scopolamine (SCO)-induced amnesia in Sprague-Dawley (SD) 
      rats. Diverse behavior tests including Y-maze, Morris water maze, and passive 
      avoidance tests were performed to measure cognitive functions. SCO significantly 
      decreased the spontaneous alterations in Y-maze test and step-through latency in 
      passive avoidance test, whereas increased time spent to find the hidden platform 
      in Morris water maze test compared with the sham control group. In contrast, oral 
      administration of AX (25 mg/kg and 50 mg/kg) effectively reversed the SCO-induced 
      cognitive impairments in SD rats. Furthermore, AX treatment up-regulated the 
      expression of brain-derived neurotrophic factor (BDNF) in the cortex and 
      hippo-campus via promoting activation of cAMP response element binding protein 
      (CREB). Therefore, our findings suggest that AX can improve SCO-induced learning 
      and memory impairment possibly through activation of CREB and up-regulation of 
      BDNF levels, thereby exhibiting a cognition-enhancing potential.
FAU - Kim, Chang-Yul
AU  - Kim CY
AD  - Department of Pathology, College of Oriental Medicine, Daegu Haany University, 
      Daegu 706-828.
FAU - Lee, Gil-Yong
AU  - Lee GY
AD  - Department of Pathology, College of Oriental Medicine, Daegu Haany University, 
      Daegu 706-828.
FAU - Park, Gyu Hwan
AU  - Park GH
AD  - Research Institute of Pharmaceutical Sciences, College of Pharmacy, Kyungpook 
      National University, Daegu 702-701.
FAU - Lee, Jongwon
AU  - Lee J
AD  - Deparment of Biochemistry, School of Medicine, Catholic University of Daegu, 
      Daegu 705-718.
FAU - Jang, Jung-Hee
AU  - Jang JH
AD  - Department of Pharmacology, School of Medicine, Keimyung University, Daegu 
      704-701, Republic of Korea.
LA  - eng
PT  - Journal Article
DEP - 20140930
PL  - Korea (South)
TA  - Biomol Ther (Seoul)
JT  - Biomolecules & therapeutics
JID - 101472832
PMC - PMC4201221
OTO - NOTNLM
OT  - Arabinoxylan
OT  - Brain-derived neurotrophic factor
OT  - Learning and memory
OT  - Scopolamine
OT  - cAMP response element binding protein
EDAT- 2014/11/22 06:00
MHDA- 2014/11/22 06:01
PMCR- 2014/09/01
CRDT- 2014/11/22 06:00
PHST- 2014/05/29 00:00 [received]
PHST- 2014/07/07 00:00 [revised]
PHST- 2014/07/08 00:00 [accepted]
PHST- 2014/11/22 06:00 [entrez]
PHST- 2014/11/22 06:00 [pubmed]
PHST- 2014/11/22 06:01 [medline]
PHST- 2014/09/01 00:00 [pmc-release]
AID - bt-22-467 [pii]
AID - 10.4062/biomolther.2014.063 [doi]
PST - ppublish
SO  - Biomol Ther (Seoul). 2014 Sep;22(5):467-73. doi: 10.4062/biomolther.2014.063. 
      Epub 2014 Sep 30.