PMID- 25415856
OWN - NLM
STAT- MEDLINE
DCOM- 20151008
LR  - 20150204
IS  - 1473-5830 (Electronic)
IS  - 0954-6928 (Linking)
VI  - 26
IP  - 2
DP  - 2015 Mar
TI  - Meta-analysis of coronary artery bypass graft surgery combined with stem cell 
      transplantation in the treatment of ischemic heart diseases.
PG  - 170-5
LID - 10.1097/MCA.0000000000000193 [doi]
AB  - OBJECTIVE: The use of bone marrow cells (BMCs) to regenerate the myocardium and 
      vessels is a new treatment for ischemic heart diseases (IHD) that has been 
      receiving attention. In this study, a meta-analysis was used to analyze the 
      efficacy of combining coronary artery bypass graft (CABG) surgery with BMC 
      transplantation in the treatment of IHD. METHODS AND RESULTS: MEDLINE, EMBASE, 
      Cochrane, CNKI, WAN-FANG, and WEI-PU databases were searched. The main inclusion 
      criteria were as follows: (a) studies that analyzed patients diagnosed with 
      chronic IHD. (b) Studies that had randomized-controlled trials. (c) Studies that 
      included research comparing the efficacy of CABG and CABG combined with bone BMC 
      transplantation in the treatment of IHD. (d) Studies with specific enumeration 
      data at the end of the follow-up with a follow-up time of at least 3 months. Nine 
      randomized trials were included. There were 158 patients in the group that 
      received the treatment of CABG surgery as well as stem cell transplantation, 
      referred to as the 'cell transplantation group.' A total of 147 patients were in 
      the group that only received the treatment of CABG surgery, referred to as the 
      'CABG group'. Our data show that not only did stem cell transplantation 
      significantly improve left ventricular ejection fraction (odds ratio=11.7, 95% 
      confidence interval: 4.04-19.36; P=0.003) but it also significantly reduced the 
      left ventricular end-diastolic volume and left ventricular end-systolic volume 
      (P<0.001). CONCLUSION: BMC transplantation is associated with a significant 
      improvement in left ventricular ejection fraction and the attenuation of left 
      ventricular remodeling.
FAU - Qin, Shu-Lan
AU  - Qin SL
AD  - aEndocrinology Department, The Third Affiliated Hospital of Nanchang University 
      bEndocrinology Department, The Nursing Vocational College of Jiangxi cExperiment 
      Center, The Second Affiliated Hospital of Nanchang University, Nanchang, China.
FAU - He, Chun-Yan
AU  - He CY
FAU - Xu, Jin-Song
AU  - Xu JS
FAU - Lai, Xiao-Yang
AU  - Lai XY
FAU - Liu, Shan-Shan
AU  - Liu SS
FAU - He, Wei-Ping
AU  - He WP
LA  - eng
PT  - Journal Article
PT  - Meta-Analysis
PL  - England
TA  - Coron Artery Dis
JT  - Coronary artery disease
JID - 9011445
SB  - IM
MH  - Aged
MH  - Bone Marrow Transplantation/*methods
MH  - Combined Modality Therapy
MH  - Coronary Artery Bypass/*methods
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Myocardial Ischemia/*surgery
EDAT- 2014/11/22 06:00
MHDA- 2015/10/09 06:00
CRDT- 2014/11/22 06:00
PHST- 2014/11/22 06:00 [entrez]
PHST- 2014/11/22 06:00 [pubmed]
PHST- 2015/10/09 06:00 [medline]
AID - 10.1097/MCA.0000000000000193 [doi]
PST - ppublish
SO  - Coron Artery Dis. 2015 Mar;26(2):170-5. doi: 10.1097/MCA.0000000000000193.