PMID- 25416463 OWN - NLM STAT- MEDLINE DCOM- 20180426 LR - 20181202 IS - 1557-1246 (Electronic) IS - 1087-0547 (Linking) VI - 21 IP - 12 DP - 2017 Oct TI - Is Maternal Smoking During Pregnancy a Risk Factor for Cigarette Smoking in Offspring? A Longitudinal Controlled Study of ADHD Children Grown Up. PG - 975-985 LID - 10.1177/1087054714557357 [doi] AB - OBJECTIVE: This study examined whether exposure to maternal smoking during pregnancy in children with and without ADHD is associated with smoking in offspring and whether this association is selective to ADHD children. METHOD: Ninety-six exposed and 400 unexposed participants were derived from two longitudinal studies of boys and girls with and without ADHD. Maternal smoking during pregnancy was defined by interviews with participants' mothers. RESULTS: A significant association was observed between exposure to maternal smoking in pregnancy and cigarette smoking in offspring ( p = .02). Exposed offspring were also more likely to have higher rates of major depression ( p = .04), bipolar disorder ( p = .04), and conduct disorder ( p = .04), and lower IQ ( p = .01), lower Global Assessment of Functioning (GAF) score ( p = .02), and more impaired Social Adjustment Inventory for Children and Adolescents (SAICA) scores versus unexposed offspring, adjusting for social class. CONCLUSION: Maternal smoking during pregnancy was found to increase the risk for smoking and a wide range of adverse psychiatric, cognitive, and functional outcomes in youth. FAU - Biederman, Joseph AU - Biederman J AD - 1 Massachusetts General Hospital, Boston, MA, USA. AD - 2 Harvard Medical School, Boston, MA, USA. FAU - Martelon, MaryKate AU - Martelon M AD - 1 Massachusetts General Hospital, Boston, MA, USA. FAU - Woodworth, K Yvonne AU - Woodworth KY AD - 1 Massachusetts General Hospital, Boston, MA, USA. FAU - Spencer, Thomas J AU - Spencer TJ AD - 1 Massachusetts General Hospital, Boston, MA, USA. AD - 2 Harvard Medical School, Boston, MA, USA. FAU - Faraone, Stephen V AU - Faraone SV AD - 3 State University of New York Upstate Medical University, Syracuse, NY, USA. LA - eng PT - Controlled Clinical Trial PT - Journal Article DEP - 20141121 PL - United States TA - J Atten Disord JT - Journal of attention disorders JID - 9615686 SB - IM MH - Adolescent MH - Attention Deficit Disorder with Hyperactivity/diagnosis/*epidemiology MH - Child MH - Cigarette Smoking/*adverse effects/epidemiology MH - Conduct Disorder/epidemiology MH - Depressive Disorder, Major/epidemiology MH - Female MH - Humans MH - Longitudinal Studies MH - Male MH - *Mothers MH - Pregnancy MH - *Prenatal Exposure Delayed Effects MH - Risk Factors MH - Social Class OTO - NOTNLM OT - ADHD OT - children OT - risk OT - smoking EDAT- 2014/11/25 06:00 MHDA- 2018/04/27 06:00 CRDT- 2014/11/23 06:00 PHST- 2014/11/25 06:00 [pubmed] PHST- 2018/04/27 06:00 [medline] PHST- 2014/11/23 06:00 [entrez] AID - 1087054714557357 [pii] AID - 10.1177/1087054714557357 [doi] PST - ppublish SO - J Atten Disord. 2017 Oct;21(12):975-985. doi: 10.1177/1087054714557357. Epub 2014 Nov 21.