PMID- 25416742
OWN - NLM
STAT- MEDLINE
DCOM- 20170110
LR  - 20181113
IS  - 1089-4098 (Electronic)
IS  - 1073-8584 (Print)
IS  - 1073-8584 (Linking)
VI  - 22
IP  - 1
DP  - 2016 Feb
TI  - Androgen Modulation of Hippocampal Structure and Function.
PG  - 46-60
LID - 10.1177/1073858414558065 [doi]
AB  - Androgens have profound effects on hippocampal structure and function, including 
      induction of spines and spine synapses on the dendrites of CA1 pyramidal neurons, 
      as well as alterations in long-term synaptic plasticity (LTP) and hippocampally 
      dependent cognitive behaviors. How these effects occur remains largely unknown. 
      Emerging evidence, however, suggests that one of the key elements in the response 
      mechanism may be modulation of brain-derived neurotrophic factor (BDNF) in the 
      mossy fiber (MF) system. In male rats, orchidectomy increases synaptic 
      transmission and excitability in the MF pathway. Testosterone reverses these 
      effects, suggesting that testosterone exerts tonic suppression on MF BDNF levels. 
      These findings suggest that changes in hippocampal function resulting from 
      declining androgen levels may reflect the outcome of responses mediated through 
      normally balanced, but opposing, mechanisms: loss of androgen effects on the 
      hippocampal circuitry may be compensated, at least in part, by an increase in 
      BDNF-dependent MF plasticity.
CI  - (c) The Author(s) 2014.
FAU - Atwi, Sarah
AU  - Atwi S
AD  - Department of Biomedical Sciences, Ontario Veterinary College, University of 
      Guelph, Guelph, Ontario, Canada.
FAU - McMahon, Dallan
AU  - McMahon D
AD  - Department of Biomedical Sciences, Ontario Veterinary College, University of 
      Guelph, Guelph, Ontario, Canada.
FAU - Scharfman, Helen
AU  - Scharfman H
AD  - The Nathan Kline Institute for Psychiatric Research, Orangeburg, NY, USA 
      Department of Child & Adolescent Psychiatry, Physiology & Neuroscience, and 
      Psychiatry, New York University Langone Medical Center, New York, NY, USA.
FAU - MacLusky, Neil J
AU  - MacLusky NJ
AD  - Department of Biomedical Sciences, Ontario Veterinary College, University of 
      Guelph, Guelph, Ontario, Canada nmaclusk@uoguelph.ca.
LA  - eng
GR  - R01 NS037562/NS/NINDS NIH HHS/United States
GR  - R56 NS037562/NS/NINDS NIH HHS/United States
GR  - NS-37562/NS/NINDS NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20141121
PL  - United States
TA  - Neuroscientist
JT  - The Neuroscientist : a review journal bringing neurobiology, neurology and 
      psychiatry
JID - 9504819
RN  - 0 (Androgens)
SB  - IM
MH  - Androgens/*metabolism
MH  - Animals
MH  - Hippocampus/*anatomy & histology/*physiology/physiopathology
MH  - Humans
PMC - PMC5002217
MID - NIHMS810436
OTO - NOTNLM
OT  - BDNF
OT  - CA3
OT  - hippocampus
OT  - mossy fibers
OT  - testosterone
EDAT- 2014/11/25 06:00
MHDA- 2017/01/11 06:00
PMCR- 2016/08/27
CRDT- 2014/11/23 06:00
PHST- 2014/11/23 06:00 [entrez]
PHST- 2014/11/25 06:00 [pubmed]
PHST- 2017/01/11 06:00 [medline]
PHST- 2016/08/27 00:00 [pmc-release]
AID - 1073858414558065 [pii]
AID - 10.1177/1073858414558065 [doi]
PST - ppublish
SO  - Neuroscientist. 2016 Feb;22(1):46-60. doi: 10.1177/1073858414558065. Epub 2014 
      Nov 21.