PMID- 25419515
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20201001
IS  - 2214-7500 (Print)
IS  - 2214-7500 (Electronic)
IS  - 2214-7500 (Linking)
VI  - 1
DP  - 2014
TI  - Neuronal reorganization in adult rats neonatally exposed to 
      (+/-)-3,4-methylenedioxymethamphetamine.
PG  - 699-706
AB  - The abuse of methylenedioxymethamphetamine (MDMA) during pregnancy is of concern. 
      MDMA treatment of rats during a period of brain growth analogous to late human 
      gestation leads to neurochemical and behavioral changes. MDMA from postnatal day 
      (P)11-20 in rats produces reductions in serotonin and deficits in spatial and 
      route-based navigation. In this experiment we examined the impact of MDMA from 
      P11-20 (20 mg/kg twice daily, 8 h apart) on neuronal architecture. Golgi 
      impregnated sections showed significant changes. In the nucleus accumbens, the 
      dendrites were shorter with fewer spines, whereas in the dentate gyrus the 
      dendritic length was decreased but with more spines, and for the entorhinal 
      cortex, reductions in basilar and apical dendritic lengths in MDMA animals 
      compared with saline animals were seen. The data show that neuronal 
      cytoarchitectural changes are long-lasting following developmental MDMA exposure 
      and are in regions consistent with the learning and memory deficits observed in 
      such animals.
FAU - Williams, Michael T
AU  - Williams MT
AD  - Division of Neurology, Cincinnati Children's Research Foundation and University 
      of Cincinnati College of Medicine, Cincinnati, OH 45229.
FAU - Skelton, Matthew R
AU  - Skelton MR
AD  - Division of Neurology, Cincinnati Children's Research Foundation and University 
      of Cincinnati College of Medicine, Cincinnati, OH 45229.
FAU - Longacre, Ian D
AU  - Longacre ID
AD  - East Tennessee State University, Department of Psychology, Johnson City, TN.
FAU - Huggins, Kimberly N
AU  - Huggins KN
AD  - East Tennessee State University, Department of Psychology, Johnson City, TN.
FAU - Maple, Amanda M
AU  - Maple AM
AD  - East Tennessee State University, Department of Psychology, Johnson City, TN.
FAU - Vorhees, Charles V
AU  - Vorhees CV
AD  - Division of Neurology, Cincinnati Children's Research Foundation and University 
      of Cincinnati College of Medicine, Cincinnati, OH 45229.
FAU - Brown, Russell W
AU  - Brown RW
AD  - East Tennessee State University, Department of Psychology, Johnson City, TN.
LA  - eng
GR  - K01 DA014269/DA/NIDA NIH HHS/United States
GR  - R01 DA021394/DA/NIDA NIH HHS/United States
GR  - UL1 TR001425/TR/NCATS NIH HHS/United States
PT  - Journal Article
PL  - Ireland
TA  - Toxicol Rep
JT  - Toxicology reports
JID - 101630272
PMC - PMC4235131
MID - NIHMS626247
OTO - NOTNLM
OT  - Golgi-Cox staining
OT  - dentate gyrus
OT  - development
OT  - entorhinal cortex
EDAT- 2014/11/25 06:00
MHDA- 2014/11/25 06:01
PMCR- 2014/09/06
CRDT- 2014/11/25 06:00
PHST- 2014/11/25 06:00 [entrez]
PHST- 2014/11/25 06:00 [pubmed]
PHST- 2014/11/25 06:01 [medline]
PHST- 2014/09/06 00:00 [pmc-release]
AID - S2214-7500(14)00081-X [pii]
AID - 10.1016/j.toxrep.2014.08.018 [doi]
PST - ppublish
SO  - Toxicol Rep. 2014;1:699-706. doi: 10.1016/j.toxrep.2014.08.018.