PMID- 25421372
OWN - NLM
STAT- MEDLINE
DCOM- 20160104
LR  - 20220409
IS  - 1759-5037 (Electronic)
IS  - 1759-5029 (Linking)
VI  - 11
IP  - 2
DP  - 2015 Feb
TI  - Gastric emptying and glycaemia in health and diabetes mellitus.
PG  - 112-28
LID - 10.1038/nrendo.2014.202 [doi]
AB  - The rate of gastric emptying is a critical determinant of postprandial glycaemia 
      and, accordingly, is fundamental to maintaining blood glucose homeostasis. 
      Disordered gastric emptying occurs frequently in patients with longstanding type 
      1 diabetes mellitus and type 2 diabetes mellitus (T2DM). A complex bidirectional 
      relationship exists between gastric emptying and glycaemia--gastric emptying 
      accounts for  approximately 35% of the variance in peak postprandial blood glucose 
      concentrations in healthy individuals and in patients with diabetes mellitus, and 
      the rate of emptying is itself modulated by acute changes in glycaemia. Clinical 
      implementation of incretin-based therapies for the management of T2DM, which 
      diminish postprandial glycaemia, in part by slowing gastric emptying, is 
      widespread. Other therapies for patients with T2DM, which specifically target 
      gastric emptying include pramlintide and dietary-based treatment approaches. A 
      weak association exists between upper gastrointestinal symptoms and the rate of 
      gastric emptying. In patients with severe diabetic gastroparesis, pathological 
      changes are highly variable and are characterized by loss of interstitial cells 
      of Cajal and an immune infiltrate. Management options for patients with 
      symptomatic gastroparesis remain limited in their efficacy, which probably 
      reflects the heterogeneous nature of the underlying pathophysiology.
FAU - Phillips, Liza K
AU  - Phillips LK
AD  - Centre of Research Excellence in Translating Nutritional Science to Good Health, 
      Discipline of Medicine, The University of Adelaide, Level 6 Eleanor Harrald 
      Building, Royal Adelaide Hospital, Frome Road, Adelaide, SA 5005, Australia.
FAU - Deane, Adam M
AU  - Deane AM
AD  - Centre of Research Excellence in Translating Nutritional Science to Good Health, 
      Discipline of Medicine, The University of Adelaide, Level 6 Eleanor Harrald 
      Building, Royal Adelaide Hospital, Frome Road, Adelaide, SA 5005, Australia.
FAU - Jones, Karen L
AU  - Jones KL
AD  - Centre of Research Excellence in Translating Nutritional Science to Good Health, 
      Discipline of Medicine, The University of Adelaide, Level 6 Eleanor Harrald 
      Building, Royal Adelaide Hospital, Frome Road, Adelaide, SA 5005, Australia.
FAU - Rayner, Chris K
AU  - Rayner CK
AD  - Centre of Research Excellence in Translating Nutritional Science to Good Health, 
      Discipline of Medicine, The University of Adelaide, Level 6 Eleanor Harrald 
      Building, Royal Adelaide Hospital, Frome Road, Adelaide, SA 5005, Australia.
FAU - Horowitz, Michael
AU  - Horowitz M
AD  - Centre of Research Excellence in Translating Nutritional Science to Good Health, 
      Discipline of Medicine, The University of Adelaide, Level 6 Eleanor Harrald 
      Building, Royal Adelaide Hospital, Frome Road, Adelaide, SA 5005, Australia.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20141125
PL  - England
TA  - Nat Rev Endocrinol
JT  - Nature reviews. Endocrinology
JID - 101500078
RN  - 0 (Hypoglycemic Agents)
SB  - IM
MH  - Gastric Emptying/drug effects/*physiology
MH  - Humans
MH  - Hyperglycemia/drug therapy
MH  - Hypoglycemic Agents/therapeutic use
MH  - Postprandial Period
EDAT- 2014/11/26 06:00
MHDA- 2016/01/05 06:00
CRDT- 2014/11/26 06:00
PHST- 2014/11/26 06:00 [entrez]
PHST- 2014/11/26 06:00 [pubmed]
PHST- 2016/01/05 06:00 [medline]
AID - nrendo.2014.202 [pii]
AID - 10.1038/nrendo.2014.202 [doi]
PST - ppublish
SO  - Nat Rev Endocrinol. 2015 Feb;11(2):112-28. doi: 10.1038/nrendo.2014.202. Epub 
      2014 Nov 25.