PMID- 25422737
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20141125
LR  - 20200930
IS  - 2008-384X (Print)
IS  - 2252-0058 (Electronic)
IS  - 2008-384X (Linking)
VI  - 13
IP  - 3
DP  - 2014 Jul 4
TI  - Association of interleukin 7 receptor gene polymorphism rs6897932 with multiple 
      sclerosis patients in Khuzestan.
PG  - 168-71
AB  - BACKGROUND: Multiple sclerosis (MS) is a chronic inflammatory demyelinating and 
      neurodegenerative disease of central nervous system with unknown causes. Etiology 
      of MS involves both genetic and environment factors. The interleukin 7 receptor 
      (IL7R) gene is a promising candidate for MS, because its involvement in the 
      autoimmunity, regulation of the T-cell homeostasis, proliferation, and 
      anti-apoptotic signaling. METHODS: We investigated the association of the IL7R 
      gene polymorphism rs6897932 in MS patients in a case and control study. In this 
      case and control study participating, 127 relapsing-remitting MS (RRMS) patients 
      (mean age: 32.25, age range: 16-57) selected according McDonald criteria, and 109 
      ethnically, sex and age matched healthy control (mean age: 27.44, age range: 
      14-63) with no personal or family history of autoimmune diseases were studied. 
      DNA was extracted from whole blood using high pure polymerase chain reaction 
      template preparation kit from Roch Company. Amplification refractory mutation 
      system method was applied to define the genotyping C/T within exon 6 of the IL7R 
      gene among individuals. RESULTS: Evaluation of the IL7R gene polymorphism 
      revealed that the T allele and the C/T and T/T genotypes are present in 53.5%, 
      42.5%, 4.0%, and 68.8%, 26.6%, 4.6% in MS patients and controls, respectively. 
      Comparison between alleles and genotypes in the MS patients and healthy controls 
      show significant differences (P = 0.038). CONCLUSION: The distribution of the 
      rs6897932 polymorphism is significantly different in our case/control study in 
      Khuzestan Province. This single nucleotide polymorphism causes alternative 
      splicing in exon 6 of the IL7R gene with possible influence of the autoimmunity.
FAU - Majdinasab, Nastaran
AU  - Majdinasab N
AD  - Musculoskeletal Rehabilitation Research Center AND Department of Neurology, 
      School of Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, 
      Iran.
FAU - Hosseini Behbahani, Mahshid
AU  - Hosseini Behbahani M
AD  - Department of Biochemistry, Payame Noor University, Tehran, Iran.
FAU - Galehdari, Hamid
AU  - Galehdari H
AD  - Departmanet of Genetic, School of Sciences, Shahid Chamran University, Ahvaz, 
      Iran.
FAU - Mohaghegh, Maryam
AU  - Mohaghegh M
AD  - Departmanet of Genetic, School of Sciences, Shahid Chamran University, Ahvaz, 
      Iran.
LA  - eng
PT  - Journal Article
PL  - Iran
TA  - Iran J Neurol
JT  - Iranian journal of neurology
JID - 101589458
PMC - PMC4240935
OTO - NOTNLM
OT  - Amplified Refractory Mutation System
OT  - Interleukin 7 Receptor
OT  - Multiple Sclerosis
OT  - Polymorphism
OT  - Relapsing-Remitting Multiple Sclerosis
EDAT- 2014/11/26 06:00
MHDA- 2014/11/26 06:01
PMCR- 2014/07/04
CRDT- 2014/11/26 06:00
PHST- 2014/05/17 00:00 [received]
PHST- 2014/04/19 00:00 [accepted]
PHST- 2014/11/26 06:00 [entrez]
PHST- 2014/11/26 06:00 [pubmed]
PHST- 2014/11/26 06:01 [medline]
PHST- 2014/07/04 00:00 [pmc-release]
AID - IJNL-13-168 [pii]
PST - ppublish
SO  - Iran J Neurol. 2014 Jul 4;13(3):168-71.