PMID- 25422957
OWN - NLM
STAT- MEDLINE
DCOM- 20150803
LR  - 20221207
IS  - 1469-2198 (Electronic)
IS  - 0954-5794 (Print)
IS  - 0954-5794 (Linking)
VI  - 26
IP  - 4 Pt 2
DP  - 2014 Nov
TI  - Genetic moderation of child maltreatment effects on depression and internalizing 
      symptoms by serotonin transporter linked polymorphic region (5-HTTLPR), 
      brain-derived neurotrophic factor (BDNF), norepinephrine transporter (NET), and 
      corticotropin releasing hormone receptor 1 (CRHR1) genes in African American 
      children.
PG  - 1219-39
LID - 10.1017/S0954579414000984 [doi]
AB  - Genetic moderation of the effects of child maltreatment on depression and 
      internalizing symptoms was investigated in a sample of low-income maltreated and 
      nonmaltreated African American children (N = 1,096). Lifetime child maltreatment 
      experiences were independently coded from Child Protective Services records and 
      maternal report. Child depression and internalizing problems were assessed in the 
      context of a summer research camp by self-report on the Children's Depression 
      Inventory and adult counselor report on the Teacher Report Form. DNA was obtained 
      from buccal cell or saliva samples and genotyped for polymorphisms of the 
      following genes: serotonin transporter linked polymorphic region (5-HTTLPR), 
      brain-derived neurotrophic factor (BDNF), norepinephrine transporter, and 
      corticotropin releasing hormone receptor 1. Analyses of covariance with age and 
      gender as covariates were conducted, with maltreatment status and respective 
      polymorphism as main effects and their Gene x Environment (G x E) interactions. 
      Maltreatment consistently was associated with higher Children's Depression 
      Inventory and Teacher Report Form symptoms. The results for child self-report 
      symptoms indicated a G x E interaction for BDNF and maltreatment. In addition, 
      BDNF and triallelic 5-HTTLPR interacted with child maltreatment in a G x G x E 
      interaction. Analyses for counselor report of child anxiety/depression symptoms 
      on the Teacher Report Form indicated moderation of child maltreatment effects by 
      triallelic 5-HTTLPR. These effects were elaborated based on variation in 
      developmental timing of maltreatment experiences. Norepinephrine transporter was 
      found to further moderate the G x E interaction of 5-HTTLPR and maltreatment 
      status, revealing a G x G x E interaction. This G x G x E was extended by 
      consideration of variation in maltreatment subtype experiences. Finally, G x G x 
      E effects were observed for the co-action of BDNF and the corticotropin releasing 
      hormone receptor 1 haplotype. The findings illustrate the variable influence of 
      specific genotypes in G x E interactions based on variation in maltreatment 
      experiences and the importance of a multigenic approach for understanding 
      influences on depression and internalizing symptoms among African American 
      children.
FAU - Cicchetti, Dante
AU  - Cicchetti D
AD  - University of Minnesota Institute of Child Development.
FAU - Rogosch, Fred A
AU  - Rogosch FA
AD  - University of Rochester Mt. Hope Family Center.
LA  - eng
GR  - R01 DA017741/DA/NIDA NIH HHS/United States
GR  - R01 MH083979/MH/NIMH NIH HHS/United States
PT  - Journal Article
PL  - United States
TA  - Dev Psychopathol
JT  - Development and psychopathology
JID - 8910645
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Norepinephrine Plasma Membrane Transport Proteins)
RN  - 0 (Receptors, Corticotropin-Releasing Hormone)
RN  - 0 (SLC6A2 protein, human)
RN  - 0 (SLC6A4 protein, human)
RN  - 0 (Serotonin Plasma Membrane Transport Proteins)
RN  - 5CLY6W2H1M (CRF receptor type 1)
SB  - IM
MH  - Black or African American/*genetics/psychology
MH  - Anxiety/genetics/psychology
MH  - Brain-Derived Neurotrophic Factor/*genetics
MH  - Child
MH  - Child Abuse/*psychology
MH  - Depression/*genetics/psychology
MH  - Female
MH  - *Gene-Environment Interaction
MH  - Humans
MH  - Male
MH  - Norepinephrine Plasma Membrane Transport Proteins/genetics
MH  - Poverty
MH  - Receptors, Corticotropin-Releasing Hormone/genetics
MH  - Serotonin Plasma Membrane Transport Proteins/*genetics
PMC - PMC4244663
MID - NIHMS620577
EDAT- 2014/11/26 06:00
MHDA- 2015/08/04 06:00
PMCR- 2015/11/01
CRDT- 2014/11/26 06:00
PHST- 2014/11/26 06:00 [entrez]
PHST- 2014/11/26 06:00 [pubmed]
PHST- 2015/08/04 06:00 [medline]
PHST- 2015/11/01 00:00 [pmc-release]
AID - S0954579414000984 [pii]
AID - 10.1017/S0954579414000984 [doi]
PST - ppublish
SO  - Dev Psychopathol. 2014 Nov;26(4 Pt 2):1219-39. doi: 10.1017/S0954579414000984.