PMID- 25422959
OWN - NLM
STAT- MEDLINE
DCOM- 20150803
LR  - 20220129
IS  - 1469-2198 (Electronic)
IS  - 0954-5794 (Linking)
VI  - 26
IP  - 4 Pt 2
DP  - 2014 Nov
TI  - Maternal prenatal anxiety and child brain-derived neurotrophic factor (BDNF) 
      genotype: effects on internalizing symptoms from 4 to 15 years of age.
PG  - 1255-66
LID - 10.1017/S095457941400100X [doi]
AB  - Multiple behavioral and health outcomes, including internalizing symptoms, may be 
      predicted from prenatal maternal anxiety, depression, or stress. However, not all 
      children are affected, and those that are can be affected in different ways. Here 
      we test the hypothesis that the effects of prenatal anxiety are moderated by 
      genetic variation in the child's brain-derived neurotrophic factor (BDNF) gene, 
      using the Avon Longitudinal Study of Parents and Children population cohort. 
      Internalizing symptoms were assessed from 4 to 13 years of age using the 
      Strengths and Difficulties Questionnaire (n = 8,584); a clinical interview with 
      the adolescents was conducted at age 15 years (n = 4,704). Obstetric and 
      psychosocial risk and postnatal maternal symptoms were included as covariates. 
      Results show that prenatal maternal anxiety predicted internalizing symptoms, 
      including with the diagnostic assessment at 15 years. There was a main effect of 
      two BDNF polymorphisms (rs6265 [val66met] and rs11030104) on internalizing 
      symptoms up to age 13. There was also genetic moderation of the prenatal anxiety 
      effect by different BDNF polymorphisms (rs11030121 and rs7124442), although 
      significant effects were limited to preadolescence. The findings suggest a role 
      for BDNF gene-environment interactions in individual vulnerability to the effects 
      of prenatal anxiety on child internalizing symptoms.
FAU - O'Donnell, Kieran J
AU  - O'Donnell KJ
AD  - McGill University.
FAU - Glover, Vivette
AU  - Glover V
AD  - Imperial College London.
FAU - Holbrook, Joanna D
AU  - Holbrook JD
AD  - Singapore Institute for Clinical Sciences.
FAU - O'Connor, Thomas G
AU  - O'Connor TG
AD  - University of Rochester Medical Center.
LA  - eng
GR  - 102215/WT_/Wellcome Trust/United Kingdom
GR  - MC_PC_15018/MRC_/Medical Research Council/United Kingdom
GR  - R01 MH073842/MH/NIMH NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Dev Psychopathol
JT  - Development and psychopathology
JID - 8910645
RN  - 0 (Brain-Derived Neurotrophic Factor)
SB  - IM
MH  - Adolescent
MH  - Anxiety/*epidemiology
MH  - *Behavioral Symptoms/epidemiology/etiology/genetics
MH  - Brain-Derived Neurotrophic Factor/*genetics
MH  - Child
MH  - Child, Preschool
MH  - England/epidemiology
MH  - Female
MH  - *Gene-Environment Interaction
MH  - Genotype
MH  - Humans
MH  - Longitudinal Studies
MH  - Pregnancy
MH  - Pregnancy Complications/*epidemiology
EDAT- 2014/11/26 06:00
MHDA- 2015/08/04 06:00
CRDT- 2014/11/26 06:00
PHST- 2014/11/26 06:00 [entrez]
PHST- 2014/11/26 06:00 [pubmed]
PHST- 2015/08/04 06:00 [medline]
AID - S095457941400100X [pii]
AID - 10.1017/S095457941400100X [doi]
PST - ppublish
SO  - Dev Psychopathol. 2014 Nov;26(4 Pt 2):1255-66. doi: 10.1017/S095457941400100X.