PMID- 25423015
OWN - NLM
STAT- MEDLINE
DCOM- 20151001
LR  - 20181113
IS  - 1557-8518 (Electronic)
IS  - 1540-4196 (Print)
IS  - 1540-4196 (Linking)
VI  - 13
IP  - 1
DP  - 2015 Feb
TI  - Obese first-degree relatives of patients with type 2 diabetes with elevated 
      triglyceride levels exhibit increased beta-cell function.
PG  - 45-51
LID - 10.1089/met.2014.0095 [doi]
AB  - BACKGROUND: Type 2 diabetes mellitus (T2DM) is characterized as a disease 
      continuum that is marked by metabolic changes that are present for several years, 
      sometimes well before frank diagnosis of T2DM. Genetic predisposition, ethnicity, 
      geography, alterations in BMI, and lipid profile are considered important markers 
      for the pathogenesis of T2DM through mechanisms that remain unresolved and 
      controversial. The aim of this study was to investigate the relationship between 
      triglycerides (TGs) and beta-cell function, insulin resistance (IR), and insulin 
      sensitivity (IS) in obese first-degree relatives of patients with T2DM (FDR-T2DM) 
      among subjects from central Mexico with normal glucose tolerance (NGT). METHODS: 
      We studied 372 FDR-T2DM subjects (ages,18-65) and determined body mass index 
      (BMI), fasting plasma glucose (FPG), oral glucose tolerance test (OGTT), insulin, 
      and TGs levels. Subjects were categorized based on glycemic control [NGT, 
      prediabetes (PT2DM), or T2DM]. NGT subjects were further categorized by BMI 
      [normal weight (Ob-) or obese (Ob+)] and TGs levels (TG-, <150 mg/dL, or TG+, 
      >/=150 mg/dL). beta-cell function, IR, and IS were determined by the homeostasis model 
      assessment of beta-cell function (HOMA2-beta), homeostasis model assessment of insulin 
      resistance (HOMA2-IR), and Quantitative Insulin Sensitivity Check Index (QUICKI) 
      indices, respectively. RESULTS: The obese subjects with elevated TGs levels had 
      21%-60% increased beta-cell function when compared to all groups (P<0.05). In 
      addition, this group had insulin levels, IS, and IR similar to PT2DM. 
      Furthermore, only in obese subjects did TGs correlate with beta-cell function 
      (rho=0.502, P<0.001). CONCLUSION: We characterized FDR-T2DM subjects from central 
      Mexico with NGT and revealed a class of obese subjects with elevated TGs and 
      beta-cell function, which may precede PT2DM.
FAU - Torres-Rasgado, Enrique
AU  - Torres-Rasgado E
AD  - 1 Facultad de Medicina, Benemerita Universidad Autonoma de Puebla , Puebla, 
      Puebla, Mexico.
FAU - Porchia, Leonardo M
AU  - Porchia LM
FAU - Ruiz-Vivanco, Guadalupe
AU  - Ruiz-Vivanco G
FAU - Gonzalez-Mejia, M Elba
AU  - Gonzalez-Mejia ME
FAU - Baez-Duarte, Blanca G
AU  - Baez-Duarte BG
FAU - Pulido-Perez, Patricia
AU  - Pulido-Perez P
FAU - Rivera, Alicia
AU  - Rivera A
FAU - Romero, Jose R
AU  - Romero JR
FAU - Perez-Fuentes, Ricardo
AU  - Perez-Fuentes R
LA  - eng
GR  - R01 HL096518/HL/NHLBI NIH HHS/United States
GR  - R01 HL-096518/HL/NHLBI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20141125
PL  - United States
TA  - Metab Syndr Relat Disord
JT  - Metabolic syndrome and related disorders
JID - 101150318
RN  - 0 (Triglycerides)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Body Mass Index
MH  - Cross-Sectional Studies
MH  - *Diabetes Mellitus, Type 2/epidemiology
MH  - *Family
MH  - *Family Health/statistics & numerical data
MH  - Female
MH  - Humans
MH  - Insulin-Secreting Cells/*physiology
MH  - Male
MH  - Mexico/epidemiology
MH  - Middle Aged
MH  - Obesity/*blood/epidemiology/*physiopathology
MH  - Prediabetic State/physiopathology
MH  - Triglycerides/*blood
MH  - Young Adult
PMC - PMC4361158
EDAT- 2014/11/26 06:00
MHDA- 2015/10/02 06:00
PMCR- 2016/02/01
CRDT- 2014/11/26 06:00
PHST- 2014/11/26 06:00 [entrez]
PHST- 2014/11/26 06:00 [pubmed]
PHST- 2015/10/02 06:00 [medline]
PHST- 2016/02/01 00:00 [pmc-release]
AID - 10.1089/met.2014.0095 [pii]
AID - 10.1089/met.2014.0095 [doi]
PST - ppublish
SO  - Metab Syndr Relat Disord. 2015 Feb;13(1):45-51. doi: 10.1089/met.2014.0095. Epub 
      2014 Nov 25.