PMID- 25423614
OWN - NLM
STAT- MEDLINE
DCOM- 20151110
LR  - 20150105
IS  - 1543-8392 (Electronic)
IS  - 1543-8384 (Linking)
VI  - 12
IP  - 1
DP  - 2015 Jan 5
TI  - Roughness-controlled self-assembly of mannitol/LB agar microparticles by 
      polymorphic transformation for pulmonary drug delivery.
PG  - 223-31
LID - 10.1021/mp5005614 [doi]
AB  - Novel roughness-controlled mannitol/LB Agar microparticles were synthesized by 
      polymorphic transformation and self-assembly method using hexane as the 
      polymorphic transformation reagent and spray-dried mannitol/LB Agar 
      microparticles as the starting material. As-prepared microparticles were 
      characterized by Fourier transform infrared spectra (FTIR), X-ray diffraction 
      spectra (XRD), differential scanning calorimetry (DSC), scanning electron 
      microscopy (SEM), thermal gravimetric analysis (TGA), and Andersen Cascade 
      Impactor (ACI). The XRD and DSC results indicate that after immersing spray-dried 
      mannitol/LB Agar microparticles in hexane, beta-mannitol was completely transformed 
      to alpha-mannitol in 1 h, and all the delta-mannitol was transformed to alpha form after 14 
      days. SEM shows that during the transformation the nanobelts on the spray-dried 
      mannitol/LB Agar microparticles become more dispersed and the contour of the 
      individual nanobelts becomes more noticeable. Afterward, the nanobelts 
      self-assemble to nanorods and result in rod-covered mannitol/LB Agar 
      microparticles. FTIR indicates new hydrogen bonds were formed among mannitol, LB 
      Agar, and hexane. SEM images coupled with image analysis software reveal that 
      different surface morphology of the microparticles have different drug adhesion 
      mechanisms. Comparison of ACI results and image analysis of SEM images shows that 
      an increase in the particle surface roughness can increase the fine particle 
      fractions (FPFs) using the rod-covered mannitol microparticles as drug carriers. 
      Transformed microparticles show higher FPFs than commercially available lactose 
      carriers. An FPF of 28.6 +/- 2.4% was achieved by microparticles transformed from 
      spray-dried microparticles using 2% mannitol(w/v)/LB Agar as feed solution. It is 
      comparable to the highest FPF reported in the literature using lactose and 
      spray-dried mannitol as carriers.
FAU - Zhang, Fengying
AU  - Zhang F
AD  - School of Chemical and Biomedical Engineering, Nanyang Technological University , 
      62 Nanyang Drive, Singapore 637459, Singapore.
FAU - Ngoc, Nguyen Thi Quynh
AU  - Ngoc NT
FAU - Tay, Bao Hui
AU  - Tay BH
FAU - Mendyk, Aleksander
AU  - Mendyk A
FAU - Shao, Yu-Hsuan
AU  - Shao YH
FAU - Lau, Raymond
AU  - Lau R
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20141210
PL  - United States
TA  - Mol Pharm
JT  - Molecular pharmaceutics
JID - 101197791
RN  - 0 (Drug Carriers)
RN  - 0 (Powders)
RN  - 3OWL53L36A (Mannitol)
RN  - 9002-18-0 (Agar)
RN  - J2B2A4N98G (Lactose)
SB  - IM
MH  - Agar/*chemistry
MH  - Calorimetry, Differential Scanning
MH  - Crystallography, X-Ray
MH  - Drug Carriers/chemistry
MH  - *Drug Delivery Systems
MH  - Hydrogen Bonding
MH  - Lactose/chemistry
MH  - Lung/*drug effects
MH  - Mannitol/*chemistry
MH  - Materials Testing
MH  - Microscopy, Electron, Scanning
MH  - Microspheres
MH  - Particle Size
MH  - Powders
MH  - Spectroscopy, Fourier Transform Infrared
MH  - Surface Properties
MH  - Thermogravimetry
MH  - X-Ray Diffraction
OTO - NOTNLM
OT  - image analysis
OT  - mannitol
OT  - polymorphic transformation
OT  - pulmonary delivery
OT  - self-assembly
OT  - surface morphology
EDAT- 2014/11/26 06:00
MHDA- 2015/11/11 06:00
CRDT- 2014/11/26 06:00
PHST- 2014/11/26 06:00 [entrez]
PHST- 2014/11/26 06:00 [pubmed]
PHST- 2015/11/11 06:00 [medline]
AID - 10.1021/mp5005614 [doi]
PST - ppublish
SO  - Mol Pharm. 2015 Jan 5;12(1):223-31. doi: 10.1021/mp5005614. Epub 2014 Dec 10.