PMID- 25424047
OWN - NLM
STAT- MEDLINE
DCOM- 20160218
LR  - 20181202
IS  - 1471-1753 (Electronic)
IS  - 0954-6634 (Linking)
VI  - 26
IP  - 4
DP  - 2015
TI  - Efficacy of the apitherapy in the treatment of recalcitrant localized plaque 
      psoriasis and evaluation of tumor necrosis factor-alpha (TNF-alpha) serum level: A 
      double-blind randomized clinical trial.
PG  - 335-9
LID - 10.3109/09546634.2014.990411 [doi]
AB  - BACKGROUND: No universal consensus about optimal modality for treating the 
      recalcitrant localized plaque psoriasis (RLPP) is available. OBJECTIVE: To 
      evaluate the immunological and clinical therapeutic effect of using apitherapy in 
      the treatment of RLPP. METHODS: Randomized 50 patients with RLPP received 
      apitherapy (n = 25) and placebo (n = 25) every week. Both treatments were 
      injected into lesions at weekly intervals for a maximum of 12 treatments. 
      Following up was 6 months later. Tumor necrosis factor-alpha (TNF-alpha) level was 
      measured at pre-study and at 12th week. RESULTS: A significant difference was 
      found between the therapeutic responses of RLPP to the apitherapy and placebo 
      groups (p<0.001). In the apitherapy group, complete response was achieved in 92% 
      of patients. There was statistically significant decrease in TNF-alpha in the 
      apitherapy group compared to the placebo group. No recurrence was observed in the 
      apitherapy group. CONCLUSION: Apitherapy is effective and a safe treatment for 
      recalcitrant localized plaque psoriasis, when other topical or physical therapies 
      have failed.
FAU - Eltaher, Soha
AU  - Eltaher S
AD  - Department of Dermatology and Venereology, Faculty of Medicine, Suez Canal 
      University , Ismailia , Egypt and.
FAU - Mohammed, Ghada F
AU  - Mohammed GF
FAU - Younes, Soha
AU  - Younes S
FAU - Elakhras, Atef
AU  - Elakhras A
LA  - eng
PT  - Journal Article
PT  - Randomized Controlled Trial
DEP - 20141230
PL  - England
TA  - J Dermatolog Treat
JT  - The Journal of dermatological treatment
JID - 8918133
RN  - 0 (Tumor Necrosis Factor-alpha)
SB  - IM
MH  - Adult
MH  - Apitherapy/*methods
MH  - Double-Blind Method
MH  - Female
MH  - Humans
MH  - Male
MH  - Psoriasis/*therapy
MH  - Remission Induction
MH  - Tumor Necrosis Factor-alpha/*blood
MH  - Young Adult
OTO - NOTNLM
OT  - Apitherapy
OT  - PGA
OT  - TNF-alpha
OT  - bee venom
OT  - recalcitrant localized plaque psoriasis
EDAT- 2014/11/27 06:00
MHDA- 2016/02/19 06:00
CRDT- 2014/11/27 06:00
PHST- 2014/11/27 06:00 [entrez]
PHST- 2014/11/27 06:00 [pubmed]
PHST- 2016/02/19 06:00 [medline]
AID - 10.3109/09546634.2014.990411 [doi]
PST - ppublish
SO  - J Dermatolog Treat. 2015;26(4):335-9. doi: 10.3109/09546634.2014.990411. Epub 
      2014 Dec 30.