PMID- 25424368
OWN - NLM
STAT- MEDLINE
DCOM- 20150824
LR  - 20181113
IS  - 1414-431X (Electronic)
IS  - 0100-879X (Print)
IS  - 0100-879X (Linking)
VI  - 48
IP  - 2
DP  - 2015 Feb
TI  - Role of chemokines in promoting instability of coronary atherosclerotic plaques 
      and the underlying molecular mechanism.
PG  - 161-6
LID - S0100-879X2014005044195 [pii]
LID - 10.1590/1414-431X20144195 [doi]
AB  - Our aim was to investigate the role of chemokines in promoting instability of 
      coronary atherosclerotic plaques and the underlying molecular mechanism. Coronary 
      angiography and intravascular ultrasound (IVUS) were performed in 60 stable 
      angina pectoris (SAP) patients and 60 unstable angina pectoris (UAP) patients. 
      The chemotactic activity of monocytes in the 2 groups of patients was examined in 
      Transwell chambers. High-sensitivity C-reactive protein (hs-CRP), monocyte 
      chemoattractant protein-1 (MCP-1), regulated on activation in normal T-cell 
      expressed and secreted (RANTES), and fractalkine in serum were examined with 
      ELISA kits, and expression of MCP-1, RANTES, and fractalkine mRNA was examined 
      with real-time PCR. In the SAP group, 92 plaques were detected with IVUS. In the 
      UAP group, 96 plaques were detected with IVUS. The plaques in the UAP group were 
      mainly lipid 51.04% (49/96) and the plaques in the SAP group were mainly fibrous 
      52.17% (48/92). Compared with the SAP group, the plaque burden and vascular 
      remodeling index in the UAP group were significantly greater than in the SAP 
      group (P<0.01). Chemotactic activity and the number of mobile monocytes in the 
      UAP group were significantly greater than in the SAP group (P<0.01). 
      Concentrations of hs-CRP, MCP-1, RANTES, and fractalkine in the serum of the UAP 
      group were significantly higher than in the serum of the SAP group (P<0.05 or 
      P<0.01), and expression of MCP-1, RANTES, and fractalkine mRNA was significantly 
      higher than in the SAP group (P<0.05). MCP-1, RANTES, and fractalkine probably 
      promote instability of coronary atherosclerotic plaque.
FAU - Zhong, Z X
AU  - Zhong ZX
AD  - Department of Cardiology, Meizhou Hospital Affiliated to Zhongshan University, 
      Meizhou, Guangdong, China.
FAU - Li, B
AU  - Li B
AD  - Department of Cardiology, Meizhou Hospital Affiliated to Zhongshan University, 
      Meizhou, Guangdong, China.
FAU - Li, C R
AU  - Li CR
AD  - Department of Cardiology, Meizhou Hospital Affiliated to Zhongshan University, 
      Meizhou, Guangdong, China.
FAU - Zhang, Q F
AU  - Zhang QF
AD  - Department of Cardiology, Meizhou Hospital Affiliated to Zhongshan University, 
      Meizhou, Guangdong, China.
FAU - Liu, Z D
AU  - Liu ZD
AD  - Department of Cardiology, Meizhou Hospital Affiliated to Zhongshan University, 
      Meizhou, Guangdong, China.
FAU - Zhang, P F
AU  - Zhang PF
AD  - Department of Cardiology, Meizhou Hospital Affiliated to Zhongshan University, 
      Meizhou, Guangdong, China.
FAU - Gu, X F
AU  - Gu XF
AD  - Department of Cardiology, Meizhou Hospital Affiliated to Zhongshan University, 
      Meizhou, Guangdong, China.
FAU - Luo, H
AU  - Luo H
AD  - Department of Cardiology, Meizhou Hospital Affiliated to Zhongshan University, 
      Meizhou, Guangdong, China.
FAU - Li, M J
AU  - Li MJ
AD  - Department of Cardiology, Meizhou Hospital Affiliated to Zhongshan University, 
      Meizhou, Guangdong, China.
FAU - Luo, H S
AU  - Luo HS
AD  - Department of Cardiology, Meizhou Hospital Affiliated to Zhongshan University, 
      Meizhou, Guangdong, China.
FAU - Ye, G H
AU  - Ye GH
AD  - Department of Cardiology, Meizhou Hospital Affiliated to Zhongshan University, 
      Meizhou, Guangdong, China.
FAU - Wen, F L
AU  - Wen FL
AD  - Department of Cardiology, Meizhou Hospital Affiliated to Zhongshan University, 
      Meizhou, Guangdong, China.
LA  - eng
PT  - Journal Article
DEP - 20141121
PL  - Brazil
TA  - Braz J Med Biol Res
JT  - Brazilian journal of medical and biological research = Revista brasileira de 
      pesquisas medicas e biologicas
JID - 8112917
RN  - 0 (Chemokine CCL2)
RN  - 0 (Chemokine CCL5)
RN  - 0 (Chemokine CX3CL1)
RN  - 0 (Chemokines)
RN  - 9007-41-4 (C-Reactive Protein)
SB  - IM
MH  - Adult
MH  - Angina Pectoris/*metabolism/physiopathology
MH  - C-Reactive Protein/analysis
MH  - Chemokine CCL2/blood
MH  - Chemokine CCL5/blood
MH  - Chemokine CX3CL1/blood
MH  - Chemokines/*metabolism
MH  - Chemotaxis/*physiology
MH  - Coronary Artery Disease/*metabolism/physiopathology
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Monocytes/*metabolism
MH  - Plaque, Atherosclerotic/*physiopathology
MH  - Real-Time Polymerase Chain Reaction
MH  - Ultrasonography, Interventional
PMC - PMC4321222
EDAT- 2014/11/27 06:00
MHDA- 2015/08/25 06:00
PMCR- 2014/11/21
CRDT- 2014/11/27 06:00
PHST- 2014/07/10 00:00 [received]
PHST- 2014/09/22 00:00 [accepted]
PHST- 2014/11/27 06:00 [entrez]
PHST- 2014/11/27 06:00 [pubmed]
PHST- 2015/08/25 06:00 [medline]
PHST- 2014/11/21 00:00 [pmc-release]
AID - S0100-879X2014005044195 [pii]
AID - 10.1590/1414-431X20144195 [doi]
PST - ppublish
SO  - Braz J Med Biol Res. 2015 Feb;48(2):161-6. doi: 10.1590/1414-431X20144195. Epub 
      2014 Nov 21.