PMID- 25424430
OWN - NLM
STAT- MEDLINE
DCOM- 20150612
LR  - 20181113
IS  - 1759-0914 (Electronic)
IS  - 1759-0914 (Linking)
VI  - 6
IP  - 6
DP  - 2014
TI  - Hypothermia modulates cytokine responses after neonatal rat hypoxic-ischemic 
      injury and reduces brain damage.
LID - 10.1177/1759091414558418 [doi]
LID - 1759091414558418
AB  - While hypothermia (HT) is the standard-of-care for neonates with hypoxic ischemic 
      injury (HII), the mechanisms underlying its neuroprotective effect are poorly 
      understood. We examined ischemic core/penumbra and cytokine/chemokine evolution 
      in a 10-day-old rat pup model of HII. Pups were treated for 24 hr after HII with 
      HT (32℃; n = 18) or normothermia (NT, 35℃; n = 15). Outcomes included magnetic 
      resonance imaging (MRI), neurobehavioral testing, and brain cytokine/chemokine 
      profiling (0, 24, 48, and 72 hr post-HII). Lesion volumes (24 hr) were reduced in 
      HT pups (total 74%, p < .05; penumbra 68%, p < .05; core 85%, p = .19). Lesion 
      volumes rebounded at 72 hr (48 hr post-HT) with no significant differences 
      between NT and HT pups. HT reduced interleukin-1beta (IL-1beta) at all time points 
      (p < .05); monocyte chemoattractant protein-1 (MCP-1) trended toward being 
      decreased in HT pups (p = .09). The stem cell signaling molecule, stromal 
      cell-derived factor-1 (SDF-1) was not altered by HT. Our data demonstrate that HT 
      reduces total and penumbral lesion volumes (at 24 and 48 hr), potentially by 
      decreasing IL-1beta without affecting SDF-1. Disassociation between the increasing 
      trend in HII volumes from 48 to 72 hr post-HII when IL-1beta levels remained low 
      suggests that after rewarming, mechanisms unrelated to IL-1beta expression are 
      likely to contribute to this delayed increase in injury. Additional studies 
      should be considered to determine what these mechanisms might be and also to 
      explore whether extending the duration or degree of HT might ameliorate this 
      delayed increase in injury.
CI  - (c) The Author(s) 2014.
FAU - Yuan, Xiangpeng
AU  - Yuan X
AD  - Department of Pediatrics, Loma Linda University, CA, USA.
FAU - Ghosh, Nirmalya
AU  - Ghosh N
AD  - Department of Pediatrics, Loma Linda University, CA, USA.
FAU - McFadden, Brian
AU  - McFadden B
AD  - Department of Pediatrics, Loma Linda University, CA, USA Department of Biological 
      Sciences, California State University, Fullerton, CA, USA.
FAU - Tone, Beatriz
AU  - Tone B
AD  - Department of Pediatrics, Loma Linda University, CA, USA.
FAU - Bellinger, Denise L
AU  - Bellinger DL
AD  - Department of Pathology and Human Anatomy, Loma Linda University, CA, USA.
FAU - Obenaus, Andre
AU  - Obenaus A
AD  - Department of Pediatrics, Loma Linda University, CA, USA Cell, Molecular, and 
      Developmental Biology Graduate Program, Neuroscience Graduate Program, University 
      of California, Riverside, CA, USA.
FAU - Ashwal, Stephen
AU  - Ashwal S
AD  - Department of Pediatrics, Loma Linda University, CA, USA sashwal@llu.edu.
LA  - eng
GR  - R01 NS059770/NS/NINDS NIH HHS/United States
GR  - 1R01NS059770-01A2/NS/NINDS NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20141124
PL  - United States
TA  - ASN Neuro
JT  - ASN neuro
JID - 101507115
RN  - 0 (Cytokines)
SB  - IM
MH  - Analysis of Variance
MH  - Animals
MH  - Animals, Newborn
MH  - Cytokines/*metabolism
MH  - Diffusion Magnetic Resonance Imaging
MH  - Disease Models, Animal
MH  - Hypothermia, Induced/*methods
MH  - Hypoxia-Ischemia, Brain/complications/pathology/*therapy
MH  - Magnetic Resonance Imaging
MH  - Movement Disorders/etiology/prevention & control
MH  - Neurologic Examination
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Regression Analysis
PMC - PMC4357606
OTO - NOTNLM
OT  - MRI
OT  - chemokines
OT  - cytokines
OT  - hypothermia
OT  - inflammation
OT  - neonatal ischemia
EDAT- 2014/11/27 06:00
MHDA- 2015/06/13 06:00
PMCR- 2014/11/21
CRDT- 2014/11/27 06:00
PHST- 2014/11/27 06:00 [entrez]
PHST- 2014/11/27 06:00 [pubmed]
PHST- 2015/06/13 06:00 [medline]
PHST- 2014/11/21 00:00 [pmc-release]
AID - 6/6/1759091414558418 [pii]
AID - 10.1177_1759091414558418 [pii]
AID - 10.1177/1759091414558418 [doi]
PST - epublish
SO  - ASN Neuro. 2014 Nov 24;6(6):1759091414558418. doi: 10.1177/1759091414558418. 
      Print 2014.