PMID- 25425223
OWN - NLM
STAT- MEDLINE
DCOM- 20161213
LR  - 20191114
IS  - 1098-2825 (Electronic)
IS  - 0887-8013 (Print)
IS  - 0887-8013 (Linking)
VI  - 30
IP  - 2
DP  - 2016 Mar
TI  - Influence of Body Mass Index on the Activated Clotting Time Under Weight-Based 
      Heparin Dose.
PG  - 108-13
LID - 10.1002/jcla.21823 [doi]
AB  - BACKGROUND: Activated clotting time (ACT) has been successfully applied during 
      percutaneous coronary intervention (PCI) to monitor the extent of thrombin 
      inhibition and anti-coagulation from unfractionated heparin (UFH) aiming to 
      reduce the incidence of thrombotic adverse events and hemorrhagic complications. 
      And this investigation was to explore the influence of body mass index (BMI) on 
      ACT in patients received weight-based dose of UFH during PCI treatment. METHODS: 
      78 male patients undergoing coronary angiography or PCI treatment with a mean age 
      of 63.86 +/- 6.89 years were enrolled in this study. The patients were 
      statistically divided into four quartiles according to their BMI. The ACT values 
      were recorded as ACT0 , ACT5 , ACT10 , ACT30 and ACT60 , respectively. Taking the 
      preoperative ACT0 as reference, and the differences of the other ACT values with 
      ACT0 was indicated as DeltaACTs. ACT values peaked at 5 min in 33.33% of the 
      patients, 10 min in 51.33% of the patients and 30 min in 15.34% of the patients, 
      respectively. RESULTS: In addition, significant differences were found in overall 
      maximum post-UFH ACT values among all BMI quartiles. UFH doses per blood volume 
      were significantly different among the BMI quartiles, showing a positive 
      association with BMI quartiles; further evidence revealed that the areas under 
      the DeltaACT-time curves increased gradually from quartile I to quartile IV. The 
      proportions of ACT60 > 250 s and ACT60 > 300 s were found to be positively 
      correlated with the increased BMI at 60 min after heparin loading. CONCLUSIONS: 
      The results of our study have shown that a standardized dosing nomogram that uses 
      the actual body weight to calculate the heparin doses may result in UFH overdose 
      for patients with higher BMI compared to patients with lower BMI.
CI  - (c) 2014 Wiley Periodicals, Inc.
FAU - Hong, Xia
AU  - Hong X
AD  - Department of Cardiology, The First Affiliated Hospital, Wenzhou Medical College, 
      Wenzhou, P.R. China.
FAU - Shan, Pei-Ren
AU  - Shan PR
AD  - Department of Cardiology, The First Affiliated Hospital, Wenzhou Medical College, 
      Wenzhou, P.R. China.
FAU - Huang, Wei-Jian
AU  - Huang WJ
AD  - Department of Cardiology, The First Affiliated Hospital, Wenzhou Medical College, 
      Wenzhou, P.R. China.
FAU - Zhu, Qian-Li
AU  - Zhu QL
AD  - Department of Cardiology, The First Affiliated Hospital, Wenzhou Medical College, 
      Wenzhou, P.R. China.
FAU - Xiao, Fang-Yi
AU  - Xiao FY
AD  - Department of Cardiology, The First Affiliated Hospital, Wenzhou Medical College, 
      Wenzhou, P.R. China.
FAU - Li, Sheng
AU  - Li S
AD  - Department of Cardiology, The First Affiliated Hospital, Wenzhou Medical College, 
      Wenzhou, P.R. China.
FAU - Zhou, Hao
AU  - Zhou H
AD  - Department of Cardiology, The First Affiliated Hospital, Wenzhou Medical College, 
      Wenzhou, P.R. China.
LA  - eng
PT  - Clinical Trial
PT  - Journal Article
DEP - 20141125
PL  - United States
TA  - J Clin Lab Anal
JT  - Journal of clinical laboratory analysis
JID - 8801384
RN  - 9005-49-6 (Heparin)
SB  - IM
MH  - Aged
MH  - Blood Coagulation/*drug effects
MH  - *Body Mass Index
MH  - Body Weight/*drug effects
MH  - Dose-Response Relationship, Drug
MH  - Heparin/administration & dosage/*pharmacology
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Time Factors
PMC - PMC6807074
OTO - NOTNLM
OT  - activated blotting time
OT  - body mass index
OT  - unfractionated heparin
COIS- None declared.
EDAT- 2014/11/27 06:00
MHDA- 2016/12/15 06:00
PMCR- 2014/11/25
CRDT- 2014/11/27 06:00
PHST- 2014/06/30 00:00 [received]
PHST- 2014/10/22 00:00 [accepted]
PHST- 2014/11/27 06:00 [entrez]
PHST- 2014/11/27 06:00 [pubmed]
PHST- 2016/12/15 06:00 [medline]
PHST- 2014/11/25 00:00 [pmc-release]
AID - JCLA21823 [pii]
AID - 10.1002/jcla.21823 [doi]
PST - ppublish
SO  - J Clin Lab Anal. 2016 Mar;30(2):108-13. doi: 10.1002/jcla.21823. Epub 2014 Nov 
      25.