PMID- 25425456
OWN - NLM
STAT- MEDLINE
DCOM- 20150406
LR  - 20181113
IS  - 1744-9081 (Electronic)
IS  - 1744-9081 (Linking)
VI  - 10
DP  - 2014 Nov 25
TI  - The role of the brain-derived neurotrophic factor genotype and parenting in early 
      life in predicting externalizing and internalizing symptoms in children with 
      attention-deficit hyperactivity disorder.
PG  - 43
LID - 10.1186/1744-9081-10-43 [doi]
LID - 43
AB  - BACKGROUND: We aimed to determine whether early parenting is associated with 
      externalizing and internalizing symptoms in children with attention-deficit 
      hyperactivity disorder (ADHD) and whether such an association is affected by the 
      brain-derived neurotrophic factor (BDNF) val66met polymorphism. METHODS: The 
      participants included 92 patients with ADHD aged 6-15 years. Measures of 
      parenting in early life and externalizing and internalizing symptoms and the 
      genotype of the BDNF Val66Met polymorphism were obtained. RESULTS: The degree to 
      which the baby's autonomy was allowed was significantly and negatively correlated 
      with the CDI scores in ADHD children (r = -0.38, p = 0.005). After adjusting for 
      the child's gender, the child's age, the family's gross annual income, and the 
      maternal education level, there was a significant interaction for the BDNF 
      genotype and mother's positive feelings about caring in relation to the 
      development of childhood anxiety/depression in ADHD children (F = 2.51, 
      p = 0.011). CONCLUSIONS: Our results provide evidence of an interaction between 
      the BDNF met allele and early parenting on the development of depression/anxiety 
      symptoms.
FAU - Park, Subin
AU  - Park S
FAU - Kim, Bung-Nyun
AU  - Kim BN
FAU - Kim, Jae-Won
AU  - Kim JW
FAU - Jung, Yeon-Kyung
AU  - Jung YK
FAU - Lee, Jin
AU  - Lee J
FAU - Shin, Min-Sup
AU  - Shin MS
FAU - Yoo, Hee Jeong
AU  - Yoo HJ
FAU - Cho, Soo-Churl
AU  - Cho SC
AD  - Deparment of Psychiatry and Behavioral Science, Seoul National University College 
      of Medicine, Seoul, Republic of Korea. soochurl@snu.ac.kr.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20141125
PL  - England
TA  - Behav Brain Funct
JT  - Behavioral and brain functions : BBF
JID - 101245751
RN  - 0 (Brain-Derived Neurotrophic Factor)
SB  - IM
MH  - Adolescent
MH  - Anxiety/etiology/psychology
MH  - Attention Deficit Disorder with Hyperactivity/complications/*genetics/*psychology
MH  - Brain-Derived Neurotrophic Factor/*genetics
MH  - Child
MH  - Depression/etiology/psychology
MH  - Diagnostic and Statistical Manual of Mental Disorders
MH  - Educational Status
MH  - Female
MH  - Genotype
MH  - Humans
MH  - Male
MH  - Mothers/psychology
MH  - Parenting/*psychology
MH  - Personal Autonomy
MH  - Polymorphism, Single Nucleotide/genetics
MH  - Psychiatric Status Rating Scales
MH  - Socioeconomic Factors
PMC - PMC4289369
EDAT- 2014/11/27 06:00
MHDA- 2015/04/07 06:00
PMCR- 2014/11/25
CRDT- 2014/11/27 06:00
PHST- 2014/06/15 00:00 [received]
PHST- 2014/10/23 00:00 [accepted]
PHST- 2014/11/27 06:00 [entrez]
PHST- 2014/11/27 06:00 [pubmed]
PHST- 2015/04/07 06:00 [medline]
PHST- 2014/11/25 00:00 [pmc-release]
AID - 1744-9081-10-43 [pii]
AID - 514 [pii]
AID - 10.1186/1744-9081-10-43 [doi]
PST - epublish
SO  - Behav Brain Funct. 2014 Nov 25;10:43. doi: 10.1186/1744-9081-10-43.