PMID- 25426068
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20141126
LR  - 20200930
IS  - 1663-4365 (Print)
IS  - 1663-4365 (Electronic)
IS  - 1663-4365 (Linking)
VI  - 6
DP  - 2014
TI  - Bioenergetic dysfunction and inflammation in Alzheimer's disease: a possible 
      connection.
PG  - 311
LID - 10.3389/fnagi.2014.00311 [doi]
LID - 311
AB  - Inflammation is observed in Alzheimer's disease (AD) subject brains. 
      Inflammation-relevant genes are increasingly implicated in AD genetic studies, 
      and inflammatory cytokines to some extent even function as peripheral biomarkers. 
      What underlies AD inflammation is unclear, but no "foreign" agent has been 
      implicated. This suggests that internally produced damage-associated molecular 
      pattern (DAMPs) molecules may drive inflammation in AD. A more complete 
      characterization and understanding of AD-relevant DAMPs could advance our 
      understanding of AD and suggest novel therapeutic strategies. In this review, we 
      consider the possibility that mitochondria, intracellular organelles that 
      resemble bacteria in many ways, trigger and maintain chronic inflammation in AD 
      subjects. Data supporting the possible nexus between AD-associated bioenergetic 
      dysfunction are discussed.
FAU - Wilkins, Heather M
AU  - Wilkins HM
AD  - Department of Neurology, University of Kansas Medical Center , Kansas City, KS , 
      USA ; University of Kansas Alzheimer's Disease Center, University of Kansas 
      Medical Center , Kansas City, KS , USA.
FAU - Carl, Steven M
AU  - Carl SM
AD  - University of Kansas Alzheimer's Disease Center, University of Kansas Medical 
      Center , Kansas City, KS , USA.
FAU - Greenlief, Alison C S
AU  - Greenlief AC
AD  - University of Kansas Alzheimer's Disease Center, University of Kansas Medical 
      Center , Kansas City, KS , USA.
FAU - Festoff, Barry W
AU  - Festoff BW
AD  - Department of Neurology, University of Kansas Medical Center , Kansas City, KS , 
      USA ; Department of Pharmacology, University of Kansas Medical Center , Kansas 
      City, KS , USA ; Department of Molecular and Integrative Physiology, University 
      of Kansas Medical Center , Kansas City, KS , USA ; pHLOGISTIX Neurodiagnostics , 
      Lenexa, KS , USA.
FAU - Swerdlow, Russell H
AU  - Swerdlow RH
AD  - Department of Neurology, University of Kansas Medical Center , Kansas City, KS , 
      USA ; University of Kansas Alzheimer's Disease Center, University of Kansas 
      Medical Center , Kansas City, KS , USA ; Department of Molecular and Integrative 
      Physiology, University of Kansas Medical Center , Kansas City, KS , USA ; 
      Department of Biochemistry and Molecular Biology, University of Kansas Medical 
      Center , Kansas City, KS , USA.
LA  - eng
GR  - P30 AG035982/AG/NIA NIH HHS/United States
PT  - Journal Article
PT  - Review
DEP - 20141110
PL  - Switzerland
TA  - Front Aging Neurosci
JT  - Frontiers in aging neuroscience
JID - 101525824
PMC - PMC4226164
OTO - NOTNLM
OT  - Alzheimer's disease
OT  - DAMP
OT  - bioenergetics
OT  - inflammation
OT  - mitochondria
EDAT- 2014/11/27 06:00
MHDA- 2014/11/27 06:01
PMCR- 2014/01/01
CRDT- 2014/11/27 06:00
PHST- 2014/09/10 00:00 [received]
PHST- 2014/10/23 00:00 [accepted]
PHST- 2014/11/27 06:00 [entrez]
PHST- 2014/11/27 06:00 [pubmed]
PHST- 2014/11/27 06:01 [medline]
PHST- 2014/01/01 00:00 [pmc-release]
AID - 10.3389/fnagi.2014.00311 [doi]
PST - epublish
SO  - Front Aging Neurosci. 2014 Nov 10;6:311. doi: 10.3389/fnagi.2014.00311. 
      eCollection 2014.