PMID- 25426265
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20141126
LR  - 20200930
IS  - 1949-8454 (Print)
IS  - 1949-8454 (Electronic)
IS  - 1949-8454 (Linking)
VI  - 5
IP  - 4
DP  - 2014 Nov 26
TI  - New insight in expression, transport, and secretion of brain-derived neurotrophic 
      factor: Implications in brain-related diseases.
PG  - 409-28
LID - 10.4331/wjbc.v5.i4.409 [doi]
AB  - Brain-derived neurotrophic factor (BDNF) attracts increasing attention from both 
      research and clinical fields because of its important functions in the central 
      nervous system. An adequate amount of BDNF is critical to develop and maintain 
      normal neuronal circuits in the brain. Given that loss of BDNF function has been 
      reported in the brains of patients with neurodegenerative or psychiatric 
      diseases, understanding basic properties of BDNF and associated intracellular 
      processes is imperative. In this review, we revisit the gene structure, 
      transcription, translation, transport and secretion mechanisms of BDNF. We also 
      introduce implications of BDNF in several brain-related diseases including 
      Alzheimer's disease, Huntington's disease, depression and schizophrenia.
FAU - Adachi, Naoki
AU  - Adachi N
AD  - Naoki Adachi, Tadahiro Numakawa, Shingo Nakajima, Hiroshi Kunugi, Department of 
      Mental Disorder Research, National Institute of Neuroscience, National Center of 
      Neurology and Psychiatry, Tokyo 187-8502, Japan.
FAU - Numakawa, Tadahiro
AU  - Numakawa T
AD  - Naoki Adachi, Tadahiro Numakawa, Shingo Nakajima, Hiroshi Kunugi, Department of 
      Mental Disorder Research, National Institute of Neuroscience, National Center of 
      Neurology and Psychiatry, Tokyo 187-8502, Japan.
FAU - Richards, Misty
AU  - Richards M
AD  - Naoki Adachi, Tadahiro Numakawa, Shingo Nakajima, Hiroshi Kunugi, Department of 
      Mental Disorder Research, National Institute of Neuroscience, National Center of 
      Neurology and Psychiatry, Tokyo 187-8502, Japan.
FAU - Nakajima, Shingo
AU  - Nakajima S
AD  - Naoki Adachi, Tadahiro Numakawa, Shingo Nakajima, Hiroshi Kunugi, Department of 
      Mental Disorder Research, National Institute of Neuroscience, National Center of 
      Neurology and Psychiatry, Tokyo 187-8502, Japan.
FAU - Kunugi, Hiroshi
AU  - Kunugi H
AD  - Naoki Adachi, Tadahiro Numakawa, Shingo Nakajima, Hiroshi Kunugi, Department of 
      Mental Disorder Research, National Institute of Neuroscience, National Center of 
      Neurology and Psychiatry, Tokyo 187-8502, Japan.
LA  - eng
PT  - Journal Article
PT  - Review
PL  - United States
TA  - World J Biol Chem
JT  - World journal of biological chemistry
JID - 101546471
PMC - PMC4243146
OTO - NOTNLM
OT  - Brain-derived neurotrophic factor
OT  - Neurodegenerative disorders
OT  - Psychiatric disorders
OT  - Secretion
OT  - Transcription
OT  - Transport
EDAT- 2014/11/27 06:00
MHDA- 2014/11/27 06:01
PMCR- 2014/11/26
CRDT- 2014/11/27 06:00
PHST- 2014/02/23 00:00 [received]
PHST- 2014/06/30 00:00 [revised]
PHST- 2014/08/27 00:00 [accepted]
PHST- 2014/11/27 06:00 [entrez]
PHST- 2014/11/27 06:00 [pubmed]
PHST- 2014/11/27 06:01 [medline]
PHST- 2014/11/26 00:00 [pmc-release]
AID - 10.4331/wjbc.v5.i4.409 [doi]
PST - ppublish
SO  - World J Biol Chem. 2014 Nov 26;5(4):409-28. doi: 10.4331/wjbc.v5.i4.409.