PMID- 25427163
OWN - NLM
STAT- MEDLINE
DCOM- 20150817
LR  - 20150603
IS  - 1534-6080 (Electronic)
IS  - 0041-1337 (Linking)
VI  - 99
IP  - 6
DP  - 2015 Jun
TI  - Human leukocyte antigen type and posttransplant lymphoproliferative disorder.
PG  - 1220-5
LID - 10.1097/TP.0000000000000487 [doi]
AB  - BACKGROUND: Posttransplant lymphoproliferative disorder (PTLD) is an infrequent 
      but serious complication of solid organ transplantation. Early detection and 
      initiation of therapy may improve outcomes. The purpose of this study was to 
      identify human leukocyte antigen (HLA) type as risk and prognostic factors for 
      PTLD. METHODS: A review was undertaken to identify PTLD cases treated at our 
      institution over the past 25 years. Logistic regression and Cox Proportional 
      Hazards were used to model risk factors for PTLD and clinical outcomes in 
      patients with PTLD. RESULTS: One hundred six cases of PTLD were identified with 
      1392 solid-organ transplant recipient controls. Epstein-Barr virus (EBV) 
      seronegative status pretransplant (odds ratio [OR] = 7.61, 95% confidence 
      interval [95% CI] = 3.83-15.1) and receipt of a nonkidney transplant were 
      associated with an increased risk of PTLD. Being African American and receipt of 
      a living-related kidney transplant were associated with a decreased risk of PTLD. 
      The HLA-B40 group was a risk factor for PTLD in EBV-seronegative individuals (OR 
      = 8.38, 95% CI = 2.18-32.3), whereas HLA-B8 was a risk factor for PTLD in 
      EBV-seropositive individuals (OR = 3.29, 95% CI = 1.52-7.09). Specific HLA types 
      were not associated with graft failure or mortality after PTLD diagnosis. In PTLD 
      patients, central nervous system (CNS) involvement, bone marrow involvement, 
      T-cell PTLD, and age were associated with increased mortality. CONCLUSION: Human 
      leukocyte antigen-B40 group and HLA-B8 were identified as novel susceptibility 
      factors for PTLD in EBV-seropositive and EBV-seronegative individuals, 
      respectively. Multicentered, large prospective studies of PTLD with correlative 
      immunologic work are needed to test the significance of these observed 
      associations.
FAU - Lustberg, Mark E
AU  - Lustberg ME
AD  - 1 Division of Infectious Diseases, Department of Internal Medicine, The Ohio 
      State University Wexner Medical Center, Columbus, OH. 2 Division of 
      Transplantation Surgery, Department of Surgery, The Ohio State University Wexner 
      Medical Center, Columbus, OH. 3 Division of Hematology, Department of Internal 
      Medicine, The Ohio State University Wexner Medical Center, Columbus, OH. 4 The 
      Ohio State University Comprehensive Cancer Center, Arthur G. James Cancer 
      Hospital and Richard J. Solove Research Institute, Columbus, OH.
FAU - Pelletier, Ronald P
AU  - Pelletier RP
FAU - Porcu, Pierluigi
AU  - Porcu P
FAU - Martin, Stanley I
AU  - Martin SI
FAU - Quinion, Carl D
AU  - Quinion CD
FAU - Geyer, Susan M
AU  - Geyer SM
FAU - Caligiuri, Michael A
AU  - Caligiuri MA
FAU - Baiocchi, Robert A
AU  - Baiocchi RA
LA  - eng
GR  - NIH T32CA090223/CA/NCI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Transplantation
JT  - Transplantation
JID - 0132144
RN  - 0 (HLA Antigens)
RN  - 0 (HLA-B40 Antigen)
RN  - 0 (HLA-B8 Antigen)
SB  - IM
MH  - Adult
MH  - Case-Control Studies
MH  - Cohort Studies
MH  - Disease Susceptibility
MH  - Epstein-Barr Virus Infections/complications/immunology
MH  - Female
MH  - *HLA Antigens
MH  - HLA-B40 Antigen
MH  - HLA-B8 Antigen
MH  - Histocompatibility Testing
MH  - Humans
MH  - Kaplan-Meier Estimate
MH  - Lymphoproliferative Disorders/*etiology/*immunology/mortality
MH  - Male
MH  - Middle Aged
MH  - Ohio/epidemiology
MH  - Organ Transplantation/*adverse effects/mortality
MH  - Postoperative Complications/*etiology/*immunology/mortality
MH  - Prognosis
MH  - Retrospective Studies
MH  - Risk Factors
EDAT- 2014/11/27 06:00
MHDA- 2015/08/19 06:00
CRDT- 2014/11/27 06:00
PHST- 2014/11/27 06:00 [entrez]
PHST- 2014/11/27 06:00 [pubmed]
PHST- 2015/08/19 06:00 [medline]
AID - 10.1097/TP.0000000000000487 [doi]
PST - ppublish
SO  - Transplantation. 2015 Jun;99(6):1220-5. doi: 10.1097/TP.0000000000000487.