PMID- 25428250
OWN - NLM
STAT- MEDLINE
DCOM- 20160229
LR  - 20220311
IS  - 1875-8908 (Electronic)
IS  - 1387-2877 (Linking)
VI  - 45
IP  - 1
DP  - 2015
TI  - Cathepsin D in a murine model of frontotemporal dementia with Parkinsonism-linked 
      to chromosome 17.
PG  - 1-14
LID - 10.3233/JAD-140456 [doi]
AB  - Tauopathies, such as Alzheimer's disease (AD) and Frontotemporal dementia with 
      Parkinsonism linked to chromosome 17 (FTDP-17), are characterized by tau 
      accumulation. This accumulation could result from alterations in tau degradation 
      by either the ubiquitin-proteasome system or the autophagy-lysosomal pathway. To 
      analyze a possible alteration of the autophagy-lysosomal pathway in transgenic 
      mice expressing human tau with three FTDP-17 missense mutations (TauVLW mice), we 
      studied the lysosomal enzyme Cathepsin D. The hippocampi of TauVLW mice, where 
      the human mutant tau accumulates, showed both increased Cathepsin D and partial 
      colocalization of Cathepsin D with human mutant tau. At the ultrastructural 
      level, some multivesicular bodies showed human mutant tau-immunopositive 
      vesicles. This finding could provide insights into the molecular mechanisms of 
      tau degradation in human tauopathies.
FAU - Fernandez-Montoya, Julia
AU  - Fernandez-Montoya J
AD  - Departamento de Anatomia, Histologia y Neurociencia, Facultad de Medicina, 
      Universidad Autonoma de Madrid, Madrid, Spain.
FAU - Perez, Mar
AU  - Perez M
AD  - Departamento de Anatomia, Histologia y Neurociencia, Facultad de Medicina, 
      Universidad Autonoma de Madrid, Madrid, Spain.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Netherlands
TA  - J Alzheimers Dis
JT  - Journal of Alzheimer's disease : JAD
JID - 9814863
RN  - 0 (Nerve Tissue Proteins)
RN  - 0 (tau Proteins)
RN  - EC 3.4.23.5 (Cathepsin D)
SB  - IM
MH  - Age Factors
MH  - Animals
MH  - Cathepsin D/*metabolism
MH  - Chromosomes, Human, Pair 17/*genetics
MH  - Disease Models, Animal
MH  - Frontotemporal Dementia/*genetics
MH  - Gene Expression Regulation, Enzymologic/*genetics
MH  - Hippocampus/*enzymology/pathology/ultrastructure
MH  - Humans
MH  - Mice
MH  - Mice, Inbred C57BL
MH  - Mice, Transgenic
MH  - Microscopy, Confocal
MH  - Microscopy, Electron, Scanning
MH  - Mutation, Missense
MH  - Nerve Tissue Proteins/metabolism
MH  - tau Proteins/genetics
OTO - NOTNLM
OT  - Cathepsin D
OT  - FTDP-17
OT  - lysosomal system
OT  - mutated tau
EDAT- 2014/11/28 06:00
MHDA- 2016/03/02 06:00
CRDT- 2014/11/28 06:00
PHST- 2014/11/28 06:00 [entrez]
PHST- 2014/11/28 06:00 [pubmed]
PHST- 2016/03/02 06:00 [medline]
AID - T438232510L11851 [pii]
AID - 10.3233/JAD-140456 [doi]
PST - ppublish
SO  - J Alzheimers Dis. 2015;45(1):1-14. doi: 10.3233/JAD-140456.