PMID- 25428944
OWN - NLM
STAT- MEDLINE
DCOM- 20160208
LR  - 20161125
IS  - 2047-2412 (Electronic)
IS  - 2047-2404 (Linking)
VI  - 16
IP  - 4
DP  - 2015 Apr
TI  - Exercise echocardiography and cardiac magnetic resonance imaging to predict 
      outcome in patients with hypertrophic cardiomyopathy.
PG  - 423-32
LID - 10.1093/ehjci/jeu225 [doi]
AB  - AIMS: We have observed that wall motion abnormalities (WMAs) during exercise 
      echocardiography (ExE) are associated to events in hypertrophic cardiomyopathy 
      (HCM). Our objective was to evaluate ExE and cardiac magnetic resonance (CMR) to 
      predict outcome in HCM. METHODS AND RESULTS: ExE and CMR were performed in 148 
      patients with HCM. During follow-up (7.1 +/- 2.7 years), there were 7 hard events 
      (Hard-E) and 26 combined events (Comb-E). Exercise WMAs were observed in 13 
      patients (8.8%), perfusion defects in 10 (6.8%), and late gadolinium enhancement 
      (LGE) in 48 (32.4%). WMAs were seen in 57% of patients with Hard-E vs. 6% without 
      (P = 0.001) and in 23 and 6% with and without Comb-E (P = 0.005). Perfusion 
      defects were also more frequent in patients with Hard-E than without (43 vs. 5%, 
      P = 0.007) and in patients with Comb-E than without (23 vs. 5%, P = 0.002). LGE 
      (g) was greater in patients with Comb-E than without [median (25th-75th 
      percentile) 0 (0-21.1) vs. 0 (0-9.3) g P = 0.04]. Univariable predictors of 
      Comb-E included NYHA class >/=2, peak double product, DeltaWMSI, and CMR data. Peak 
      double product [Hazard ratios (HR) = 0.99, confidence intervals (CI) 95% 
      0.99-0.99, P = 0.02] and DeltaWMSI (HR = 404, CI 95% 12-13681, P = 0.001) remained 
      independent predictors. Peak WMSI correlated with myocardial mass with LGE (r = 
      0.20, P = 0.02) and with perfusion defect area (r = 0.40, P < 0.001). LGE 
      affecting >/=15% of the left ventricle was observed in 38% of patients with 
      exercise WMAs vs. 12% without (P = 0.009). CONCLUSION: CMR data are associated to 
      exercise WMAs in patients with HCM. ExE and CMR may help to predict outcome in 
      them.
CI  - Published on behalf of the European Society of Cardiology. All rights reserved. (c) 
      The Author 2014. For permissions please email: journals.permissions@oup.com.
FAU - Peteiro, Jesus
AU  - Peteiro J
AD  - Department of Cardiology, Complexo Hospitalario Universitario de A Coruna (CHUAC) 
      and INIBIC (Instituto de Investigacion Biomedica de A Coruna), Universidad de A 
      Coruna, P/Ronda 5-4 degrees  izda, 15011 A Coruna, Spain pete@canalejo.org.
FAU - Fernandez, Xusto
AU  - Fernandez X
AD  - Unit of Cardiomyopathies, Complexo Hospitalario Universitario de A Coruna 
      (CHUAC), Universidad de A Coruna, A Coruna, Spain.
FAU - Bouzas-Mosquera, Alberto
AU  - Bouzas-Mosquera A
AD  - Department of Cardiology, Complexo Hospitalario Universitario de A Coruna (CHUAC) 
      and INIBIC (Instituto de Investigacion Biomedica de A Coruna), Universidad de A 
      Coruna, P/Ronda 5-4 degrees  izda, 15011 A Coruna, Spain.
FAU - Monserrat, Lorenzo
AU  - Monserrat L
AD  - Unit of Cardiomyopathies, Complexo Hospitalario Universitario de A Coruna 
      (CHUAC), Universidad de A Coruna, A Coruna, Spain.
FAU - Mendez, Cristina
AU  - Mendez C
AD  - Department of Radiology, Complexo Hospitalario Universitario de A Coruna (CHUAC), 
      Universidad de A Coruna, A Coruna, Spain.
FAU - Rodriguez-Garcia, Esther
AU  - Rodriguez-Garcia E
AD  - Department of Radiology, Complexo Hospitalario Universitario de A Coruna (CHUAC), 
      Universidad de A Coruna, A Coruna, Spain.
FAU - Soler, Rafaela
AU  - Soler R
AD  - Department of Radiology, Complexo Hospitalario Universitario de A Coruna (CHUAC), 
      Universidad de A Coruna, A Coruna, Spain.
FAU - Couto, David
AU  - Couto D
AD  - Department of Cardiology, Complexo Hospitalario Universitario de A Coruna (CHUAC) 
      and INIBIC (Instituto de Investigacion Biomedica de A Coruna), Universidad de A 
      Coruna, P/Ronda 5-4 degrees  izda, 15011 A Coruna, Spain.
FAU - Castro-Beiras, Alfonso
AU  - Castro-Beiras A
AD  - Department of Cardiology, Complexo Hospitalario Universitario de A Coruna (CHUAC) 
      and INIBIC (Instituto de Investigacion Biomedica de A Coruna), Universidad de A 
      Coruna, P/Ronda 5-4 degrees  izda, 15011 A Coruna, Spain.
LA  - eng
PT  - Journal Article
PT  - Observational Study
DEP - 20141126
PL  - England
TA  - Eur Heart J Cardiovasc Imaging
JT  - European heart journal. Cardiovascular Imaging
JID - 101573788
RN  - 0 (Contrast Media)
RN  - AU0V1LM3JT (Gadolinium)
SB  - IM
MH  - Aged
MH  - Cardiomyopathy, Hypertrophic/*diagnosis/mortality
MH  - Cohort Studies
MH  - Contrast Media
MH  - Disease Progression
MH  - Echocardiography, Stress/*methods
MH  - Female
MH  - Follow-Up Studies
MH  - Gadolinium
MH  - Humans
MH  - Image Processing, Computer-Assisted
MH  - Kaplan-Meier Estimate
MH  - Magnetic Resonance Imaging, Cine/*methods
MH  - Male
MH  - Middle Aged
MH  - Predictive Value of Tests
MH  - Reproducibility of Results
MH  - Risk Factors
MH  - Sensitivity and Specificity
MH  - Ventricular Dysfunction, Left/*diagnostic imaging
OTO - NOTNLM
OT  - cardiac magnetic resonance
OT  - exercise echocardiography
OT  - hypertrophic cardiomyopathy
OT  - regional wall motion abnormalities
EDAT- 2014/11/28 06:00
MHDA- 2016/02/09 06:00
CRDT- 2014/11/28 06:00
PHST- 2014/11/28 06:00 [entrez]
PHST- 2014/11/28 06:00 [pubmed]
PHST- 2016/02/09 06:00 [medline]
AID - jeu225 [pii]
AID - 10.1093/ehjci/jeu225 [doi]
PST - ppublish
SO  - Eur Heart J Cardiovasc Imaging. 2015 Apr;16(4):423-32. doi: 10.1093/ehjci/jeu225. 
      Epub 2014 Nov 26.