PMID- 25429141
OWN - NLM
STAT- MEDLINE
DCOM- 20150126
LR  - 20220309
IS  - 1529-2401 (Electronic)
IS  - 0270-6474 (Print)
IS  - 0270-6474 (Linking)
VI  - 34
IP  - 48
DP  - 2014 Nov 26
TI  - A common neural code for perceived and inferred emotion.
PG  - 15997-6008
LID - 10.1523/JNEUROSCI.1676-14.2014 [doi]
AB  - Although the emotions of other people can often be perceived from overt reactions 
      (e.g., facial or vocal expressions), they can also be inferred from situational 
      information in the absence of observable expressions. How does the human brain 
      make use of these diverse forms of evidence to generate a common representation 
      of a target's emotional state? In the present research, we identify neural 
      patterns that correspond to emotions inferred from contextual information and 
      find that these patterns generalize across different cues from which an emotion 
      can be attributed. Specifically, we use functional neuroimaging to measure neural 
      responses to dynamic facial expressions with positive and negative valence and to 
      short animations in which the valence of a character's emotion could be 
      identified only from the situation. Using multivoxel pattern analysis, we test 
      for regions that contain information about the target's emotional state, 
      identifying representations specific to a single stimulus type and 
      representations that generalize across stimulus types. In regions of medial 
      prefrontal cortex (MPFC), a classifier trained to discriminate emotional valence 
      for one stimulus (e.g., animated situations) could successfully discriminate 
      valence for the remaining stimulus (e.g., facial expressions), indicating a 
      representation of valence that abstracts away from perceptual features and 
      generalizes across different forms of evidence. Moreover, in a subregion of MPFC, 
      this neural representation generalized to trials involving subjectively 
      experienced emotional events, suggesting partial overlap in neural responses to 
      attributed and experienced emotions. These data provide a step toward 
      understanding how the brain transforms stimulus-bound inputs into abstract 
      representations of emotion.
CI  - Copyright (c) 2014 the authors 0270-6474/14/3315997-12$15.00/0.
FAU - Skerry, Amy E
AU  - Skerry AE
AD  - Department of Psychology, Harvard University, Cambridge, Massachusetts 02138, and 
      amy.skerry@gmail.com.
FAU - Saxe, Rebecca
AU  - Saxe R
AD  - Department of Brain and Cognitive Sciences, Massachusetts Institute of 
      Technology, Cambridge, Massachusetts 02139.
LA  - eng
GR  - R01 MH096914/MH/NIMH NIH HHS/United States
GR  - 1R01 MH096914-01A1/MH/NIMH NIH HHS/United States
PT  - Journal Article
PT  - Randomized Controlled Trial
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, U.S. Gov't, Non-P.H.S.
PL  - United States
TA  - J Neurosci
JT  - The Journal of neuroscience : the official journal of the Society for 
      Neuroscience
JID - 8102140
SB  - IM
MH  - Adult
MH  - Brain/*physiology
MH  - Emotions/*physiology
MH  - Female
MH  - Humans
MH  - Magnetic Resonance Imaging/methods
MH  - Male
MH  - Nerve Net/*physiology
MH  - Photic Stimulation/*methods
MH  - Pilot Projects
MH  - Psychomotor Performance/*physiology
MH  - Young Adult
PMC - PMC4244468
OTO - NOTNLM
OT  - abstraction
OT  - concepts
OT  - emotion attribution
OT  - multimodal
OT  - social cognition
OT  - theory of mind
EDAT- 2014/11/28 06:00
MHDA- 2015/01/27 06:00
PMCR- 2015/05/26
CRDT- 2014/11/28 06:00
PHST- 2014/11/28 06:00 [entrez]
PHST- 2014/11/28 06:00 [pubmed]
PHST- 2015/01/27 06:00 [medline]
PHST- 2015/05/26 00:00 [pmc-release]
AID - 34/48/15997 [pii]
AID - 1676-14 [pii]
AID - 10.1523/JNEUROSCI.1676-14.2014 [doi]
PST - ppublish
SO  - J Neurosci. 2014 Nov 26;34(48):15997-6008. doi: 10.1523/JNEUROSCI.1676-14.2014.