PMID- 25429317
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20141127
LR  - 20200930
IS  - 1948-5182 (Print)
IS  - 1948-5182 (Electronic)
VI  - 6
IP  - 11
DP  - 2014 Nov 27
TI  - Role of vaptans in the management of hydroelectrolytic imbalance in liver 
      cirrhosis.
PG  - 793-9
LID - 10.4254/wjh.v6.i11.793 [doi]
AB  - Ascites and hyponatremia are the most common complications in patients with liver 
      cirrhosis and develop as a consequence of a severe impairment of liver function 
      and portal hypertension. Increasing evidences support the central role of renal 
      function alterations in the pathogenesis of hydroelectrolytic imbalances in 
      cirrhotic patients, thus implying a dense cross-talk between liver and kidney in 
      the systemic and splanchnic vascular homeostasis in such subjects. Since Arginin 
      Vasopressin (AVP) hyperincretion occurs at late stage of cirrhosis and plays an 
      important role in the development of refractory ascites, dilutional hyponatremia 
      and finally hepato-renal syndrome, selective antagonists of AVP receptors V2 
      (vaptans) have been recently introduced in the therapeutic algorithm of advanced 
      cirrhotic patients. Despite the promising results of earlier phase-two studies, 
      randomized controlled trials failed to find significant results in terms of 
      efficacy of such drugs both in refractory ascites and hyponatremia. Moreover, 
      concerns on their safety profile arise, due to the number of potentially severe 
      side effects of vaptans in the clinical setting, such as hypernatremia, 
      dehydration, renal impairment, and osmotic demyelination syndrome. More robust 
      data from randomized controlled trials are needed in order to confirm the 
      potential role of vaptans in the management of advanced cirrhotic patients.
FAU - Facciorusso, Antonio
AU  - Facciorusso A
AD  - Antonio Facciorusso, Annabianca Amoruso, Viviana Neve, Matteo Antonino, Valentina 
      Del Prete, Michele Barone, Department of Medical Sciences, Section of 
      Gastroenterology University of Foggia, 71100 Foggia, Italy.
FAU - Amoruso, Annabianca
AU  - Amoruso A
AD  - Antonio Facciorusso, Annabianca Amoruso, Viviana Neve, Matteo Antonino, Valentina 
      Del Prete, Michele Barone, Department of Medical Sciences, Section of 
      Gastroenterology University of Foggia, 71100 Foggia, Italy.
FAU - Neve, Viviana
AU  - Neve V
AD  - Antonio Facciorusso, Annabianca Amoruso, Viviana Neve, Matteo Antonino, Valentina 
      Del Prete, Michele Barone, Department of Medical Sciences, Section of 
      Gastroenterology University of Foggia, 71100 Foggia, Italy.
FAU - Antonino, Matteo
AU  - Antonino M
AD  - Antonio Facciorusso, Annabianca Amoruso, Viviana Neve, Matteo Antonino, Valentina 
      Del Prete, Michele Barone, Department of Medical Sciences, Section of 
      Gastroenterology University of Foggia, 71100 Foggia, Italy.
FAU - Prete, Valentina Del
AU  - Prete VD
AD  - Antonio Facciorusso, Annabianca Amoruso, Viviana Neve, Matteo Antonino, Valentina 
      Del Prete, Michele Barone, Department of Medical Sciences, Section of 
      Gastroenterology University of Foggia, 71100 Foggia, Italy.
FAU - Barone, Michele
AU  - Barone M
AD  - Antonio Facciorusso, Annabianca Amoruso, Viviana Neve, Matteo Antonino, Valentina 
      Del Prete, Michele Barone, Department of Medical Sciences, Section of 
      Gastroenterology University of Foggia, 71100 Foggia, Italy.
LA  - eng
PT  - Journal Article
PT  - Review
PL  - United States
TA  - World J Hepatol
JT  - World journal of hepatology
JID - 101532469
PMC - PMC4243153
OTO - NOTNLM
OT  - Arginin vasopressin
OT  - Cirrhosis
OT  - Liver
OT  - Portal hypertension
OT  - Vaptans
EDAT- 2014/11/28 06:00
MHDA- 2014/11/28 06:01
PMCR- 2014/11/27
CRDT- 2014/11/28 06:00
PHST- 2014/06/09 00:00 [received]
PHST- 2014/09/09 00:00 [revised]
PHST- 2014/10/01 00:00 [accepted]
PHST- 2014/11/28 06:00 [entrez]
PHST- 2014/11/28 06:00 [pubmed]
PHST- 2014/11/28 06:01 [medline]
PHST- 2014/11/27 00:00 [pmc-release]
AID - 10.4254/wjh.v6.i11.793 [doi]
PST - ppublish
SO  - World J Hepatol. 2014 Nov 27;6(11):793-9. doi: 10.4254/wjh.v6.i11.793.