PMID- 25429748
OWN - NLM
STAT- MEDLINE
DCOM- 20150309
LR  - 20191113
IS  - 1001-9294 (Print)
IS  - 1001-9294 (Linking)
VI  - 29
IP  - 4
DP  - 2014 Dec
TI  - Progress of targeting transforming growth factor-beta1 small interfering RNA in 
      liver fibrosis.
PG  - 231-5
AB  - Liver fibrosis is a common pathological consequence of a variety of chronic 
      stimuli, including viral, autoimmune, drug-induced, cholestatic and metabolic 
      diseases. Fibrosis is driven by a dynamic process involving increased synthesis 
      of matrix components and a failure of physiological mechanisms of matrix 
      turnover. Activation of hepatic stellate cells (HSCs) remains a central event in 
      fibrosis. HSCs are the main source of extracellular matrix (ECM). Transforming 
      growth factor-beta (TGF-Beta), which is the fibrogenic master cytokine, can induce 
      the activation of HSCs to produce a large amount of ECM, and is capable of 
      inducing apoptosis of liver cells. RNA interference (RNAi) is a novel gene 
      disruption technology. Studies have shown that small interfering RNA (siRNA) 
      targeting TGF-Beta1 may inhibit the activation and proliferation of HSCs, suppress 
      ECM synthesis and block liver fibrosis. TGF-Beta1 siRNA-mediated gene silencing 
      therapy provides a new avenue for liver fibrosis. This review summarizes recent 
      progresses in research on HSCs, TGF-Beta1 and TGF-Beta1 siRNA in liver fibrosis.
FAU - Zhou, Xuan
AU  - Zhou X
AD  - Department of Gastroenterology, Affiliated Nanhua Hospital, University of South 
      China, Hengyang, Hunan 421002, China.
FAU - Yang, Xue-feng
AU  - Yang XF
AD  - Department of Gastroenterology, Affiliated Nanhua Hospital, University of South 
      China, Hengyang, Hunan 421002, China.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - China
TA  - Chin Med Sci J
JT  - Chinese medical sciences journal = Chung-kuo i hsueh k'o hsueh tsa chih
JID - 9112559
RN  - 0 (RNA, Small Interfering)
RN  - 0 (Transforming Growth Factor beta1)
SB  - IM
MH  - Liver Cirrhosis/*therapy
MH  - RNA, Small Interfering/*genetics
MH  - Transforming Growth Factor beta1/*genetics
EDAT- 2014/11/29 06:00
MHDA- 2015/03/10 06:00
CRDT- 2014/11/29 06:00
PHST- 2014/11/29 06:00 [entrez]
PHST- 2014/11/29 06:00 [pubmed]
PHST- 2015/03/10 06:00 [medline]
AID - 10397 [pii]
AID - 10.1016/s1001-9294(14)60076-6 [doi]
PST - ppublish
SO  - Chin Med Sci J. 2014 Dec;29(4):231-5. doi: 10.1016/s1001-9294(14)60076-6.