PMID- 25429903
OWN - NLM
STAT- MEDLINE
DCOM- 20161010
LR  - 20210109
IS  - 1559-1182 (Electronic)
IS  - 0893-7648 (Linking)
VI  - 53
IP  - 1
DP  - 2016 Jan
TI  - Modulation of the NMDA Receptor Through Secreted Soluble Factors.
PG  - 299-309
LID - 10.1007/s12035-014-9009-x [doi]
AB  - Synaptic activity is a critical determinant in the formation and development of 
      excitatory synapses in the central nervous system (CNS). The excitatory current 
      is produced and regulated by several ionotropic receptors, including those that 
      respond to glutamate. These channels are in turn regulated through several 
      secreted factors that function as synaptic organizers. Specifically, Wnt, 
      brain-derived neurotrophic factor (BDNF), fibroblast growth factor (FGF), and 
      transforming growth factor (TGF) particularly regulate the N-methyl-D-aspartate 
      receptor (NMDAR) glutamatergic channel. These factors likely regulate early 
      embryonic development and directly control key proteins in the function of 
      important glutamatergic channels. Here, we review the secreted molecules that 
      participate in synaptic organization and discuss the cell signaling behind of 
      this fine regulation. Additionally, we discuss how these factors are dysregulated 
      in some neuropathologies associated with glutamatergic synaptic transmission in 
      the CNS.
FAU - Cerpa, Waldo
AU  - Cerpa W
AD  - Laboratorio de Funcion y Patologia Neuronal, Departamento de Biologia Celular y 
      Molecular, Facultad de Ciencias Biologicas, Pontificia Universidad Catolica de 
      Chile, Santiago, Chile. wcerpa@bio.puc.cl.
FAU - Ramos-Fernandez, Eva
AU  - Ramos-Fernandez E
AD  - Centro de Envejecimiento y Regeneracion (CARE), Departamento de Biologia Celular 
      y Molecular, Facultad de Ciencias Biologicas, Pontificia Universidad Catolica de 
      Chile, Santiago, Chile.
FAU - Inestrosa, Nibaldo C
AU  - Inestrosa NC
AD  - Centro de Envejecimiento y Regeneracion (CARE), Departamento de Biologia Celular 
      y Molecular, Facultad de Ciencias Biologicas, Pontificia Universidad Catolica de 
      Chile, Santiago, Chile.
AD  - Centre for Healthy Brain Ageing, School of Psychiatry, UNSW, Faculty of Medicine, 
      University of New South Wales, Sydney, Australia.
AD  - Centro de Excelencia en Biomedicina de Magallanes (CEBIMA), Universidad de 
      Magallanes, Punta Arenas, Chile.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20141129
PL  - United States
TA  - Mol Neurobiol
JT  - Molecular neurobiology
JID - 8900963
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Receptors, N-Methyl-D-Aspartate)
RN  - 0 (Wnt Proteins)
RN  - 62031-54-3 (Fibroblast Growth Factors)
RN  - 76057-06-2 (Transforming Growth Factors)
SB  - IM
MH  - Animals
MH  - Brain-Derived Neurotrophic Factor/metabolism
MH  - Fibroblast Growth Factors/metabolism
MH  - Humans
MH  - Receptors, N-Methyl-D-Aspartate/*metabolism
MH  - Solubility
MH  - Transforming Growth Factors/metabolism
MH  - Wnt Proteins/metabolism
OTO - NOTNLM
OT  - Glutamate
OT  - NMDA receptor
OT  - Neuroregulation
OT  - Neurotrophic
OT  - Soluble factors
OT  - Synapse
EDAT- 2014/11/29 06:00
MHDA- 2016/10/11 06:00
CRDT- 2014/11/29 06:00
PHST- 2014/07/30 00:00 [received]
PHST- 2014/11/14 00:00 [accepted]
PHST- 2014/11/29 06:00 [entrez]
PHST- 2014/11/29 06:00 [pubmed]
PHST- 2016/10/11 06:00 [medline]
AID - 10.1007/s12035-014-9009-x [pii]
AID - 10.1007/s12035-014-9009-x [doi]
PST - ppublish
SO  - Mol Neurobiol. 2016 Jan;53(1):299-309. doi: 10.1007/s12035-014-9009-x. Epub 2014 
      Nov 29.