PMID- 25430073
OWN - NLM
STAT- MEDLINE
DCOM- 20160907
LR  - 20151030
IS  - 1556-9535 (Electronic)
IS  - 1556-9527 (Linking)
VI  - 34
IP  - 4
DP  - 2015
TI  - Correlation between experimental human and murine skin sensitization induction 
      thresholds.
PG  - 298-302
LID - 10.3109/15569527.2014.979425 [doi]
AB  - Quantitative risk assessment for skin sensitization is directed towards the 
      determination of levels of exposure to known sensitizing substances that will 
      avoid the induction of contact allergy in humans. A key component of this work is 
      the predictive identification of relative skin sensitizing potency, achieved 
      normally by the measurement of the threshold (the "EC3" value) in the local lymph 
      node assay (LLNA). In an extended series of studies, the accuracy of this murine 
      induction threshold as the predictor of the absence of a sensitizing effect has 
      been verified by conduct of a human repeated insult patch test (HRIPT). Murine 
      and human thresholds for a diverse set of 57 fragrance chemicals spanning 
      approximately four orders of magnitude variation in potency have been compared. 
      The results confirm that there is a useful correlation, with the LLNA EC3 value 
      helping particularly to identify stronger sensitizers. Good correlation (with 
      half an order of magnitude) was seen with three-quarters of the dataset. The 
      analysis also helps to identify potential outlier types of (fragrance) chemistry, 
      exemplified by hexyl and benzyl salicylates (an over-prediction) and 
      trans-2-hexenal (an under-prediction).
FAU - Api, Anne Marie
AU  - Api AM
AD  - a Research Institute for Fragrance Materials , Woodcliff Lake , NJ , USA and.
FAU - Basketter, David
AU  - Basketter D
AD  - b DABMEB Consultancy Ltd , Sharnbrook , Bedfordshire , UK.
FAU - Lalko, Jon
AU  - Lalko J
AD  - a Research Institute for Fragrance Materials , Woodcliff Lake , NJ , USA and.
LA  - eng
PT  - Journal Article
DEP - 20141128
PL  - England
TA  - Cutan Ocul Toxicol
JT  - Cutaneous and ocular toxicology
JID - 101266892
RN  - 0 (Allergens)
RN  - 0 (Perfume)
SB  - IM
MH  - Administration, Cutaneous
MH  - Allergens/administration & dosage/*adverse effects/chemistry
MH  - Animals
MH  - Dermatitis, Allergic Contact/*diagnosis/*etiology
MH  - Differential Threshold
MH  - Disease Models, Animal
MH  - Dose-Response Relationship, Drug
MH  - Female
MH  - Humans
MH  - *Local Lymph Node Assay
MH  - Mice, Inbred CBA
MH  - No-Observed-Adverse-Effect Level
MH  - *Patch Tests
MH  - Perfume/administration & dosage/*adverse effects/chemistry
MH  - Predictive Value of Tests
MH  - Risk Assessment
OTO - NOTNLM
OT  - Contact allergy induction
OT  - EC3 value
OT  - NESIL
OT  - fragrance
OT  - human repeated insult patch test
OT  - local lymph node assay
OT  - skin sensitization
EDAT- 2014/11/29 06:00
MHDA- 2016/09/08 06:00
CRDT- 2014/11/29 06:00
PHST- 2014/11/29 06:00 [entrez]
PHST- 2014/11/29 06:00 [pubmed]
PHST- 2016/09/08 06:00 [medline]
AID - 10.3109/15569527.2014.979425 [doi]
PST - ppublish
SO  - Cutan Ocul Toxicol. 2015;34(4):298-302. doi: 10.3109/15569527.2014.979425. Epub 
      2014 Nov 28.