PMID- 25430457
OWN - NLM
STAT- MEDLINE
DCOM- 20150825
LR  - 20141128
IS  - 2542-5641 (Electronic)
IS  - 0366-6999 (Linking)
VI  - 127
IP  - 23
DP  - 2014
TI  - Allergic diseases, immunoglobulin E, and autoimmune pancreatitis: a retrospective 
      study of 22 patients.
PG  - 4104-9
AB  - BACKGROUND: Autoimmune pancreatitis (AIP) is a chronic inflammatory disease of 
      pancreas. We evaluated the clinical manifestations, imaging, and histological 
      presentations of AIP in Chinese patients, and investigated the roles of 
      immunoglobulin E (IgE) and allergic diseases in the diagnosis and pathogenesis of 
      AIP. METHODS: The clinical records of 22 patients diagnosed with AIP were 
      reviewed and analyzed. All patients with AIP fulfilled the 2006 revised 
      diagnostic criteria proposed by Japan Pancreas Society or the Korean Criteria for 
      AIP. RESULTS: Half (11/22) of AIP patients had allergic diseases. Twenty-one 
      patients had elevated serum IgE levels, and 14 patients had IgE levels more than 
      3 times that of normal. There were no significant differences between the 
      patients with higher or lower IgE, with or without allergic disease, in clinical 
      features, laboratory tests, diffuse or focal lesions, or the choice of treatment 
      methods; however, more complaints of body weight loss were observed in patients 
      with higher IgE levels. Patients with higher IgE levels and with allergic 
      diseases were more likely to have onset in March, April, May, August, September, 
      or October. IgE levels decreased after therapy, but increased again during 
      recurrence. Increased number of mast cells was found in the pancreatic tissue in 
      AIP. CONCLUSIONS: IgE maybe a useful marker for monitoring therapeutic response 
      and recurrence of AIP. Allergic processes may play an important role in the 
      pathogenesis of AIP.
FAU - Zhang, Li
AU  - Zhang L
AD  - Department of Gastroenterology, Peking University Third Hospital, Beijing 100191, 
      China.
FAU - Guo, Limei
AU  - Guo L
AD  - Department of Pathology, Peking University Health Science Center, Beijing 100191, 
      China.
FAU - Huang, Yonghui
AU  - Huang Y
AD  - Department of Gastroenterology, Peking University Third Hospital, Beijing 100191, 
      China. Email: huangyonghui@medmail.com.cn.
FAU - Wang, Tianli
AU  - Wang T
AD  - Department of Radiology, Peking University Third Hospital, Beijing 100191, China.
FAU - Shi, Xueying
AU  - Shi X
AD  - Department of Pathology, Peking University Health Science Center, Beijing 100191, 
      China.
FAU - Chang, Hong
AU  - Chang H
AD  - Department of Gastroenterology, Peking University Third Hospital, Beijing 100191, 
      China.
FAU - Yao, Wei
AU  - Yao W
AD  - Department of Gastroenterology, Peking University Third Hospital, Beijing 100191, 
      China.
FAU - Huang, Xuebiao
AU  - Huang X
AD  - Department of Gastroenterology, Peking University Third Hospital, Beijing 100191, 
      China.
LA  - eng
PT  - Journal Article
PL  - China
TA  - Chin Med J (Engl)
JT  - Chinese medical journal
JID - 7513795
RN  - 37341-29-0 (Immunoglobulin E)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Autoimmune Diseases/*blood
MH  - Female
MH  - Humans
MH  - Hypersensitivity/*blood
MH  - Immunoglobulin E/*blood
MH  - Male
MH  - Middle Aged
MH  - Pancreatitis/*blood
MH  - Retrospective Studies
EDAT- 2014/11/29 06:00
MHDA- 2015/08/26 06:00
CRDT- 2014/11/29 06:00
PHST- 2014/11/29 06:00 [entrez]
PHST- 2014/11/29 06:00 [pubmed]
PHST- 2015/08/26 06:00 [medline]
PST - ppublish
SO  - Chin Med J (Engl). 2014;127(23):4104-9.