PMID- 25431107
OWN - NLM
STAT- MEDLINE
DCOM- 20151127
LR  - 20150302
IS  - 1540-8159 (Electronic)
IS  - 0147-8389 (Linking)
VI  - 38
IP  - 3
DP  - 2015 Mar
TI  - Scar characteristics for prediction of ventricular arrhythmia in ischemic 
      cardiomyopathy.
PG  - 311-8
LID - 10.1111/pace.12536 [doi]
AB  - BACKGROUND: Better risk-stratification tools are needed to identify the best 
      candidates for implantable cardioverter defibrillator implantation. Infarct 
      characterization by cardiac magnetic resonance (CMR) has become an evolving 
      potential tool for risk stratification. OBJECTIVE: We assessed the ability of 
      scar characteristics by CMR in patients with postinfarction left ventricular (LV) 
      dysfunction to predict sustained monomorphic ventricular tachycardia (SMVT). 
      METHODS: Forty-eight patients with postinfarction LV dysfunction underwent CMR 
      study. Twenty-four patients had history of SMVT and the other 24 were control 
      group and underwent electrophysiological study to assess SMVT inducibilty. 
      Various scar characteristics were assessed in the spontaneous SMVT group and were 
      compared with the inducible and noninducible SMVT groups. RESULTS: Only six 
      patients in the control group had inducible SMVT. In univariable analysis, total 
      scar (absolute and as percent of LV), scar core (absolute and as percent of LV), 
      peri-infarct zone (absolute and as percent of LV), mean infarct transmurality, 
      and number of segments with late gadolinium enhancement (LGE) were statistically 
      significant predictors of spontaneous SMVT experience and SMVT inducibility. In 
      multivariable analysis, total infarct as percent of LV mass was the only 
      significant independent predictor of spontaneous SMVT experience (odds ratio [OR] 
      1.33 per% change, 95% confidence interval [CI] 1.12-1.6, P = 0.001) and SMVT 
      inducibility (OR 1.3 per% change, 95% CI 1.1-1.6, P = 0.004). CONCLUSION: 
      Characterization of myocardial infarct by LGE-CMR, specifically total infarct 
      size, is better predictor of spontaneous SMVT experience and SMVT inducibility 
      than LV ejection fraction.
CI  - (c) 2014 Wiley Periodicals, Inc.
FAU - Gouda, Sherif
AU  - Gouda S
AD  - Department of Cardiovascular Medicine, Cairo University, Cairo, Egypt.
FAU - Abdelwahab, Amir
AU  - Abdelwahab A
FAU - Salem, Mohamed
AU  - Salem M
FAU - Hamid, Magdy Abdel
AU  - Hamid MA
LA  - eng
PT  - Journal Article
DEP - 20141127
PL  - United States
TA  - Pacing Clin Electrophysiol
JT  - Pacing and clinical electrophysiology : PACE
JID - 7803944
SB  - IM
CIN - Pacing Clin Electrophysiol. 2015 Jun;38(6):775-6. PMID: 25753431
MH  - Cicatrix/*physiopathology
MH  - Female
MH  - Humans
MH  - Magnetic Resonance Imaging
MH  - Male
MH  - Middle Aged
MH  - Myocardial Ischemia/*physiopathology
MH  - Predictive Value of Tests
MH  - Prognosis
MH  - Risk Assessment
MH  - Risk Factors
MH  - Tachycardia, Ventricular/*physiopathology
MH  - Ventricular Dysfunction, Left/*physiopathology
OTO - NOTNLM
OT  - cardiac magnetic resonance
OT  - ischemic cardiomyopathy
OT  - sudden cardiac death
OT  - ventricular tachycardia
EDAT- 2014/11/29 06:00
MHDA- 2015/12/15 06:00
CRDT- 2014/11/29 06:00
PHST- 2014/07/03 00:00 [received]
PHST- 2014/09/09 00:00 [revised]
PHST- 2014/10/19 00:00 [accepted]
PHST- 2014/11/29 06:00 [entrez]
PHST- 2014/11/29 06:00 [pubmed]
PHST- 2015/12/15 06:00 [medline]
AID - 10.1111/pace.12536 [doi]
PST - ppublish
SO  - Pacing Clin Electrophysiol. 2015 Mar;38(3):311-8. doi: 10.1111/pace.12536. Epub 
      2014 Nov 27.