PMID- 25431370 OWN - NLM STAT- MEDLINE DCOM- 20160120 LR - 20180816 IS - 1557-8577 (Electronic) IS - 1549-1684 (Linking) VI - 18 IP - 1 DP - 2015 Feb TI - Meta-analysis study on the role of bone-derived neurotrophic factor Val66Met polymorphism in Parkinson's disease. PG - 40-7 LID - 10.1089/rej.2014.1612 [doi] AB - To evaluate a possible involvement of the brain-derived neurotrophic factor (BDNF) Val66Met polymorphism in susceptibility to Parkinson's disease (PD), we performed a meta-analysis of all studies on the topic published from 2002 to 2014. This article reviews and compares the data from two previous meta-analyses, including two studies not previously considered. We selected studies referring to a genetic comparison between PD patients and healthy controls, so 15 studies involving 3754 cases and 4026 controls were included in our meta-analysis. We found no association between the Val66Met polymorphism and the risk of developing PD in our overall analysis. The ethnicity-specific meta-analysis produced no significant association either. Our data do not support a major role for the BDNF Val66Met polymorphism in the pathogenesis of PD. FAU - Mariani, Stefania AU - Mariani S AD - 1 Neurology, University "Campus Biomedico" , Rome, Italy . FAU - Ventriglia, Mariacarla AU - Ventriglia M FAU - Simonelli, Illaria AU - Simonelli I FAU - Bucossi, Serena AU - Bucossi S FAU - Siotto, Mariacristina AU - Siotto M FAU - R, Rosanna Squitti AU - R RS LA - eng PT - Journal Article PT - Meta-Analysis PT - Research Support, Non-U.S. Gov't PT - Review PL - United States TA - Rejuvenation Res JT - Rejuvenation research JID - 101213381 RN - 0 (Brain-Derived Neurotrophic Factor) RN - 7171WSG8A2 (BDNF protein, human) RN - AE28F7PNPL (Methionine) RN - HG18B9YRS7 (Valine) SB - IM MH - Alleles MH - Brain-Derived Neurotrophic Factor/*genetics MH - Case-Control Studies MH - Genetic Association Studies MH - *Genetic Predisposition to Disease MH - Genotype MH - Homozygote MH - Humans MH - Methionine/genetics MH - Parkinson Disease/*genetics MH - *Polymorphism, Single Nucleotide MH - Regression Analysis MH - Valine/genetics EDAT- 2014/11/29 06:00 MHDA- 2016/01/21 06:00 CRDT- 2014/11/29 06:00 PHST- 2014/11/29 06:00 [entrez] PHST- 2014/11/29 06:00 [pubmed] PHST- 2016/01/21 06:00 [medline] AID - 10.1089/rej.2014.1612 [doi] PST - ppublish SO - Rejuvenation Res. 2015 Feb;18(1):40-7. doi: 10.1089/rej.2014.1612.