PMID- 25431606
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20141128
LR  - 20200930
IS  - 1741-427X (Print)
IS  - 1741-4288 (Electronic)
IS  - 1741-427X (Linking)
VI  - 2014
DP  - 2014
TI  - Curcumin Attenuates Angiotensin II-Induced Abdominal Aortic Aneurysm by 
      Inhibition of Inflammatory Response and ERK Signaling Pathways.
PG  - 270930
LID - 10.1155/2014/270930 [doi]
LID - 270930
AB  - Background and Objectives. Curcumin has long been used to treat age-related 
      diseases, such as atherosclerosis and coronary heart disease. In this study, we 
      explored the effects of curcumin on the development of abdominal aortic aneurysm 
      (AAA). Methods. ApoE(-/-) mice were randomly divided into 3 groups: AngII group, 
      AngII + curcumin (AngII + Cur) group (100 mg/kg/d), and the control group. 
      Miniosmotic pumps were implanted subcutaneously in ApoE(-/-) mice to deliver 
      AngII for 28 days. After 4-week treatment, abdominal aortas with AAA were 
      obtained for H&E staining, immunohistochemistry, and Western blotting. Results. 
      The results showed that curcumin treatment significantly decreased the occurrence 
      of AAA. The levels of macrophage infiltration, monocyte chemoattractant protein-1 
      (MCP-1), and tumor necrosis factors-alpha (TNF-alpha) were significantly lower in AngII + 
      Cur group than those in AngII group (all P < 0.01). The level of superoxide 
      dismutase (SOD) was significantly higher in AngII + Cur group than those in AngII 
      group (P < 0.01). The ERK1/2 phosphorylation in AngII + Cur group was 
      significantly lower than that in AngII group (P < 0.01). Conclusions. These 
      results suggested that curcumin can inhibit the AngII-induced AAA in ApoE(-/-) 
      mice, whose mechanisms include the curcumin anti-inflammation, antioxidative 
      stress, and downregulation of ERK signaling pathway.
FAU - Hao, QingQing
AU  - Hao Q
AD  - Department of Cardiology, Shandong Provincial Hospital Affiliated to Shandong 
      University, Jinan, Shandong 250021, China ; The Key Laboratory of Cardiovascular 
      Remodeling and Function Research, Qilu Hospital, Shandong University, Jinan, 
      Shandong 250012, China ; Department of Pathophysiology, Fenyang College Shanxi 
      Medical University, Fenyang, Shanxi 032200, China.
FAU - Chen, Xu
AU  - Chen X
AD  - Department of Cardiology, Shandong Provincial Hospital Affiliated to Shandong 
      University, Jinan, Shandong 250021, China ; The Key Laboratory of Cardiovascular 
      Remodeling and Function Research, Qilu Hospital, Shandong University, Jinan, 
      Shandong 250012, China.
FAU - Wang, XiaoYu
AU  - Wang X
AD  - Department of Cardiology, Shandong Provincial Hospital Affiliated to Shandong 
      University, Jinan, Shandong 250021, China ; The Key Laboratory of Cardiovascular 
      Remodeling and Function Research, Qilu Hospital, Shandong University, Jinan, 
      Shandong 250012, China.
FAU - Dong, Bo
AU  - Dong B
AUID- ORCID: 0000-0003-1201-8884
AD  - Department of Cardiology, Shandong Provincial Hospital Affiliated to Shandong 
      University, Jinan, Shandong 250021, China ; The Key Laboratory of Cardiovascular 
      Remodeling and Function Research, Qilu Hospital, Shandong University, Jinan, 
      Shandong 250012, China ; Department of Cardiology, Affiliated Hospital of 
      Shandong University of Traditional Chinese Medicine, Jinan 250011, China.
FAU - Yang, ChuanHua
AU  - Yang C
AD  - Department of Cardiology, Affiliated Hospital of Shandong University of 
      Traditional Chinese Medicine, Jinan 250011, China.
LA  - eng
PT  - Journal Article
DEP - 20141106
PL  - United States
TA  - Evid Based Complement Alternat Med
JT  - Evidence-based complementary and alternative medicine : eCAM
JID - 101215021
PMC - PMC4241315
EDAT- 2014/11/29 06:00
MHDA- 2014/11/29 06:01
PMCR- 2014/11/06
CRDT- 2014/11/29 06:00
PHST- 2014/08/06 00:00 [received]
PHST- 2014/10/12 00:00 [revised]
PHST- 2014/10/13 00:00 [accepted]
PHST- 2014/11/29 06:00 [entrez]
PHST- 2014/11/29 06:00 [pubmed]
PHST- 2014/11/29 06:01 [medline]
PHST- 2014/11/06 00:00 [pmc-release]
AID - 10.1155/2014/270930 [doi]
PST - ppublish
SO  - Evid Based Complement Alternat Med. 2014;2014:270930. doi: 10.1155/2014/270930. 
      Epub 2014 Nov 6.