PMID- 2543225
OWN - NLM
STAT- MEDLINE
DCOM- 19890706
LR  - 20220309
IS  - 0147-5185 (Print)
IS  - 0147-5185 (Linking)
VI  - 13
IP  - 6
DP  - 1989 Jun
TI  - Rhabdoid tumor of kidney. A report of 111 cases from the National Wilms' Tumor 
      Study Pathology Center.
PG  - 439-58
AB  - We review 111 cases of rhabdoid tumor of kidney (RTK), including 79 entered on 
      the National Wilms' Tumor Study (NWTS). Median age at diagnosis was 11 months, 
      with a range from 0 to 106 months. The male:female ratio was 1.5:1. Gross 
      features included a characteristic involvement of perihilar renal parenchyma. A 
      wide histological spectrum was encountered, including nine major morphological 
      patterns (classical, epithelioid, sclerosing, lymphomatoid, histiocytoid, etc.). 
      These appearances invite confusion with other renal neoplasms. Ultrastructural 
      studies were performed in 20 cases; immunocytochemical studies were performed in 
      11. Vimentin was demonstrated in all tumors; epithelial membrane antigen was seen 
      in 7. Nonspecific decoration of cytoplasmic inclusions by a variety of 
      immunostains was found in several cases. Several findings suggested that RTK 
      might arise from primitive cells involved in formation of the renal medulla. 
      There was no evidence of a histogenetic relationship to Wilms' tumor, although 
      RTK may overlap with mesoblastic nephroma and clear cell sarcoma. Of the 70 NWTS 
      patients with adequate follow-up, 56 (80%) have died. Every patient presenting 
      with distant metastases died, whereas 10 of 20 with negative nodes survived. 
      Survival rates were higher for girls (56.3% versus 11.1%). None of the 
      histological variables had independent prognostic significance.
FAU - Weeks, D A
AU  - Weeks DA
AD  - Department of Pathology, Children's Hospital, Denver, CO 80218.
FAU - Beckwith, J B
AU  - Beckwith JB
FAU - Mierau, G W
AU  - Mierau GW
FAU - Luckey, D W
AU  - Luckey DW
LA  - eng
GR  - CA-42326/CA/NCI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
PT  - Review
PL  - United States
TA  - Am J Surg Pathol
JT  - The American journal of surgical pathology
JID - 7707904
RN  - 0 (Antigens, Neoplasm)
RN  - 0 (Antigens, Surface)
RN  - 0 (Vimentin)
SB  - IM
MH  - Antigens, Neoplasm/analysis
MH  - Antigens, Surface/analysis
MH  - Child
MH  - Child, Preschool
MH  - Female
MH  - Humans
MH  - Immunohistochemistry
MH  - Infant
MH  - Kidney Neoplasms/*pathology/ultrastructure
MH  - Male
MH  - Microscopy, Electron
MH  - Sarcoma/*pathology/ultrastructure
MH  - Vimentin/analysis
MH  - Wilms Tumor/*pathology/ultrastructure
RF  - 74
EDAT- 1989/06/01 00:00
MHDA- 1989/06/01 00:01
CRDT- 1989/06/01 00:00
PHST- 1989/06/01 00:00 [pubmed]
PHST- 1989/06/01 00:01 [medline]
PHST- 1989/06/01 00:00 [entrez]
PST - ppublish
SO  - Am J Surg Pathol. 1989 Jun;13(6):439-58.