PMID- 25433039
OWN - NLM
STAT- MEDLINE
DCOM- 20150728
LR  - 20150522
IS  - 1462-0332 (Electronic)
IS  - 1462-0324 (Linking)
VI  - 54
IP  - 6
DP  - 2015 Jun
TI  - Reliability of histopathological salivary gland biopsy assessment in Sjogren's 
      syndrome: a multicentre cohort study.
PG  - 1056-64
LID - 10.1093/rheumatology/keu453 [doi]
AB  - OBJECTIVE: The aim of this study was to assess intraobserver and interobserver 
      reliability of minor salivary gland biopsy (MSGB) in SS. METHODS: All MSGBs 
      available from the Tolerance and Efficacy of Rituximab in Primary Sjogren's 
      Syndrome (TEARS) study were subjected to a standardized blinded assessment by a 
      single specifically trained pathologist twice at a 2 month interval; both the 
      Chisholm-Mason (CM) grade and the focus score (FS) were determined. Baseline 
      histopathological reports by local pathologists at each study centre were 
      compared with the first standardized blinded assessment. Agreement was assessed 
      for the dichotomized FS (dFS) and dichotomized CM (dCM) grade, as well as for 
      nine other histopathological features. RESULTS: Eighty-nine MSGBs were studied. 
      Intraobserver kappa values were 1 for dFS, 0.80 for dCM, 0.67 for germinal 
      centre-like structures, 0.44 for fibrosis and 0.29 for confluent foci. Most of 
      the local histopathological reports based their diagnosis on the CM grade, 
      although the FS was often reported or the data needed to determine it were 
      provided. Interobserver agreement kappa values were 0.71 for dFS, 0.64 for dCM, 0.46 
      for focal lymphocytic sialadenitis, 0.42 for non-specific chronic inflammation 
      and 0.16 for fibrosis. CONCLUSION: Although FS reliability was good, disparities 
      were noted in the assessment methods used by local pathologists. The protocol for 
      FS determination was not followed routinely, with the result that the FS was 
      often overestimated. Germinal centre-like structures, which predict lymphoma, 
      showed good reliability but were inconsistently reported.
CI  - (c) The Author 2014. Published by Oxford University Press on behalf of the British 
      Society for Rheumatology. All rights reserved. For Permissions, please email: 
      journals.permissions@oup.com.
FAU - Costa, Sebastian
AU  - Costa S
AD  - Pathology Department, Brest University Hospital, Brest, France, Pathology 
      Department, Vannes General Hospital, Vannes, Brest Occidental University, 
      Rheumatology Unit, Hopital de la Cavale Blanche, EA 2216, ESPRI 29, Brest 
      University, Brest, Rheumatology Department, Hotel Dieu University Hospital, 
      Nantes, Department of Internal Medicine, Nord-de-France University, Claude-Huriez 
      Hospital, Lille, Rheumatology Department, Rouen University Hospital, Rouen and 
      Brest Occidental University, Clinical Investigation Centre, Institut National de 
      la Sante et de la Recherche Medicale, Brest, France.
FAU - Quintin-Roue, Isabelle
AU  - Quintin-Roue I
AD  - Pathology Department, Brest University Hospital, Brest, France, Pathology 
      Department, Vannes General Hospital, Vannes, Brest Occidental University, 
      Rheumatology Unit, Hopital de la Cavale Blanche, EA 2216, ESPRI 29, Brest 
      University, Brest, Rheumatology Department, Hotel Dieu University Hospital, 
      Nantes, Department of Internal Medicine, Nord-de-France University, Claude-Huriez 
      Hospital, Lille, Rheumatology Department, Rouen University Hospital, Rouen and 
      Brest Occidental University, Clinical Investigation Centre, Institut National de 
      la Sante et de la Recherche Medicale, Brest, France.
FAU - Lesourd, Agnes
AU  - Lesourd A
AD  - Pathology Department, Brest University Hospital, Brest, France, Pathology 
      Department, Vannes General Hospital, Vannes, Brest Occidental University, 
      Rheumatology Unit, Hopital de la Cavale Blanche, EA 2216, ESPRI 29, Brest 
      University, Brest, Rheumatology Department, Hotel Dieu University Hospital, 
      Nantes, Department of Internal Medicine, Nord-de-France University, Claude-Huriez 
      Hospital, Lille, Rheumatology Department, Rouen University Hospital, Rouen and 
      Brest Occidental University, Clinical Investigation Centre, Institut National de 
      la Sante et de la Recherche Medicale, Brest, France.
FAU - Jousse-Joulin, Sandrine
AU  - Jousse-Joulin S
AD  - Pathology Department, Brest University Hospital, Brest, France, Pathology 
      Department, Vannes General Hospital, Vannes, Brest Occidental University, 
      Rheumatology Unit, Hopital de la Cavale Blanche, EA 2216, ESPRI 29, Brest 
      University, Brest, Rheumatology Department, Hotel Dieu University Hospital, 
      Nantes, Department of Internal Medicine, Nord-de-France University, Claude-Huriez 
      Hospital, Lille, Rheumatology Department, Rouen University Hospital, Rouen and 
      Brest Occidental University, Clinical Investigation Centre, Institut National de 
      la Sante et de la Recherche Medicale, Brest, France Pathology Department, Brest 
      University Hospital, Brest, France, Pathology Department, Vannes General 
      Hospital, Vannes, Brest Occidental University, Rheumatology Unit, Hopital de la 
      Cavale Blanche, EA 2216, ESPRI 29, Brest University, Brest, Rheumatology 
      Department, Hotel Dieu University Hospital, Nantes, Department of Internal 
      Medicine, Nord-de-France University, Claude-Huriez Hospital, Lille, Rheumatology 
      Department, Rouen University Hospital, Rouen and Brest Occidental University, 
      Clinical Investigation Centre, Institut National de la Sante et de la Recherche 
      Medicale, Brest, France.
FAU - Berthelot, Jean-Marie
AU  - Berthelot JM
AD  - Pathology Department, Brest University Hospital, Brest, France, Pathology 
      Department, Vannes General Hospital, Vannes, Brest Occidental University, 
      Rheumatology Unit, Hopital de la Cavale Blanche, EA 2216, ESPRI 29, Brest 
      University, Brest, Rheumatology Department, Hotel Dieu University Hospital, 
      Nantes, Department of Internal Medicine, Nord-de-France University, Claude-Huriez 
      Hospital, Lille, Rheumatology Department, Rouen University Hospital, Rouen and 
      Brest Occidental University, Clinical Investigation Centre, Institut National de 
      la Sante et de la Recherche Medicale, Brest, France.
FAU - Hachulla, Eric
AU  - Hachulla E
AD  - Pathology Department, Brest University Hospital, Brest, France, Pathology 
      Department, Vannes General Hospital, Vannes, Brest Occidental University, 
      Rheumatology Unit, Hopital de la Cavale Blanche, EA 2216, ESPRI 29, Brest 
      University, Brest, Rheumatology Department, Hotel Dieu University Hospital, 
      Nantes, Department of Internal Medicine, Nord-de-France University, Claude-Huriez 
      Hospital, Lille, Rheumatology Department, Rouen University Hospital, Rouen and 
      Brest Occidental University, Clinical Investigation Centre, Institut National de 
      la Sante et de la Recherche Medicale, Brest, France.
FAU - Hatron, Pierre-Yves
AU  - Hatron PY
AD  - Pathology Department, Brest University Hospital, Brest, France, Pathology 
      Department, Vannes General Hospital, Vannes, Brest Occidental University, 
      Rheumatology Unit, Hopital de la Cavale Blanche, EA 2216, ESPRI 29, Brest 
      University, Brest, Rheumatology Department, Hotel Dieu University Hospital, 
      Nantes, Department of Internal Medicine, Nord-de-France University, Claude-Huriez 
      Hospital, Lille, Rheumatology Department, Rouen University Hospital, Rouen and 
      Brest Occidental University, Clinical Investigation Centre, Institut National de 
      la Sante et de la Recherche Medicale, Brest, France.
FAU - Goeb, Vincent
AU  - Goeb V
AD  - Pathology Department, Brest University Hospital, Brest, France, Pathology 
      Department, Vannes General Hospital, Vannes, Brest Occidental University, 
      Rheumatology Unit, Hopital de la Cavale Blanche, EA 2216, ESPRI 29, Brest 
      University, Brest, Rheumatology Department, Hotel Dieu University Hospital, 
      Nantes, Department of Internal Medicine, Nord-de-France University, Claude-Huriez 
      Hospital, Lille, Rheumatology Department, Rouen University Hospital, Rouen and 
      Brest Occidental University, Clinical Investigation Centre, Institut National de 
      la Sante et de la Recherche Medicale, Brest, France.
FAU - Vittecoq, Olivier
AU  - Vittecoq O
AD  - Pathology Department, Brest University Hospital, Brest, France, Pathology 
      Department, Vannes General Hospital, Vannes, Brest Occidental University, 
      Rheumatology Unit, Hopital de la Cavale Blanche, EA 2216, ESPRI 29, Brest 
      University, Brest, Rheumatology Department, Hotel Dieu University Hospital, 
      Nantes, Department of Internal Medicine, Nord-de-France University, Claude-Huriez 
      Hospital, Lille, Rheumatology Department, Rouen University Hospital, Rouen and 
      Brest Occidental University, Clinical Investigation Centre, Institut National de 
      la Sante et de la Recherche Medicale, Brest, France.
FAU - Pers, Jacques Olivier
AU  - Pers JO
AD  - Pathology Department, Brest University Hospital, Brest, France, Pathology 
      Department, Vannes General Hospital, Vannes, Brest Occidental University, 
      Rheumatology Unit, Hopital de la Cavale Blanche, EA 2216, ESPRI 29, Brest 
      University, Brest, Rheumatology Department, Hotel Dieu University Hospital, 
      Nantes, Department of Internal Medicine, Nord-de-France University, Claude-Huriez 
      Hospital, Lille, Rheumatology Department, Rouen University Hospital, Rouen and 
      Brest Occidental University, Clinical Investigation Centre, Institut National de 
      la Sante et de la Recherche Medicale, Brest, France.
FAU - Marcorelles, Pascale
AU  - Marcorelles P
AD  - Pathology Department, Brest University Hospital, Brest, France, Pathology 
      Department, Vannes General Hospital, Vannes, Brest Occidental University, 
      Rheumatology Unit, Hopital de la Cavale Blanche, EA 2216, ESPRI 29, Brest 
      University, Brest, Rheumatology Department, Hotel Dieu University Hospital, 
      Nantes, Department of Internal Medicine, Nord-de-France University, Claude-Huriez 
      Hospital, Lille, Rheumatology Department, Rouen University Hospital, Rouen and 
      Brest Occidental University, Clinical Investigation Centre, Institut National de 
      la Sante et de la Recherche Medicale, Brest, France.
FAU - Nowak, Emmanuel
AU  - Nowak E
AD  - Pathology Department, Brest University Hospital, Brest, France, Pathology 
      Department, Vannes General Hospital, Vannes, Brest Occidental University, 
      Rheumatology Unit, Hopital de la Cavale Blanche, EA 2216, ESPRI 29, Brest 
      University, Brest, Rheumatology Department, Hotel Dieu University Hospital, 
      Nantes, Department of Internal Medicine, Nord-de-France University, Claude-Huriez 
      Hospital, Lille, Rheumatology Department, Rouen University Hospital, Rouen and 
      Brest Occidental University, Clinical Investigation Centre, Institut National de 
      la Sante et de la Recherche Medicale, Brest, France.
FAU - Saraux, Alain
AU  - Saraux A
AD  - Pathology Department, Brest University Hospital, Brest, France, Pathology 
      Department, Vannes General Hospital, Vannes, Brest Occidental University, 
      Rheumatology Unit, Hopital de la Cavale Blanche, EA 2216, ESPRI 29, Brest 
      University, Brest, Rheumatology Department, Hotel Dieu University Hospital, 
      Nantes, Department of Internal Medicine, Nord-de-France University, Claude-Huriez 
      Hospital, Lille, Rheumatology Department, Rouen University Hospital, Rouen and 
      Brest Occidental University, Clinical Investigation Centre, Institut National de 
      la Sante et de la Recherche Medicale, Brest, France Pathology Department, Brest 
      University Hospital, Brest, France, Pathology Department, Vannes General 
      Hospital, Vannes, Brest Occidental University, Rheumatology Unit, Hopital de la 
      Cavale Blanche, EA 2216, ESPRI 29, Brest University, Brest, Rheumatology 
      Department, Hotel Dieu University Hospital, Nantes, Department of Internal 
      Medicine, Nord-de-France University, Claude-Huriez Hospital, Lille, Rheumatology 
      Department, Rouen University Hospital, Rouen and Brest Occidental University, 
      Clinical Investigation Centre, Institut National de la Sante et de la Recherche 
      Medicale, Brest, France.
FAU - Devauchelle-Pensec, Valerie
AU  - Devauchelle-Pensec V
AD  - Pathology Department, Brest University Hospital, Brest, France, Pathology 
      Department, Vannes General Hospital, Vannes, Brest Occidental University, 
      Rheumatology Unit, Hopital de la Cavale Blanche, EA 2216, ESPRI 29, Brest 
      University, Brest, Rheumatology Department, Hotel Dieu University Hospital, 
      Nantes, Department of Internal Medicine, Nord-de-France University, Claude-Huriez 
      Hospital, Lille, Rheumatology Department, Rouen University Hospital, Rouen and 
      Brest Occidental University, Clinical Investigation Centre, Institut National de 
      la Sante et de la Recherche Medicale, Brest, France Pathology Department, Brest 
      University Hospital, Brest, France, Pathology Department, Vannes General 
      Hospital, Vannes, Brest Occidental University, Rheumatology Unit, Hopital de la 
      Cavale Blanche, EA 2216, ESPRI 29, Brest University, Brest, Rheumatology 
      Department, Hotel Dieu University Hospital, Nantes, Department of Internal 
      Medicine, Nord-de-France University, Claude-Huriez Hospital, Lille, Rheumatology 
      Department, Rouen University Hospital, Rouen and Brest Occidental University, 
      Clinical Investigation Centre, Institut National de la Sante et de la Recherche 
      Medicale, Brest, France valerie.devauchelle-pensec@chu-brest.fr.
LA  - eng
PT  - Journal Article
PT  - Multicenter Study
DEP - 20141127
PL  - England
TA  - Rheumatology (Oxford)
JT  - Rheumatology (Oxford, England)
JID - 100883501
SB  - IM
MH  - Biopsy/statistics & numerical data
MH  - Humans
MH  - Observer Variation
MH  - Reproducibility of Results
MH  - Salivary Glands, Minor/*pathology
MH  - Sjogren's Syndrome/*pathology
OTO - NOTNLM
OT  - Chisholm
OT  - Sjogren's syndrome
OT  - focus score
OT  - minor salivary gland biopsy
OT  - reliability
EDAT- 2014/11/30 06:00
MHDA- 2015/07/29 06:00
CRDT- 2014/11/30 06:00
PHST- 2014/05/19 00:00 [received]
PHST- 2014/11/30 06:00 [entrez]
PHST- 2014/11/30 06:00 [pubmed]
PHST- 2015/07/29 06:00 [medline]
AID - keu453 [pii]
AID - 10.1093/rheumatology/keu453 [doi]
PST - ppublish
SO  - Rheumatology (Oxford). 2015 Jun;54(6):1056-64. doi: 10.1093/rheumatology/keu453. 
      Epub 2014 Nov 27.