PMID- 25434225
OWN - NLM
STAT- MEDLINE
DCOM- 20150403
LR  - 20161020
IS  - 0869-8139 (Print)
IS  - 0869-8139 (Linking)
VI  - 99
IP  - 10
DP  - 2013 Oct
TI  - [Brain-derived neurotrophic factor: the influence on the genetically and 
      epigenetically determined behavioral disorders].
PG  - 1125-37
AB  - Recent investigations have widened the knowledge concerning the brain derived 
      neurotrophic factor (BDNF). The review concentrates on the data of literature and 
      original data of authors on BDNF effects on genetically and epigenetically 
      defined behavioral disorders. Specifically it describes the implication of the 
      brain serotonergic system and the role of genotype in the neuroprotective effects 
      of BDNF. The review provides evidence that: 1) genes encoding key elements of the 
      brain serotonergic system (tryptophan hydroxylase-2, 5-HT1A and 5-HT2A receptors) 
      are implicated in the effect ofBDNF; 2) acute central administration of BDNF 
      produced long-term ameliorative effects on some animal models of genetically 
      defined behavior disorders; 3) BDNF decreased behavioral disorders induced by 
      prenatal stress and ethanol exposure and may play an important role in the 
      treatment of epigenetically defined pathological behavior.
FAU - Popova, N K
AU  - Popova NK
FAU - Morozova, M V
AU  - Morozova MV
LA  - rus
PT  - English Abstract
PT  - Journal Article
PT  - Review
PL  - Russia (Federation)
TA  - Ross Fiziol Zh Im I M Sechenova
JT  - Rossiiskii fiziologicheskii zhurnal imeni I.M. Sechenova
JID - 9715665
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Receptors, Serotonin)
SB  - IM
MH  - Animals
MH  - Brain-Derived Neurotrophic Factor/genetics/*metabolism/therapeutic use
MH  - *Epigenesis, Genetic
MH  - Fetal Alcohol Spectrum Disorders/drug therapy/genetics/metabolism
MH  - Humans
MH  - Mental Disorders/drug therapy/*genetics/metabolism
MH  - Receptors, Serotonin/genetics/metabolism
EDAT- 2013/10/01 00:00
MHDA- 2015/04/04 06:00
CRDT- 2014/12/02 06:00
PHST- 2014/12/02 06:00 [entrez]
PHST- 2013/10/01 00:00 [pubmed]
PHST- 2015/04/04 06:00 [medline]
PST - ppublish
SO  - Ross Fiziol Zh Im I M Sechenova. 2013 Oct;99(10):1125-37.