PMID- 25435396
OWN - NLM
STAT- MEDLINE
DCOM- 20150820
LR  - 20141222
IS  - 1791-2431 (Electronic)
IS  - 1021-335X (Linking)
VI  - 33
IP  - 2
DP  - 2015 Feb
TI  - MLLT10 and IL3 rearrangement together with a complex four-way translocation and 
      trisomy 4 in a patient with early T-cell precursor acute lymphoblastic leukemia: 
      A case report.
PG  - 625-30
LID - 10.3892/or.2014.3624 [doi]
AB  - Cytogenetic classification of acute lymphoblastic leukemia (ALL) is primarily 
      based on numerical and structural chromosomal abnormalities. In T-cell ALL 
      (T-ALL), chromosomal rearrangements are identified in up to 70% of the patients 
      while the remaining patients show a normal karyotype. In the present study, a 
      16-year-old male was diagnosed with T-precursor cell ALL and a normal karyotype 
      after standard GTG-banding, was studied retrospectively (>10 years after 
      diagnosis) in frame of a research project by molecular approaches. In addition to 
      molecular cytogenetics, multiplex ligation-dependent probe amplification (MLPA) 
      and high resolution array-comparative genomic hybridization (aCGH) were also 
      applied. Thus, the following yet unrecognized balanced chromosomal aberrations 
      were detected: der(3)t(3;5)(p23;q31.1), der(5)t(3;5)(p23;q35.3), 
      der(5)t(5;10)(q31.1;p12.3) and der(10)t(5;10)(q35.3;p12.3). The oncogene MLLT10 
      was involved in this rearrangement as was the IL3 gene; in addition, trisomy 4 
      was present. All of these clonal aberrations were found in 40% of the cells. Even 
      if this complex karyotype would have been identified at the time of diagnosis, 
      most likely no other protocol of anticancer therapy (ALL-BFM 95) would have been 
      applied. Three months after the end of a successful 2-year treatment, the patient 
      suffered from isolated bone marrow relapse and died of sepsis during ALL-REZ-BFM 
      protocol treatment.
FAU - Othman, Moneeb A K
AU  - Othman MA
AD  - Jena University Hospital, Friedrich Schiller University, Institute of Human 
      Genetics, Jena, Germany.
FAU - Melo, Joana B
AU  - Melo JB
AD  - Laboratory of Cytogenetics and Genomics, Faculty of Medicine, University of 
      Coimbra, Coimbra, Portugal.
FAU - Carreira, Isabel M
AU  - Carreira IM
AD  - Laboratory of Cytogenetics and Genomics, Faculty of Medicine, University of 
      Coimbra, Coimbra, Portugal.
FAU - Rincic, Martina
AU  - Rincic M
AD  - Jena University Hospital, Friedrich Schiller University, Institute of Human 
      Genetics, Jena, Germany.
FAU - Alhourani, Eyad
AU  - Alhourani E
AD  - Jena University Hospital, Friedrich Schiller University, Institute of Human 
      Genetics, Jena, Germany.
FAU - Wilhelm, Kathleen
AU  - Wilhelm K
AD  - Jena University Hospital, Friedrich Schiller University, Institute of Human 
      Genetics, Jena, Germany.
FAU - Gruhn, Bernd
AU  - Gruhn B
AD  - Department of Pediatrics (Oncology and Hematology), Jena University Hospital, 
      Friedrich Schiller University, Jena, Germany.
FAU - Glaser, Anita
AU  - Glaser A
AD  - Jena University Hospital, Friedrich Schiller University, Institute of Human 
      Genetics, Jena, Germany.
FAU - Liehr, Thomas
AU  - Liehr T
AD  - Jena University Hospital, Friedrich Schiller University, Institute of Human 
      Genetics, Jena, Germany.
LA  - eng
PT  - Case Reports
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20141125
PL  - Greece
TA  - Oncol Rep
JT  - Oncology reports
JID - 9422756
RN  - 0 (IL3 protein, human)
RN  - 0 (Interleukin-3)
RN  - 0 (MLLT10 protein, human)
RN  - 0 (Transcription Factors)
SB  - IM
MH  - Adolescent
MH  - Chromosomes, Human, Pair 4/*genetics
MH  - Cytogenetic Analysis/methods
MH  - Humans
MH  - Interleukin-3/*genetics
MH  - Male
MH  - Precursor T-Cell Lymphoblastic Leukemia-Lymphoma/*genetics
MH  - Prognosis
MH  - Retrospective Studies
MH  - Transcription Factors/*genetics
MH  - Translocation, Genetic
MH  - Trisomy/*genetics
EDAT- 2014/12/02 06:00
MHDA- 2015/08/21 06:00
CRDT- 2014/12/02 06:00
PHST- 2014/09/03 00:00 [received]
PHST- 2014/10/13 00:00 [accepted]
PHST- 2014/12/02 06:00 [entrez]
PHST- 2014/12/02 06:00 [pubmed]
PHST- 2015/08/21 06:00 [medline]
AID - 10.3892/or.2014.3624 [doi]
PST - ppublish
SO  - Oncol Rep. 2015 Feb;33(2):625-30. doi: 10.3892/or.2014.3624. Epub 2014 Nov 25.