PMID- 25435733
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20141201
LR  - 20200930
IS  - 0971-4502 (Print)
IS  - 0974-0449 (Electronic)
IS  - 0971-4502 (Linking)
VI  - 30
IP  - 4
DP  - 2014 Dec
TI  - Prevalence of Alloimmunization to Human Platelet Antigen Glycoproteins and Human 
      Leucocyte Antigen Class I in beta Thalassemia Major Patients in Western India.
PG  - 309-12
LID - 10.1007/s12288-013-0297-5 [doi]
AB  - Present management of beta thalassemia major by regular packed red blood cell (PRBC) 
      transfusions poses risk of alloimmunization not only to red blood cell antigens, 
      but also to human platelet antigens (HPA) and Human leucocyte antigens class I 
      (HLA I). However data in this context is very limited in Indian population. The 
      aim of the study was to determine the prevalence of alloimmunization to HPA and 
      HLA I in beta thalassemia major patients who have received multiple PRBC 
      transfusions over the years. A cross sectional study was performed at our 
      tertiary care blood bank. beta thalassemia major patients of more than 6 years of 
      age were included who were receiving fresh, leucoreduced and irradiated PRBC 
      units regularly with annual requirement of more than ten PRBC transfusions. A 
      total of 9 out of 80 (11.25 %) patients were found to be alloimmunized for HPA 
      antigens of various specificity and 24 out of 80 (30 %) developed antibodies to 
      HLA I. The awareness of development of alloimmunization to HPA and HLA antigens 
      in multi PRBC transfused thalassemics, despite use of leucofilters will prompt 
      us, to look for improvement in our current PRBC preparations to minimise platelet 
      alloimmunisation. Further studies are required to validate the findings and build 
      the base line data in this regard. This is of importance, especially in view of 
      providing suitable cross-matched platelets when required in future especially 
      when considering future haematopoietic stem cell transplantation (HSCT).
FAU - Philip, Joseph
AU  - Philip J
AD  - Department of Immunohematology and Blood Transfusion, Armed Forces Medical 
      College, Pune, India.
FAU - Kumar, Sudeep
AU  - Kumar S
AD  - Department of Immunohematology and Blood Transfusion, Armed Forces Medical 
      College, Pune, India.
FAU - Chatterjee, T
AU  - Chatterjee T
AD  - Department of Immunohematology and Blood Transfusion, Armed Forces Medical 
      College, Pune, India.
FAU - Mallhi, R S
AU  - Mallhi RS
AD  - Department of Immunohematology and Blood Transfusion, Armed Forces Medical 
      College, Pune, India.
LA  - eng
PT  - Journal Article
DEP - 20130828
PL  - India
TA  - Indian J Hematol Blood Transfus
JT  - Indian journal of hematology & blood transfusion : an official journal of Indian 
      Society of Hematology and Blood Transfusion
JID - 9425818
PMC - PMC4243396
OTO - NOTNLM
OT  - Anti-human leucocyte antigens
OT  - Anti-human platelet antigens
OT  - Haematopoietic stem cell transplantation
OT  - Packed red blood cell concentration
EDAT- 2014/12/02 06:00
MHDA- 2014/12/02 06:01
PMCR- 2015/12/01
CRDT- 2014/12/02 06:00
PHST- 2013/07/04 00:00 [received]
PHST- 2013/08/20 00:00 [accepted]
PHST- 2014/12/02 06:00 [entrez]
PHST- 2014/12/02 06:00 [pubmed]
PHST- 2014/12/02 06:01 [medline]
PHST- 2015/12/01 00:00 [pmc-release]
AID - 297 [pii]
AID - 10.1007/s12288-013-0297-5 [doi]
PST - ppublish
SO  - Indian J Hematol Blood Transfus. 2014 Dec;30(4):309-12. doi: 
      10.1007/s12288-013-0297-5. Epub 2013 Aug 28.