PMID- 25438747
OWN - NLM
STAT- MEDLINE
DCOM- 20150723
LR  - 20141202
IS  - 1973-8102 (Electronic)
IS  - 0010-9452 (Linking)
VI  - 60
DP  - 2014 Nov
TI  - Neural overlap between resting state and self-relevant activity in human 
      subcallosal cingulate cortex--single unit recording in an intracranial study.
PG  - 139-44
LID - S0010-9452(14)00299-8 [pii]
LID - 10.1016/j.cortex.2014.09.008 [doi]
AB  - High activity of the default mode network (DMN) has been proposed to be central 
      in processing self-relevant events. Thus far, this hypothesis of DMN function has 
      not been tested directly using neurophysiological techniques. To test for the 
      link between frontal midline DMN activity and self-relevant processing we 
      measured neuronal activity (single-neurons' firing rates) in human subcallosal 
      cingulate cortex (SCC) in the course of Deep Brain Stimulation surgery. We find 
      that firing rates in SCC did not change during the presentation of specifically 
      self-relevant stimuli when compared to the preceding pre-stimulus resting state 
      level. In contrast, we observed significant changes in firing rates during other 
      names in SCC. Such rest-self overlap seems to be specific for SCC since increase 
      in firing rates in response to self-relevant stimuli were observed in another 
      region, the subthalamic nucleus, in a group of Parkinson patients receiving deep 
      brain stimulation surgery. These results suggest specific relationship between 
      resting state and self-related activity, rest-self overlap, in specifically SCC 
      as core region of the default-mode network.
CI  - Copyright (c) 2014 Elsevier Ltd. All rights reserved.
FAU - Lipsman, Nir
AU  - Lipsman N
AD  - Division of Neurosurgery, Toronto Western Hospital, University of Toronto, 
      Canada.
FAU - Nakao, Takashi
AU  - Nakao T
AD  - Institute of Biomedical & Health Sciences, Hiroshima University, Japan.
FAU - Kanayama, Noriaki
AU  - Kanayama N
AD  - Graduate School of Arts and Sciences, Department of General Systems Studies, 
      University of Tokyo, Japan.
FAU - Krauss, Joachim K
AU  - Krauss JK
AD  - Department of Neurosurgery, Medizinische Hochschule, Hannover, Germany.
FAU - Anderson, Adam
AU  - Anderson A
AD  - Department of Psychology, University of Toronto, Canada.
FAU - Giacobbe, Peter
AU  - Giacobbe P
AD  - Division of Psychiatry, Toronto General Hospital, University of Toronto, Canada.
FAU - Hamani, Clement
AU  - Hamani C
AD  - Division of Neurosurgery, Toronto Western Hospital, University of Toronto, 
      Canada.
FAU - Hutchison, William D
AU  - Hutchison WD
AD  - Department of Physiology, University of Toronto, Canada.
FAU - Dostrovsky, Jonathan O
AU  - Dostrovsky JO
AD  - Department of Physiology, University of Toronto, Canada.
FAU - Womelsdorf, Thilo
AU  - Womelsdorf T
AD  - Department of Biology, York University, Canada.
FAU - Lozano, Andres M
AU  - Lozano AM
AD  - Division of Neurosurgery, Toronto Western Hospital, University of Toronto, 
      Canada.
FAU - Northoff, Georg
AU  - Northoff G
AD  - Department of Psychiatry, University of Ottawa Institute of Mental Health 
      Research, Canada; Taipei Medical University, Graduate Institute of Humanities in 
      Medicine, Taipei, Taiwan; Taipei Medical University-Shuang Ho Hospital, Brain and 
      Consciousness Research Center, New Taipei City, Taiwan; Centre for Cognition and 
      Brain Disorders (CBBD), Normal University Hangzhou, Hangzhou, China. Electronic 
      address: Georg.northoff@theroyal.ca.
LA  - eng
PT  - Journal Article
DEP - 20140928
PL  - Italy
TA  - Cortex
JT  - Cortex; a journal devoted to the study of the nervous system and behavior
JID - 0100725
SB  - IM
MH  - Deep Brain Stimulation
MH  - Depressive Disorder, Major/*physiopathology/therapy
MH  - Electroencephalography
MH  - Gyrus Cinguli/*physiology
MH  - Humans
MH  - Neurons/*physiology
MH  - Parkinson Disease/*physiopathology/therapy
MH  - Rest/*physiology
OTO - NOTNLM
OT  - Deep brain stimulation
OT  - Default-mode network
OT  - Resting state
OT  - Self-relevance
OT  - Single-unit recording
OT  - Subcallosal cingulate cortex
EDAT- 2014/12/03 06:00
MHDA- 2015/07/24 06:00
CRDT- 2014/12/03 06:00
PHST- 2013/05/02 00:00 [received]
PHST- 2013/12/04 00:00 [revised]
PHST- 2014/09/11 00:00 [accepted]
PHST- 2014/12/03 06:00 [entrez]
PHST- 2014/12/03 06:00 [pubmed]
PHST- 2015/07/24 06:00 [medline]
AID - S0010-9452(14)00299-8 [pii]
AID - 10.1016/j.cortex.2014.09.008 [doi]
PST - ppublish
SO  - Cortex. 2014 Nov;60:139-44. doi: 10.1016/j.cortex.2014.09.008. Epub 2014 Sep 28.