PMID- 25439047
OWN - NLM
STAT- MEDLINE
DCOM- 20150819
LR  - 20150511
IS  - 1537-2995 (Electronic)
IS  - 0041-1132 (Linking)
VI  - 55
IP  - 5
DP  - 2015 May
TI  - Comparison of plasma exchange procedures using three apheresis systems.
PG  - 1001-7
LID - 10.1111/trf.12948 [doi]
AB  - BACKGROUND: A new protocol for the Amicus separator (Fresenius Kabi) enables the 
      device to perform plasma exchange (PE). The aim of the study was to compare 
      retrospectively the plasma removal efficiency (PRE) of the Amicus, the Optia 
      (TerumoBCT), and the Spectra (TerumoBCT) when performing PEs. STUDY DESIGN AND 
      METHODS: We retrospectively reviewed patients who received at least one PE with 
      the Amicus and at least one PE with the Optia, the Spectra, or both. We collected 
      data regarding PRE, volume of anticoagulant and calcium-magnesium (Ca-Mg) 
      solution infused, and changes in laboratory data from patients' blood sampled 
      immediately before starting and immediately after finishing each PE procedure: 
      complete blood count, coagulation, acid-base equilibrium, and biochemistry 
      variables. We also collected severe adverse events (AEs). RESULTS: We performed 
      18, 44, and 14 PEs with the Amicus, Optia, and Spectra, respectively. We observed 
      significant differences among the Amicus, Optia, and Spectra regarding PRE 
      (79.8 +/- 8.2, 82.9 +/- 5.8, and 70.4 +/- 8.2%; p < 0.001), volume of anticoagulant 
      infused (542 +/- 196, 687 +/- 120, and 647 +/- 111 mL; p = 0.002), volume of Ca-Mg 
      solution infused (81 +/- 28, 56 +/- 16, and 63 +/- 15 mL; p < 0.001), absolute change 
      of ionic Ca (-0.04 +/- 0.13, -0.05 +/- 0.12, and -0.19 +/- 0.16 mmol/L; p = 0.002), and 
      absolute change of Na (1.18 +/- 1.97, 1.02 +/- 1.93, and 3.71 +/- 1.98 mEq/L; 
      p < 0.001). We observed no significant differences in other analytic variables 
      and we observed no severe AEs. CONCLUSION: The Amicus device could effectively 
      perform PE procedures. In terms of PRE, the Amicus and Optia were similar, but 
      both devices were superior to the Spectra. The Amicus used a lower volume of 
      anticoagulant when compared with the Optia.
CI  - (c) 2014 AABB.
FAU - Cid, Joan
AU  - Cid J
AD  - Apheresis Unit, Department of Hemotherapy and Hemostasis, CDB, IDIBAPS, Hospital 
      Clinic, Barcelona, Spain.
FAU - Molina, Juan M
AU  - Molina JM
AD  - Apheresis Unit, Department of Hemotherapy and Hemostasis, CDB, IDIBAPS, Hospital 
      Clinic, Barcelona, Spain.
FAU - Mustieles, Maria J
AU  - Mustieles MJ
AD  - Apheresis Unit, Department of Hemotherapy and Hemostasis, CDB, IDIBAPS, Hospital 
      Clinic, Barcelona, Spain.
FAU - Perianez, Montse
AU  - Perianez M
AD  - Apheresis Unit, Department of Hemotherapy and Hemostasis, CDB, IDIBAPS, Hospital 
      Clinic, Barcelona, Spain.
FAU - Lozano, Miguel
AU  - Lozano M
AD  - Apheresis Unit, Department of Hemotherapy and Hemostasis, CDB, IDIBAPS, Hospital 
      Clinic, Barcelona, Spain.
LA  - eng
PT  - Journal Article
DEP - 20141201
PL  - United States
TA  - Transfusion
JT  - Transfusion
JID - 0417360
SB  - IM
MH  - Adult
MH  - Aged
MH  - Blood Component Removal/*methods
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Plasma Exchange/*methods
MH  - Retrospective Studies
EDAT- 2014/12/03 06:00
MHDA- 2015/08/20 06:00
CRDT- 2014/12/03 06:00
PHST- 2014/08/04 00:00 [received]
PHST- 2014/09/23 00:00 [revised]
PHST- 2014/10/15 00:00 [accepted]
PHST- 2014/12/03 06:00 [entrez]
PHST- 2014/12/03 06:00 [pubmed]
PHST- 2015/08/20 06:00 [medline]
AID - 10.1111/trf.12948 [doi]
PST - ppublish
SO  - Transfusion. 2015 May;55(5):1001-7. doi: 10.1111/trf.12948. Epub 2014 Dec 1.