PMID- 25439650 OWN - NLM STAT- MEDLINE DCOM- 20150616 LR - 20220408 IS - 1873-2542 (Electronic) IS - 0378-1135 (Linking) VI - 175 IP - 1 DP - 2015 Jan 30 TI - Vaccination with a genotype 1 modified live vaccine against porcine reproductive and respiratory syndrome virus significantly reduces viremia, viral shedding and transmission of the virus in a quasi-natural experimental model. PG - 7-16 LID - S0378-1135(14)00519-7 [pii] LID - 10.1016/j.vetmic.2014.11.007 [doi] AB - The present study assessed the efficacy of vaccination against genotype 1 porcine reproductive and respiratory syndrome virus (PRRSV) in terms of reduction of the transmission. Ninety-eight 3-week-old piglets were divided in two groups: V (n=40) and NV (n=58) that were housed separately. V animals were vaccinated with a commercial genotype 1 PRRSV vaccine while NV were kept as controls. On day 35 post-vaccination, 14 NV pigs were separated and inoculated intranasally with 2 ml of a heterologous genotype 1 PRRSV isolate ("seeder" pigs, SP). The other V and NV animals were distributed in groups of 5 pigs each. Two days later, one SP was introduced into each pen to expose V and NV to PRRSV. Sentinel pigs were allocated in adjacent pens. Follow-up was of 21 days. All NV (30/30) became viremic after contact with SP while only 53% of V pigs were detected so (21/40, p<0.05). Vaccination shortened viremia (12.2+/-4 versus 3.7+/-3.4 days in NV and V pigs, respectively, p<0.01). The 50% survival time for becoming infected (Kaplan-Meier) for V was 21 days (CI95%=14.1-27.9) compared to 7 days (CI95%=5.2-8.7) for NV animals (p<0.01). These differences were reflected in the R value as well: 2.78 (CI95%=2.13-3.43) for NV and 0.53 (CI95%=0.19-0.76) for V pigs (p<0.05). All sentinel pigs (10/10) in pens adjacent to NV+SP pens got infected compared to 1/4 sentinel pigs allocated contiguous to a V+SP pen. These data show that vaccination of piglets significantly decrease parameters related to PRRSV transmission. CI - Copyright (c) 2014 Elsevier B.V. All rights reserved. FAU - Pileri, Emanuela AU - Pileri E AD - Departament de Sanitat i Anatomia Animals, Universitat Autonoma de Barcelona, 08193 Bellaterra, Cerdanyola del Valles, Spain; Center de Recerca en Sanitat Animal (CReSA), UAB-IRTA, Campus de la Universitat Autonoma de Barcelona, 08193 Bellaterra, Cerdanyola del Valles, Spain. Electronic address: emanuela.pileri@cresa.uab.cat. FAU - Gibert, Elisa AU - Gibert E AD - Center de Recerca en Sanitat Animal (CReSA), UAB-IRTA, Campus de la Universitat Autonoma de Barcelona, 08193 Bellaterra, Cerdanyola del Valles, Spain. Electronic address: elisa.gibert@cresa.uab.cat. FAU - Soldevila, Ferran AU - Soldevila F AD - Center de Recerca en Sanitat Animal (CReSA), UAB-IRTA, Campus de la Universitat Autonoma de Barcelona, 08193 Bellaterra, Cerdanyola del Valles, Spain. Electronic address: ferransolde@gmail.com. FAU - Garcia-Saenz, Ariadna AU - Garcia-Saenz A AD - Center de Recerca en Sanitat Animal (CReSA), UAB-IRTA, Campus de la Universitat Autonoma de Barcelona, 08193 Bellaterra, Cerdanyola del Valles, Spain. Electronic address: ariadna.garcia@cresa.uab.cat. FAU - Pujols, Joan AU - Pujols J AD - Center de Recerca en Sanitat Animal (CReSA), UAB-IRTA, Campus de la Universitat Autonoma de Barcelona, 08193 Bellaterra, Cerdanyola del Valles, Spain. Electronic address: joan.pujols@cresa.uab.cat. FAU - Diaz, Ivan AU - Diaz I AD - Center de Recerca en Sanitat Animal (CReSA), UAB-IRTA, Campus de la Universitat Autonoma de Barcelona, 08193 Bellaterra, Cerdanyola del Valles, Spain. Electronic address: ivan.diaz@cresa.uab.cat. FAU - Darwich, Laila AU - Darwich L AD - Departament de Sanitat i Anatomia Animals, Universitat Autonoma de Barcelona, 08193 Bellaterra, Cerdanyola del Valles, Spain; Center de Recerca en Sanitat Animal (CReSA), UAB-IRTA, Campus de la Universitat Autonoma de Barcelona, 08193 Bellaterra, Cerdanyola del Valles, Spain. Electronic address: laila.darwich@uab.cat. FAU - Casal, Jordi AU - Casal J AD - Departament de Sanitat i Anatomia Animals, Universitat Autonoma de Barcelona, 08193 Bellaterra, Cerdanyola del Valles, Spain; Center de Recerca en Sanitat Animal (CReSA), UAB-IRTA, Campus de la Universitat Autonoma de Barcelona, 08193 Bellaterra, Cerdanyola del Valles, Spain. Electronic address: jordi.casal@uab.cat. FAU - Martin, Marga AU - Martin M AD - Departament de Sanitat i Anatomia Animals, Universitat Autonoma de Barcelona, 08193 Bellaterra, Cerdanyola del Valles, Spain; Center de Recerca en Sanitat Animal (CReSA), UAB-IRTA, Campus de la Universitat Autonoma de Barcelona, 08193 Bellaterra, Cerdanyola del Valles, Spain. Electronic address: marga.martin@uab.cat. FAU - Mateu, Enric AU - Mateu E AD - Departament de Sanitat i Anatomia Animals, Universitat Autonoma de Barcelona, 08193 Bellaterra, Cerdanyola del Valles, Spain; Center de Recerca en Sanitat Animal (CReSA), UAB-IRTA, Campus de la Universitat Autonoma de Barcelona, 08193 Bellaterra, Cerdanyola del Valles, Spain. Electronic address: enrich.mateu@uab.cat. LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20141115 PL - Netherlands TA - Vet Microbiol JT - Veterinary microbiology JID - 7705469 RN - 0 (Antibodies, Viral) RN - 0 (Vaccines, Attenuated) RN - 0 (Viral Vaccines) SB - IM MH - Administration, Intranasal/veterinary MH - Animals MH - Antibodies, Viral/*immunology MH - Genotype MH - Models, Theoretical MH - Porcine Reproductive and Respiratory Syndrome/*immunology/transmission/virology MH - Porcine respiratory and reproductive syndrome virus/*immunology MH - Swine MH - Vaccination/*veterinary MH - Vaccines, Attenuated/immunology MH - Viral Vaccines/*immunology MH - Viremia/veterinary MH - Virus Shedding OTO - NOTNLM OT - Basic reproduction ratio OT - PRRS virus OT - Pig OT - Vaccine EDAT- 2014/12/03 06:00 MHDA- 2015/06/17 06:00 CRDT- 2014/12/03 06:00 PHST- 2014/07/22 00:00 [received] PHST- 2014/11/03 00:00 [revised] PHST- 2014/11/06 00:00 [accepted] PHST- 2014/12/03 06:00 [entrez] PHST- 2014/12/03 06:00 [pubmed] PHST- 2015/06/17 06:00 [medline] AID - S0378-1135(14)00519-7 [pii] AID - 10.1016/j.vetmic.2014.11.007 [doi] PST - ppublish SO - Vet Microbiol. 2015 Jan 30;175(1):7-16. doi: 10.1016/j.vetmic.2014.11.007. Epub 2014 Nov 15.